Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/spandidos-publications/expression-and-phosphorylation-of-stathmin-correlate-with-cell-CFVJKzXtXx
References (44)
-
B. Belletti, M. Nicoloso, M. Schiappacassi, Stefania Berton, F. Lovat, Katarina Wolf, V. Canzonieri, S. D'Andrea, A. Zucchetto, P. Friedl, A. Colombatti, G. Baldassarre (2008)
Stathmin activity influences sarcoma cell shape, motility, and metastatic potential.Molecular biology of the cell, 19 5
-
Phedra Amayed, D. Pantaloni, M. Carlier (2002)
The Effect of Stathmin Phosphorylation on Microtubule Assembly Depends on Tubulin Critical Concentration* 210The Journal of Biological Chemistry, 277
-
Philipp Niethammer, P. Bastiaens, E. Karsenti (2004)
Stathmin-Tubulin Interaction Gradients in Motile and Mitotic CellsScience, 303
-
P. Sadow, K. Rumilla, L. Erickson, R. Lloyd (2008)
Stathmin Expression in Pheochromocytomas, Paragangliomas, and in other Endocrine TumorsEndocrine Pathology, 19
-
D. Su, Stephanie Smith, M. Preti, P. Schwartz, T. Rutherford, G. Menato, S. Danese, Shenglin Ma, Herbert Yu, D. Katsaros (2009)
Stathmin and tubulin expression and survival of ovarian cancer patients receiving platinum treatment with and without paclitaxelCancer, 115
-
S. Honoré, E. Pasquier, D. Braguer (2005)
Understanding microtubule dynamics for improved cancer therapyCellular and Molecular Life Sciences CMLS, 62
-
R. Ravelli, B. Gigant, P. Curmi, I. Jourdain, S. Lachkar, A. Sobel, Marcel Knossow (2004)
Insight into tubulin regulation from a complex with colchicine and a stathmin-like domainNature, 428
-
H. Salvesen, Soma Das, Lars Akslen (2000)
Loss of nuclear p16 protein expression is not associated with promoter methylation but defines a subgroup of aggressive endometrial carcinomas with poor prognosis.Clinical cancer research : an official journal of the American Association for Cancer Research, 6 1
-
Ray-Hwang Yuan, Y. Jeng, H-l Chen, P. Lai, H. Pan, F. Hsieh, C.-Y. Lin, P-H Lee, H. Hsu (2006)
Stathmin overexpression cooperates with p53 mutation and osteopontin overexpression, and is associated with tumour progression, early recurrence, and poor prognosis in hepatocellular carcinomaThe Journal of Pathology, 209
-
W. Feng (2008)
Inhibitory effects of ASODN of stathmin gene on cultured Eca109 cell linesJournal of Zhengzhou University
-
M. Kuo, Huei-Shyong Wang, Quang-Ting Kuo, C. Shun, H. Hsu, Shi Yang, Ray-Hwang Yuan (2009)
High expression of stathmin protein predicts a fulminant course in medulloblastoma.Journal of neurosurgery. Pediatrics, 4 1
-
W. Xi, Wang Rui, Lin Fang, Dong Ke, G. Ping, Hui-Zhong Zhang (2009)
Expression of stathmin/op18 as a significant prognostic factor for cervical carcinoma patientsJournal of Cancer Research and Clinical Oncology, 135
-
Qiangbin Wang, Yang Xu, Xiaohang Zhao, Yung Chang, Yan Liu, Lijing Jiang, J. Sharma, D. Seo, Hao Yan (2007)
A facile one-step in situ functionalization of quantum dots with preserved photoluminescence for bioconjugation.Journal of the American Chemical Society, 129 20
-
Bedrick Gadea, J. Ruderman (2006)
Aurora B is required for mitotic chromatin-induced phosphorylation of Op18/Stathmin.Proceedings of the National Academy of Sciences of the United States of America, 103 12
-
Po-Wen Chen, Sue‐Jane Lin, S. Tsai, Jiun-Han Lin, Mei-Ru Chen, Jiin-Tarng Wang, Chung-Pei Lee, Ching-Hwa Tsai (2010)
Regulation of Microtubule Dynamics through Phosphorylation on Stathmin by Epstein-Barr Virus Kinase BGLF4*The Journal of Biological Chemistry, 285
