Access the full text.
Sign up today, get DeepDyve free for 14 days.
Yong Wang, Zhi Lu, Ningnin Wang, Jianzhou Feng, Junjie Zhang, L. Luan, Wei Zhao, Xiandong Zeng (2018)
Long noncoding RNA DANCR promotes colorectal cancer proliferation and metastasis via miR-577 spongingExperimental & Molecular Medicine, 50
Ting Zhan, Xiaoli Chen, X. Tian, Zheng Han, Meng Liu, Yanli Zou, Shasha Huang, Aifang Chen, Xueting Cheng, Junsheng Deng, Jie-xiong Tan, Xiaodong Huang (2020)
MiR-331-3p Links to Drug Resistance of Pancreatic Cancer Cells by Activating WNT/β-Catenin Signal via ST7LTechnology in Cancer Research & Treatment, 19
Shi-jiang Deng, Hengyu Chen, Zeng Ye, Shi-chang Deng, Shuai Zhu, Zhu Zeng, Chi He, Ming-liang Liu, Kang Huang, Jian-xin Zhong, Feng-yu Xu, Qiang Li, Yang Liu, Chun-you Wang, Gang Zhao (2018)
Hypoxia-induced LncRNA-BX111 promotes metastasis and progression of pancreatic cancer through regulating ZEB1 transcriptionOncogene, 37
Simin Li, Xiangqiong Liu, Hanluo Li, Hongying Pan, Aneesha Acharya, Y. Deng, Yang Yu, R. Haak, Jana Schmidt, G. Schmalz, D. Ziebolz (2018)
Integrated analysis of long noncoding RNA‐associated competing endogenous RNA network in periodontitisJournal of Periodontal Research, 53
Subash Gupta, Y. Tripathi (2017)
Potential of long non-coding RNAs in cancer patients: From biomarkers to therapeutic targetsInternational Journal of Cancer, 140
Guo-zheng Liu, Z. Jiang, Ming-yin Qiao, Fengyong Wang (2019)
Lnc‐GIHCG promotes cell proliferation and migration in gastric cancer through miR‐ 1281 adsorptionMolecular Genetics & Genomic Medicine, 7
Junhao Li, Shun Liu, Hui Zhou, L. Qu, Jianhua Yang (2013)
starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq dataNucleic Acids Research, 42
Longkun Liu, Yuhua Zhan, Yinwen Huang, Luyao Huang (2020)
LncRNA FGD5-AS1 can be predicted as therapeutic target in oral cancer.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
H. Sung, J. Ferlay, R. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, F. Bray (2021)
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 CountriesCA: A Cancer Journal for Clinicians, 71
Yafeng Fan, Hongxia Li, Zhongping Yu, W. Dong, Xiaoyan Cui, Jin-Hui Ma, Shengwen Li (2020)
Long non-coding RNA FGD5-AS1 promotes non-small cell lung cancer cell proliferation through sponging hsa-miR-107 to up-regulate FGFRL1Bioscience Reports, 40
Mary Zimmerman, Xiaoling Hu, Kebin Liu (2010)
Experimental metastasis and CTL adoptive transfer immunotherapy mouse model.Journal of visualized experiments : JoVE, 45
J. Périnel, M. Adham (2019)
Palliative therapy in pancreatic cancer-palliative surgery.Translational gastroenterology and hepatology, 4
Kaiwen Kong, Meng Guo, Yanfang Liu, Jian-ming Zheng (2020)
Progress in Animal Models of Pancreatic Ductal AdenocarcinomaJournal of Cancer, 11
Runjia Fu, Xiao-hong Wang, Ying Hu, H. Du, B. Dong, Sheng Ao, Li Zhang, Zhijian Sun, Lianhai Zhang, Guoqing Lv, J. Ji (2019)
Solamargine inhibits gastric cancer progression by regulating the expression of lncNEAT1_2 via the MAPK signaling pathwayInternational Journal of Oncology, 54
Lishui Shen, X. Hu, Ting Chen, Guilin Shen, D. Cheng (2019)
Integrated network analysis to explore the key mRNAs and lncRNAs in acute myocardial infarction.Mathematical biosciences and engineering : MBE, 16 6
Jinghui Yang, Xianling Cong, M. Ren, Hongyan Sun, Tao Liu, Gaoyang Chen, Qingyu Wang, Zhaoyan Li, Shan Yu, Qiwei Yang (2019)
Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal AdenocarcinomaJournal of Oncology, 2019
Jiaming Fan, Q. Wei, J. Liao, Y. Zou, D. Song, Dong-mei Xiong, Chao Ma, Xue Hu, X. Qu, Liqun Chen, Li Li, Yichun Yu, Xinyi Yu, Zhicai Zhang, Chen Zhao, Z. Zeng, Ruyi Zhang, Shujuan Yan, Tingting Wu, Xing-ye Wu, Y. Shu, J. Lei, Yasha Li, Wenwen Zhang, R. Haydon, H. Luu, A. Huang, T. He, Hua Tang (2017)
