Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/spandidos-publications/expression-profile-of-class-i-histone-deacetylases-in-human-cancer-zNCG00Vjhc
References
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
- Publisher
- Spandidos Publications
- Copyright
- Copyright © Spandidos Publications
- ISSN
- 1021-335X
- eISSN
- 1791-2431
- DOI
- 10.3892/or.18.4.769
- Publisher site
- See Article on Publisher Site
Abstract
Histone deacetylase (HDAC) activity is one of the widely used and well-established mechanisms for regulation of various genes in cancer. To identify which subtype of class I HDACs are overexpressed in cancers, we analyzed the expression of class I HDAC isotypes composed of HDAC1, 2, 3 and 8 in several cell lines and human cancer tissues, including cancer of the stomach, esophagus, colon, prostate, breast, ovary, lung, pancreas and thyroid. The results showed that >75% of human cancer tissues and their corresponding non-cancerous epithelium showed high expression of these class I HDACs. However, the immunoreactivity of HDAC8 in both prostatic cancer tissue and non-cancerous prostate glands was lower than that in other cancer tissues. Furthermore, 5-40% of cancer tissues overexpressed class I HDACs, when compared with normal epithelium. The results suggest the potential usefulness of HDAC inhibitors for the treatment of a wide variety of human cancers.
Journal
Oncology Reports – Spandidos Publications
Published: Oct 1, 2007