-
D. Lin, X-L Du, M-R Wang (2009)
Protein alterations in ESCC and clinical implications: a review.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 22 1
-
M. Steinmetz (2007)
Structure and thermodynamics of the tubulin-stathmin interaction.Journal of structural biology, 158 2
-
L. Gan, K. Guo, Yan Li, X. Kang, Lu Sun, H. Shu, Yin‐kun Liu (2010)
Up-regulated expression of stathmin may be associated with hepatocarcinogenesis.Oncology reports, 23 4
-
A. Cheng, Wei-guo Huang, Zhuchu Chen, Fang Peng, Pengfei Zhang, Maoyu Li, Feng Li, Jianling Li, Cui Li, Hong Yi, B. Yi, Zhi-Qiang Xiao (2008)
Identification of Novel Nasopharyngeal Carcinoma Biomarkers by Laser Capture Microdissection and Proteomic AnalysisClinical Cancer Research, 14
-
Kazuhide Takahashi, Katsuo Suzuki (2009)
Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates phosphorylation and recruitment of stathmin/Op18 to Pak1-WAVE2-kinesin complex.Cellular signalling, 21 5
-
A. Jemal, R. Siegel, Elizabeth Ward, Y. Hao, Jiaquan Xu, M. Thun (2009)
Cancer Statistics, 2009CA: A Cancer Journal for Clinicians, 59
-
S. Rana, P. Maples, N. Senzer, J. Nemunaitis (2008)
Stathmin 1: a novel therapeutic target for anticancer activityExpert Review of Anticancer Therapy, 8
-
S. Mistry, Alexander Bank, G. Atweh (2007)
Synergistic Antiangiogenic Effects of Stathmin Inhibition and Taxol ExposureMolecular Cancer Research, 5
-
B. Antonsson, D. Kassel, E. Ruchti, G. Grenningloh (2001)
Differences in phosphorylation of human and chicken stathmin by MAP kinaseJournal of Cellular Biochemistry, 80
-
Jae Kim, C. Harvard, L. You, Zhidong Xu, K. Kuchenbecker, R. Baehner, D. Jablons (2007)
Stathmin is overexpressed in malignant mesothelioma.Anticancer research, 27 1A
-
J. Trovik, E. Wik, I. Stefansson, J. Marcickiewicz, S. Tingulstad, A. Staff, Tormund Njølstad, I. Vandenput, F. Amant, L. Akslen, H. Salvesen (2011)
Stathmin Overexpression Identifies High-Risk Patients and Lymph Node Metastasis in Endometrial CancerClinical Cancer Research, 17
-
Zhihe Liu, Huimei Lu, Honglian Shi, Yuchun Du, Jian Yu, Sheng Gu, Xian Chen, K. Liu, Chien-An Hu (2005)
PUMA overexpression induces reactive oxygen species generation and proteasome-mediated stathmin degradation in colorectal cancer cells.Cancer research, 65 5
-
L. Cassimeris (2002)
The oncoprotein 18/stathmin family of microtubule destabilizers.Current opinion in cell biology, 14 1
-
Wang (2007)
Expression and significance of stathmin in esophageal squamous cell carcinomaJ Basic Clin Oncol, 120
-
中嶋 大 (2007)
Protein expression profiling identifies maspin and stathmin as potential biomarkers of adenoid cystic carcinoma of the salivary glands -
P. Björklund, K. Cupisti, M. Fryknäs, A. Isaksson, H. Willenberg, G. Åkerström, P. Hellman, G. Westin (2009)
Stathmin as a marker for malignancy in pheochromocytomas.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 118 1
-
Y. Kouzu, K. Uzawa, Hirofumi Koike, Kengo Saito, D. Nakashima, M. Higo, Yosuke Endo, A. Kasamatsu, M. Shiiba, H. Bukawa, H. Yokoe, H. Tanzawa (2006)
Overexpression of stathmin in oral squamous-cell carcinoma: correlation with tumour progression and poor prognosisBritish Journal of Cancer, 94
-
(2000)
Spindle assembly and the art of regulating microtubule dynamics by MAPs and Stathmin/Op18 -
G. Paolo, B. Antonsson, Daniel Kassel, B. Riederer, G. Grenningloh (1997)
Phosphorylation regulates the microtubule‐destabilizing activity of stathmin and its interaction with tubulinFEBS Letters, 416
-