Noncanonical Wnt signaling plays an important role in modulating canonical Wnt-regulated stemness, proliferation and terminal differentiation of hepatic progenitorsOncotarget, 8
H. Nagano, Y. Tomimaru, H. Eguchi, N. Hama, H. Wada, K. Kawamoto, Shogo Kobayashi, M. Mori, Y. Doki (2013)
MicroRNA-29a induces resistance to gemcitabine through the Wnt/β-catenin signaling pathway in pancreatic cancer cells.International journal of oncology, 43 4
S. Modi, Devika Kir, Sulagna Banerjee, A. Saluja (2016)
Control of Apoptosis in Treatment and Biology of Pancreatic CancerJournal of Cellular Biochemistry, 117
Cefan Zhou, Changhua Yi, Yongxiang Yi, Wenying Qin, Yanan Yan, Xueying Dong, Xuewen Zhang, Yuan Huang, Rui Zhang, Jie Wei, D. Ali, M. Michalak, Xing-Zhen Chen, Jingfeng Tang (2020)
LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axesMolecular Cancer, 19
Lin Zhou, Xin Liang, Lingling Zhang, Liyan Yang, N. Nagao, Hongkun Wu, Chang Liu, Shengchao Lin, G. Cai, Jianwen Liu (2016)
MiR-27a-3p functions as an oncogene in gastric cancer by targeting BTG2Oncotarget, 7
Wei-guang Zhang, Chen Shen, Chenguang Li, Guang Yang, Huailei Liu, Xin Chen, Dan Zhu, Huichao Zou, Y. Zhen, Daming Zhang, Shiguang Zhao (2016)
miR‐577 inhibits glioblastoma tumor growth via the Wnt signaling pathwayMolecular Carcinogenesis, 55
W. Hilgers, C. Rosty, S. Hahn (2002)
Molecular pathogenesis of pancreatic cancer.Hematology/oncology clinics of North America, 16 1
F. Kümmerle, K. Rückert (1984)
Surgical treatment of pancreatic cancerWorld Journal of Surgery, 8
C. Yin, Qingjie Mou, Xinting Pan, Guoxin Zhang, Hongli Li, Yunbo Sun (2018)
MiR‐577 suppresses epithelial‐mesenchymal transition and metastasis of breast cancer by targeting Rab25Thoracic Cancer, 9
(2020)
Irreversible elec‐ troporation for liver metastasis from pancreatic cancer: A case report
Y. Lei, Yunfei Shi, Jin Duan, Yinqiang Liu, Guoli Lv, Rou Shi, Fujun Zhang, Qingmei Yang, Wei Zhao (2019)
Identification of alternative splicing and lncRNA genes in pathogenesis of small cell lung cancer based on their RNA sequencing.Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Ding Li, Xiaohui Jiang, Xueliang Zhang, Guangxin Cao, Ding Wang, Zhong Chen (2019)
Long noncoding RNA FGD5-AS1 promotes colorectal cancer cell proliferation, migration, and invasion through upregulating CDCA7 via sponging miR-302eIn Vitro Cellular & Developmental Biology - Animal, 55
(2017)
The involvement of lncRNAs in the devel‐ opment and progression of pancreatic cancer
Yeuan Lee, Y. Tan, C. Oon (2018)
Molecular targeted therapy: Treating cancer with specificityEuropean Journal of Pharmacology, 834
J. Neoptolemos (2011)
Adjuvant treatment of pancreatic cancer.European journal of cancer, 47 Suppl 3
Zhiqiang Fu, Changhao Chen, Quanbo Zhou, Yinxue Wang, Yue Zhao, Xiaohui Zhao, Wenzhu Li, Shangyou Zheng, Huilin Ye, Lin Wang, Zhanghai He, Qing Lin, Zhihua Li, Rufu Chen (2017)
LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9.Cancer letters, 410
(2016)
inhibits glioblastoma tumor growth via the Wnt signaling pathway
Zhe Jiang, Chunshan Jiang, Jinnv Fang (2018)
Up-regulated lnc-SNHG1 contributes to osteosarcoma progression through sequestration of miR-577 and activation of WNT2B/Wnt/β-catenin pathway.Biochemical and biophysical research communications, 495 1
Fu-rao Liu, Zebin Xia, Meichao Zhang, Jiping Ding, Yawen Feng, Jianwei Wu, Yun Dong, Wei Gao, Zengwei Han, Yuanhua Liu, Yuan Yao, Dong Li (2019)
SMARCAD1 Promotes Pancreatic Cancer Cell Growth and Metastasis through Wnt/β-catenin-Mediated EMTInternational Journal of Biological Sciences, 15
Michael Hamilton, T. Girke, E. Martinez (2018)
Global isoform-specific transcript alterations and deregulated networks in clear cell renal cell carcinomaOncotarget, 9
K. Livak, Thomas Schmittgen (2001)
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.Methods, 25 4
