Access the full text.
Sign up today, get DeepDyve free for 14 days.
K. Günther, T. Brabletz, C. Kraus, O. Dworak, M. Reymond, A. Jung, W. Hohenberger, T. Kirchner, F. Köckerling, W. Ballhausen (1998)
Predictive value of nuclear betacatenin expression for the occurrence of distant metastases in rectal cancerDiseases of the Colon & Rectum, 41
S. Wong, E. Lo, K. Lee, J. Chan, W. Hsiao (2004)
Prognostic and Diagnostic Significance of β-Catenin Nuclear Immunostaining in Colorectal CancerClinical Cancer Research, 10
W. Tang, N. Kokudo, Y. Sugawara, Q. Guo, H. Imamura, K. Sano, Hirona Karako, Xian-Jun Qu, M. Nakata, M. Makuuchi (2005)
Des-gamma-carboxyprothrombin expression in cancer and/or non-cancer liver tissues: association with survival of patients with resectable hepatocellular carcinoma.Oncology reports, 13 1
W. Tang, K. Miki, N. Kokudo, Y. Sugawara, H. Imamura, M. Minagawa, Lian-Wen Yuan, S. Ohnishi, M. Makuuchi (2003)
Des-gamma-carboxy prothrombin in cancer and non-cancer liver tissue of patients with hepatocellular carcinoma.International journal of oncology, 22 5
Y. Li, A. Bharti., D. Chen, J. Gong, D. Kufe (1998)
Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin.Molecular and cellular biology, 18 12
M. Hollingsworth, B. Swanson (2004)
Mucins in cancer: protection and control of the cell surfaceNature Reviews Cancer, 4
Y. Wen, T. Caffrey, M. Wheelock, Keith Johnson, M. Hollingsworth (2003)
Nuclear association of the cytoplasmic tail of MUC1 and beta-catenin.The Journal of biological chemistry, 278 39
B. Turner (2019)
International Union Against Cancer (UICC)B-Model Gromov-Witten Theory
J. Schroeder, Melissa Adriance, Melissa Thompson, T. Camenisch, S. Gendler (2003)
MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasion.Oncogene, 22 9
E. Fernebro, P. Bendahl, M. Dictor, A. Persson, M. Fernö, M. Nilbert (2004)
Immunohistochemical patterns in rectal cancer: Application of tissue microarray with prognostic correlationsInternational Journal of Cancer, 111
Nobuoki Kohno, M. Akiyama, S. Kyoizumi, Masayuki Hakoda, K. Kobuke, M. Yamakido (1988)
Detection of soluble tumor-associated antigens in sera and effusions using novel monoclonal antibodies, KL-3 and KL-6, against lung adenocarcinoma.Japanese journal of clinical oncology, 18 3
(2005)
Oncogenic beta - catenin signaling networks in colorectal cancer
Y. Choi, Y. Shim, Sang-Hui Kim, Dae-Soon Son, Hye-Sook Lee, G. Kim, Joungho Han, Jhingook Kim (2003)
Prognostic significance of E-cadherin and beta-catenin in resected stage I non-small cell lung cancer.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 24 3
T. He, A. Sparks, C. Rago, H. Hermeking, L. Zawel, L. Costa, P. Morin, B. Vogelstein, K. Kinzler (1998)
Identification of c-MYC as a target of the APC pathway.Science, 281 5382
J. Behrens (2005)
The role of the Wnt signalling pathway in colorectal tumorigenesis.Biochemical Society transactions, 33 Pt 4
Lei Huang, Jian Ren, Dongshu Chen, Yongqing Li, S. Kharbanda, D. Kufe (2003)
MUC1 Cytoplasmic Domain Coactivates Wnt Target Gene Transcription and Confers TransformationCancer Biology & Therapy, 2
(2007)
cancer specific survival : A long - term follow - up study
M. Ozawa, H. Baribault, R. Kemler (1989)
The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.The EMBO Journal, 8
Q. Guo, Wei Tang, Y. Inagaki, Y. Midorikawa, N. Kokudo, Y. Sugawara, M. Nakata, T. Konishi, H. Nagawa, M. Makuuchi (2006)
Clinical significance of subcellular localization of KL-6 mucin in primary colorectal adenocarcinoma and metastatic tissues.World journal of gastroenterology, 12 1
大野 哲郎 (2007)
Prognostic significance of combined expression of MUC1 and adhesion molecules in advanced gastric cancer
S. Baldus, S. Mönig, Sandra Huxel, S. Landsberg, F. Hanisch, Katja Engelmann, P. Schneider, J. Thiele, A. Hölscher, H. Dienes (2004)