Yulin Sun, W. Mi, J. Cai, W. Ying, Fang Liu, Haizhen Lu, Y. Qiao, W. Jia, X. Bi, N. Lu, Shangmei Liu, X. Qian, Xiaohang Zhao (2008)
Quantitative proteomic signature of liver cancer cells: tissue transglutaminase 2 could be a novel protein candidate of human hepatocellular carcinoma.Journal of proteome research, 7 9
-
Tae-Yong Jeon, Myoung-Eun Han, Young-Suk Lee, Yong Lee, Gwang Kim, Geun-Am Song, Hur Gy, Joo Kim, Hyun Kim, Sik Yoon, S. Baek, Bong‐Seon Kim, Jae Kim, Sae-Ock Oh (2010)
Overexpression of stathmin1 in the diffuse type of gastric cancer and its roles in proliferation and migration of gastric cancer cellsBritish Journal of Cancer, 102
-
F. Moreno, J. Ávila (1998)
Phosphorylation of stathmin modulates its function as a microtubule depolymerizing factorMolecular and Cellular Biochemistry, 183
-
T. Manna, D. Thrower, S. Honnappa, M. Steinmetz, L. Wilson (2009)
Regulation of Microtubule Dynamic Instability in Vitro by Differentially Phosphorylated Stathmin*The Journal of Biological Chemistry, 284
-
Feng Wang, Liuhang Wang, Wei He, Li-Na Zhu, Pei-rong Zhao, Q. Fan (2010)
[Expression of stathmin in esophageal squamous cell carcinoma and its biological significance].Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 30 7
-
U. Marklund, N. Larsson, H. Gradin, G. Brattsand, M. Gullberg (1996)
Oncoprotein 18 is a phosphorylation‐responsive regulator of microtubule dynamics.The EMBO Journal, 15
-
E. Cernuda-Morollón, J. Millán, M. Shipman, F. Marelli-Berg, A. Ridley (2010)
Rac Activation by the T-Cell Receptor Inhibits T Cell MigrationPLoS ONE, 5
-
L. Belmont, T. Mitchison (1996)
Identification of a Protein That Interacts with Tubulin Dimers and Increases the Catastrophe Rate of MicrotubulesCell, 84
-
Wei-Chou Lin, Shyh‐Chyan Chen, F. Hu, S. Chueh, Y. Pu, Hong‐Jeng Yu, Kuo-How Huang (2009)
Expression of stathmin in localized upper urinary tract urothelial carcinoma: correlations with prognosis.Urology, 74 6
-
Fei Liu, Fang Liu, Yulin Sun, Xiaohang Zhao (2010)
Significance of STMN1 expression in esophageal squamous cell carcinomaWorld Chinese Journal of Digestology, 18
- Publisher
- Spandidos Publications
- Copyright
- Copyright © Spandidos Publications
- ISSN
- 1021-335X
- eISSN
- 1791-2431
- DOI
- 10.3892/or.2012.2157
- pmid
- 23229199
- Publisher site
- See Article on Publisher Site
Abstract
Microtubules play extensive roles in cellular processes, including cell motility. Stathmin is an important protein which destabilizes microtubules. The essential function of stathmin is closely associated with its phosphorylation status. Stathmin is overexpressed in many human cancers and has a significant relationship with clinical characteristics such as grade, tumor size and prognosis. We demonstrated that stathmin was overexpressed in ESCC tissues using both 2-DE and immunohistochemistry analysis. In addition, overexpression of stathmin was significantly correlated with histological grade in ESCC. However, no correlation was found with age, gender and lymph node metastasis. Knockdown of stathmin with siRNA impaired cell migration in KYSE30 and KYSE410 cells. When EC0156 cells were treated with paclitaxel, stathmin was stably phosphorylated and migration was impaired. These observations suggest that stathmin may have a more important function in ESCC development and migration. The present study provides further understanding of the importance of stathmin in ESCC therapy or diagnosis.
Journal
Oncology Reports – Spandidos Publications
Published: Feb 1, 2013