C. Du, Wang Hx, Ping Chen, Chen Ch (2019)
STAT3-induced upregulation of lncRNA DUXAP8 functions as ceRNA for miR-577 to promote the migration and invasion in colorectal cancer through the regulation of RAB14.European review for medical and pharmacological sciences, 23 14
Liyan Wang, Bin Li, Huanyv Jiang, L. Zhuang, Yong Liu (2015)
Inhibition effect of miR-577 on hepatocellular carcinoma cell growth via targeting β-catenin.Asian Pacific journal of tropical medicine, 8 11
MiR ‐ 27 a ‐ 3 p functions as an oncogene in gastric cancer by targeting BTG 2
Hehuan Zhu, Jun Lu, Hu Zhao, Zhan Chen, Qiang Cui, Zhiwen Lin, Xuyang Wang, Jie Wang, Hui-yue Dong, Shuiliang Wang, Jian-ming Tan (2018)
Functional Long Noncoding RNAs (lncRNAs) in Clear Cell Kidney Carcinoma Revealed by Reconstruction and Comprehensive Analysis of the lncRNA–miRNA–mRNA Regulatory NetworkMedical Science Monitor : International Medical Journal of Experimental and Clinical Research, 24
Lei Zhang, Hailing Cheng, Yuxia Yue, Shuangzhan Li, Daping Zhang, R. He (2018)
H19 knockdown suppresses proliferation and induces apoptosis by regulating miR-148b/WNT/β-catenin in ox-LDL -stimulated vascular smooth muscle cellsJournal of Biomedical Science, 25
Ying Li, Xiaojuan Yang, Xiaoning Kang, Shanglong Liu (2019)
The regulatory roles of long noncoding RNAs in the biological behavior of pancreatic cancerSaudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association, 25
Xiang-hua Liu, Ming Sun, Feng-qi Nie, Y. Ge, E. Zhang, D. Yin, R. Kong, Rui Xia, K. Lu, Jin-hai Li, W. De, Ke-ming Wang, Zhaoxia Wang (2014)
Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancerMolecular Cancer, 13
Joseph Evans, F. Feng, A. Chinnaiyan (2016)
The bright side of dark matter: lncRNAs in cancer.The Journal of clinical investigation, 126 8
L. Gordis, E. Gold (1984)
Epidemiology of pancreatic cancerWorld Journal of Surgery, 8
The objective of the present study was to clarify the expression characteristics of long non‑coding RNA (lncRNA) FGD5 antisense RNA 1 (FGD5‑AS1) in pancreatic cancer, as well as its biological function and underlying mechanism. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was utilized for the detection of FGD5‑AS1 and microRNA (miR)‑577 expression levels in pancreatic cancer tissues. Transfection was performed to upregulate or downregulate FGD5‑AS1 in pancreatic cancer cell lines. MTT and Transwell assays were then utilized to detect the proliferation, migration and invasion of cancer cells, respectively. Subsequently, dual‑luciferase reporter gene assay, RNA immunoprecipitation assay, RNA pull‑down assay, RT‑qPCR, western blotting, and Pearson's correlation analysis were employed to confirm the regulatory relationships among FGD5‑AS1, miR‑577, low‑density lipoprotein receptor‑related protein 6 (LRP6) and β‑catenin. Western blotting was employed to determine the expression levels of Axin2, cyclin D1 and c‑Myc. The expression level of FGD5‑AS1 was upregulated in pancreatic cancer tissues and cell lines. FGD5‑AS1 knockdown inhibited pancreatic cancer cell proliferation, migration and invasion. By contrast, miR‑577 was significantly inhibited in pancreatic cancer cells and tissues; its downregulation promoted pancreatic cancer cell proliferation, migration and invasion, and reversed the effects of FGD5‑AS1 knockdown on pancreatic cancer cells. In addition, it was revealed that miR‑577 was a target of FGD5‑AS1, and FGD5‑AS1 could modulate the expression levels of LRP6, β‑catenin, Axin2, cyclin D1 and c‑Myc via suppressing miR‑577. In conclusion, in pancreatic cancer, highly expressed FGD5‑AS1 activated the Wnt/β‑catenin signaling and promoted cancer cell proliferation, migration and invasion via suppression of miR‑577.
Oncology Reports – Spandidos Publications
Published: Jan 29, 2022
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.