MUC1 and Nuclear β-Catenin Are Coexpressed at the Invasion Front of Colorectal Carcinomas and Are Both Correlated with Tumor PrognosisClinical Cancer Research, 10
(2001)
The importance of MUC 1 cellular localization in patients with breast carcinoma : an immunohistologic study of 71 patients and review of the literature
S. Han, H. Chun, C. Park, S. Kang, S. Kim, D. Sohn, S. Yun, W. Lee (2006)
Prognostic significance of beta-catenin in colorectal cancer with liver metastasis.Clinical oncology (Royal College of Radiologists (Great Britain)), 18 10
J. Byrd, R. Bresalier (2004)
Mucins and mucin binding proteins in colorectal cancerCancer and Metastasis Reviews, 23
T. Hörkkö, K. Klintrup, J. Mäkinen, Juha Näpänkangas, H. Tuominen, J. Mäkelä, T. Karttunen, M. Mäkinen (2006)
Budding invasive margin and prognosis in colorectal cancer--no direct association with beta-catenin expression.European journal of cancer, 42 7
Lei Huang, Dongshu Chen, Derek Liu, L. Yin, S. Kharbanda, D. Kufe (2005)
MUC1 oncoprotein blocks glycogen synthase kinase 3beta-mediated phosphorylation and degradation of beta-catenin.Cancer research, 65 22
Q. Guo, Wei Tang, Y. Inagaki, N. Kokudo, Y. Sugawara, Hirona Karako, M. Nakata, M. Makuuchi (2007)
Subcellular localization of KL-6 mucin in colorectal carcinoma cell lines: association with metastatic potential and cell morphology.Oncology reports, 17 5
K. Maruyama, A. Ochiai, S. Akimoto, Satoshi Nakamura, S. Baba, Y. Moriya, S. Hirohashi (2000)
Cytoplasmic Beta-Catenin Accumulation as a Predictor of Hematogenous Metastasis in Human Colorectal CancerOncology, 59
J. Potter (1999)
Colorectal cancer: molecules and populations.Journal of the National Cancer Institute, 91 11
Yi Cao, P. Schlag, U. Karsten (1997)
Immunodetection of epithelial mucin (MUC1, MUC3) and mucin-associated glycotopes (TF, Tn, and sialosyl-Tn) in benign and malignant lesions of colonic epithelium: apolar localization corresponds to malignant transformationVirchows Archiv, 431
O. Tetsu, F. McCormick (1999)
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.Nature, 398 6726
Interaction of MUC1 with β-catenin plays a significant role in tumor progression and invasion. However, the clinical significance of coexpression of MUC1 and subcellular β-catenin expression in colorectal carcinoma remains unclear. The present study evaluated the clinicopathological significance of their combined expression for predicting prognosis. Seventy-seven colorectal carcinomas were subjected to immunohistochemical staining with anti-MUC1 KL-6 mucin and anti-β-catenin monoclonal antibody. Positive KL-6 mucin expression was correlated with decreased membranous β-catenin expression (P=0.022), while no correlation was found between positive KL-6 expression and nuclear β-catenin expression (P=0.142). Preservation of membranous β-catenin expression was detected in 35 cases (45.5%) and decreased membranous β-catenin expression was found in 42 cases (54.5%). Negative KL-6 expression was detected in 31 cases (41.3%) and positive expression was seen in 46 cases (59.7%). Combined positive KL-6 expression and decreased membranous β-catenin expression was found in 30 patients (39.0%), whose survival was significantly worse than that of patients with other expression patterns for these two molecules (53.3 vs. 84.4%, P=0.005). Multivariate analysis showed that this combination was as an independent predictor of survival. We concluded that the combined pattern of positive KL-6 expression and decreased membranous β-catenin expression by colorectal carcinoma is a useful biomarker for distinguishing a subgroup of patients with a worse prognosis.
Oncology Reports – Spandidos Publications
Published: Nov 1, 2008
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.