Access the full text.
Sign up today, get DeepDyve free for 14 days.
Se Jang, Jean-Charles Soria, Luo Wang, Khaled Hassan, R. Morice, Garrett Walsh, W. Hong, L. Mao (2001)
Activation of melanoma antigen tumor antigens occurs early in lung carcinogenesis.Cancer research, 61 21
Y. Kim, Seung Lee, S. Sung, Joo Kim (2005)
Can aberrant promoter hypermethylation of CpG islands predict the clinical outcome of non-small cell lung cancer after curative resection?The Annals of thoracic surgery, 79 4
D. Atanackovic, N. Altorki, Yanran Cao, E. Ritter, C. Ferrara, G. Ritter, E. Hoffman, C. Bokemeyer, L. Old, S. Gnjatic (2008)
Booster vaccination of cancer patients with MAGE-A3 protein reveals long-term immunological memory or tolerance depending on primingProceedings of the National Academy of Sciences, 105
E. Plaen, C. Traversari, J. Gaforio, J. Szikora, C. Smet, F. Brasseur, P. Bruggen, B. Lethé, C. Lurquin, P. Chomez, O. Backer, T. Boon, K. Arden, W. Cavenee, R. Brasseur (2005)
Structure, chromosomal localization, and expression of 12 genes of the MAGE familyImmunogenetics, 40
S. Jheon, D. Hyun, Sang-Chae Lee, G. Yoon, C. Jeon, Jong-Wook Park, C. Park, Man-Hong Jung, K. Lee, H. Chang (2004)
Lung cancer detection by a RT-nested PCR using MAGE A1--6 common primers.Lung cancer, 43 1
T. Tsuji, N. Altorki, G. Ritter, L. Old, S. Gnjatic (2009)
Characterization of Preexisting MAGE-A3-Specific CD4+ T Cells in Cancer Patients and Healthy Individuals and Their Activation by Protein Vaccination1The Journal of Immunology, 183
P. vanderBruggen, C. Traversari, P. Chomez, C. Lurquin, E. DePlaen, Van Bj, A. Knuth, T. Boon (1991)
A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma.Science, 254 5038
W. Zheng, W. Blot, M. Liao, Z. Wang, L. Levin, J. Zhao, J. Fraumeni, Y. Gao (1987)
Lung cancer and prior tuberculosis infection in Shanghai.British Journal of Cancer, 56
(2009)
J Immunol
A. Risch, C. Plass (2008)
Lung cancer epigenetics and geneticsInternational Journal of Cancer, 123
Pastorino (2010)
Lung cancer screeningBr J Cancer, 102
(2004)
detection by a RT - nested PCR using MAGE A 1 - 6 common primers
P. Anglim, T. Alonzo, I. Laird-Offringa (2008)
DNA methylation-based biomarkers for early detection of non-small cell lung cancer: an updateMolecular Cancer, 7
Dong-Sun Kim, S. Cha, Jae-Hee Lee, Yu-mi Lee, J. Choi, Min-Jin Kim, J. Lim, E. Lee, Chang-Ho Kim, T. Park, T. Jung, J. Park (2007)
Aberrant DNA methylation profiles of non-small cell lung cancers in a Korean population.Lung cancer, 58 1
Won Song, Youn Lee, Dan Lee, Jae Kim, Seung Lee, J. Nam, Sungwoo Park (2023)
MP44-04 IMPORTANCE OF THE ULTRASOUND CHARACTERISTICS OF REGIONS OF INTEREST BY MRI AND THE ADDITIONAL TARGET BIOPSY AROUND THEIR PERI-HYPOECHOIC LESIONS IN MR/TRUS SOFTWARE FUSION BIOPSY TO IMPROVE DETECTION RATE OF PROSTATE CANCERThe Journal of Urology, 209
(1968)
Early diagnosis of lung cancer.British Medical Journal, 2
P. Ulivi, W. Zoli, D. Calistri, F. Fabbri, A. Tesei, M. Rosetti, M. Mengozzi, D. Amadori (2006)
p16INK4A and CDH13 hypermethylation in tumor and serum of non‐small cell lung cancer patientsJournal of Cellular Physiology, 206
Bing Yang*, S. O’Herrin, Jianqiang Wu, Shannon Reagan-Shaw, Yongsheng Ma, Kumar Bhat, C. Gravekamp, V. Setaluri, N. Peters, F. Hoffmann, Hongzhuang Peng, A. Ivanov, A. Simpson, B. Longley (2007)
MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines.Cancer research, 67 20
(2003)
Methylation of p 16 INK 4 a in Chinese lung cancer patients : biological and clinical implications
T. Kurasawa (1998)
[The coexistence of pulmonary tuberculosis and lung cancer].Nihon rinsho. Japanese journal of clinical medicine, 56 12
H. Hsu, T.-P. Chen, Chiaokai Wen, Chein-Hui Hung, C-Y Chen, Jt Chen, Y.-C. Wang (2007)
Multiple genetic and epigenetic biomarkers for lung cancer detection in cytologically negative sputum and a nested case–control study for risk assessmentThe Journal of Pathology, 213
Hana Kim, Sang Kim, Sun-Hwa Lee, Hye Seong, Kyung-Ok Lee, C. Jeon, Yoo Hong, Sang Lee, T. Kim (2010)
Usefulness of melanoma antigen (MAGE) gene analysis in tissue samples from percutaneous needle aspiration biopsy of suspected lung cancer lesions.Lung cancer, 69 3
I. Mecklenburg, D. Stratakis, R. Huber, K. Häussinger, A. Morresi‐Hauf, G. Riethmüller, P. Kufer (2004)
Detection of melanoma antigen-A expression in sputum and bronchial lavage fluid of patients with lung cancer.Chest, 125 5 Suppl
J. Mulshine, Daniel Sullivan (2005)
Clinical practice. Lung cancer screening.The New England journal of medicine, 352 26
Jong Park, T. Kwon, I. Kim, S. Sohn, You Kim, C. Kim, O. Bae, Kyung-Seop Lee, Kang Lee, Cheong Lee, H. Chang, B. Choe, S. Ahn, C. Jeon (2002)
A new strategy for the diagnosis of MAGE-expressing cancers.Journal of immunological methods, 266 1-2
W. Sienel, C. Varwerk, A. Linder, D. Kaiser, M. Teschner, M. Delire, G. Stamatis, Bernward Passlick (2004)
Melanoma associated antigen (MAGE)-A3 expression in Stages I and II non-small cell lung cancer: results of a multi-center study.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 25 1
(2007)
in a Korean population
K. Olaussen, J. Soria, Y. Park, H. Kim, S. Kim, J. Ro, F. André, S. Jang (2005)
Assessing abnormal gene promoter methylation in paraffin-embedded sputum from patients with NSCLC.European journal of cancer, 41 14
C. Jeon, I. Shin, Jae-bok Park, Hyundong Chae (2010)
Prognostic Significance of MAGE in Peritoneal Washes in Gastric Carcinoma Patients Without Peritoneal Metastasis: Results of a 5-year Follow-up StudyJournal of Clinical Gastroenterology, 44
A. Chaturvedi, C. Gaydos, P. Agreda, Jeffrey Holden, N. Chatterjee, J. Goedert, N. Caporaso, E. Engels (2004)
Chlamydia pneumoniae Infection and Risk for Lung CancerCancer Epidemiology, Biomarkers & Prevention, 19
Yong Liu, Q. An, Ling Li, De-chao Zhang, Jinfeng Huang, Xiaoli Feng, S. Cheng, Yan-ning Gao (2003)
Hypermethylation of p16INK4a in Chinese lung cancer patients: biological and clinical implications.Carcinogenesis, 24 12
Yasufuku (2010)
Early diagnosis of lung cancerClin Chest Med, 31
The melanoma antigen gene (MAGE) A1-A6 RT-PCR system was developed for the detection of lung cancer cells in the sputum. However, we identified MAGE expression in some patients with non-malignant lung diseases. To understand these patterns of MAGE expression, we performed MAGE A3 methylation-specific PCR (MSP) and p16 MSP. We collected 24 biopsy specimens of lung cancer tissue and performed MAGE A1-A6 RT-PCR, MAGE A3 MSP and p16 MSP. RNA and DNA were simultaneously extracted from induced sputum specimens of 133 patients with lung diseases and 30 random sputum specimens of healthy individuals and the 3 molecular analyses were performed. The patients were diagnosed as 65 cases of lung cancer and 68 of benign lung diseases. Positive rates of MAGE A1-A6 RT-PCR, MAGE A3 MSP and p16 MSP were as follows: in lung cancer tissue, 87.5, 58.3 and 70.8%; in the sputum of lung cancer patients, 50.8, 46.2 and 63.1%; benign lung diseases, 10.3, 30.9 and 39.7%; and healthy individuals, 3.3, 6.7 and 3.3%. Of the 40 MAGE-positive cases, 33 were diagnosed with lung cancer and 7 as having benign lung diseases. From the 7 cases of MAGE-positive benign lung diseases, 6 cases showed methylation abnormalities. The MAGE-positive group revealed significantly higher rates of methylation abnormalities. Of the 40 MAGE-positive cases, 39 cases were found to be lung cancer or benign lung diseases with abnormal methylation. Thus, MAGE expression in the sputum suggests the presence of lung cancer cells or pre-cancerous cells.
Oncology Reports – Spandidos Publications
Published: Apr 1, 2012
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.