Access the full text.
Sign up today, get DeepDyve free for 14 days.
(1994)
Mutant p 53 increases radioresistance in rat embryo fibroblasts simultaneously transfected with HPV 16E 7 and / or activated Hras
K. Kami, R. Doi, M. Koizumi, E. Toyoda, Tomohiko Mori, D. Ito, Y. Kawaguchi, K. Fujimoto, M. Wada, S. Miyatake, M. Imamura (2005)
Downregulation of survivin by siRNA diminishes radioresistance of pancreatic cancer cells.Surgery, 138 2
S. Riedl, M. Renatus, R. Schwarzenbacher, Qiao Zhou, Chaohong Sun, S. Fesik, R. Liddington, G. Salvesen (2001)
Structural Basis for the Inhibition of Caspase-3 by XIAPCell, 104
E. LaCasse, S. Baird, R. Korneluk, A. MacKenzie (1998)
The inhibitors of apoptosis (IAPs) and their emerging role in cancerOncogene, 17
A. Takahashi, H. Matsumoto, K. Yuki, J. Yasumoto, Atsuhisa Kajiwara, M. Aoki, Y. Furusawa, K. Ohnishi, T. Ohnishi (2004)
High-LET radiation enhanced apoptosis but not necrosis regardless of p53 status.International journal of radiation oncology, biology, physics, 60 2
J. Lotem, L. Sachs (1993)
Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells.Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 4 1
K. Ohnishi, Ichiro Ota, A. Takahashi, K. Yane, Hideki Matsumoto, Takeo Ohnishi (2002)
Transfection of mutant p53 gene depresses X-ray- or CDDP-induced apoptosis in a human squamous cell carcinoma of the head and neckApoptosis, 7
J. Lotem, L. Sachs (1994)
Control of sensitivity to induction of apoptosis in myeloid leukemic cells by differentiation and bcl-2 dependent and independent pathways.Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 5 3
Y. Suzuki, Y. Nakabayashi, K. Nakata, John Reed, R. Takahashi (2001)
X-linked Inhibitor of Apoptosis Protein (XIAP) Inhibits Caspase-3 and -7 in Distinct Modes*The Journal of Biological Chemistry, 276
R. Perona, I. Sánchez-Pérez (2004)
Control of oncogenesis and cancer therapy resistanceBritish Journal of Cancer, 90
Hai-tao Guan, Xing-huan Xue, Zhijun Dai, Xi-jing Wang, Ang Li, Zhao-yin Qin (2006)
Down-regulation of survivin expression by small interfering RNA induces pancreatic cancer cell apoptosis and enhances its radiosensitivity.World journal of gastroenterology, 12 18
C. Cao, Y. Mu, D. Hallahan, B. Lu (2004)
XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancerOncogene, 23
I. Tamm, S. Richter, Doreen Oltersdorf, U. Creutzig, J. Harbott, Frank Scholz, L. Karawajew, W. Ludwig, C. Wuchter (2004)
High Expression Levels of X-Linked Inhibitor of Apoptosis Protein and Survivin Correlate with Poor Overall Survival in Childhood de Novo Acute Myeloid LeukemiaClinical Cancer Research, 10
K. Ohnishi, I. Ota, A. Takahashi, T. Ohnishi (2000)
Glycerol restores p53-dependent radiosensitivity of human head and neck cancer cells bearing mutant p53British Journal of Cancer, 83
M. Kappler, H. Taubert, F. Bartel, K. Blümke, Matti Panian, H. Schmidt, J. Dunst, M. Bache (2005)
Radiosensitization, after a combined treatment of survivin siRNA and irradiation, is correlated with the activation of caspases 3 and 7 in a wt-p53 sarcoma cell line, but not in a mt-p53 sarcoma cell line.Oncology reports, 13 1
F. Rödel, J. Hoffmann, L. Distel, M. Herrmann, Timmo Noisternig, T. Papadopoulos, R. Sauer, C. Rödel (2005)
Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer.Cancer research, 65 11
H. Ishikawa, N. Mitsuhashi, H. Sakurai, K. Maebayashi, H. Niibe (2001)
The effects of p53 status and human papillomavirus infection on the clinical outcome of patients with Stage IIIB cervical carcinoma treated with radiation therapy aloneCancer, 91
D. Kim, Sung Seo, Samuel Cho, S. Chang, Ho Lee, S. Lee, J. Block, T. Hei, Francis Lee (2007)
Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cellsJournal of Orthopaedic Research, 25
A. Baldwin (2001)
Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κBJournal of Clinical Investigation, 107
K. Ohnishi, Z. Scuric, R. Schiestl, N. Okamoto, A. Takahashi, T. Ohnishi (2006)
siRNA Targeting NBS1 or XIAP Increases Radiation Sensitivity of Human Cancer Cells Independent of TP53 Status, 166
O. Inanami, K. Takahashi, M. Kuwabara (1999)
Attenuation of caspase-3-dependent apoptosis by Trolox post-treatment of X-irradiated MOLT-4 cells.International journal of radiation biology, 75 2
J. Yano, K. Hirabayashi, Shin-ichiro Nakagawa, Tohru Yamaguchi, M. Nogawa, Isao Kashimori, H. Naito, H. Kitagawa, K. Ishiyama, T. Ohgi, T. Irimura (2004)
Antitumor Activity of Small Interfering RNA/Cationic Liposome Complex in Mouse Models of CancerClinical Cancer Research, 10
Y. Harima, K. Harima, N. Shikata, A. Oka, T. Ohnishi, Yoshimasa Tanaka (1998)
Bax and Bcl-2 expressions predict response to radiotherapy in human cervical cancerJournal of Cancer Research and Clinical Oncology, 124
Runzhao Li, P. Sutphin, D. Schwartz, Devorah Matas, N. Almog, R. Wolkowicz, N. Goldfinger, H. Pei, M. Prokocimer, V. Rotter (1998)
Mutant p53 protein expression interferes with p53-independent apoptotic pathwaysOncogene, 16
S. Hara, S. Nakashima, T. Kiyono, M. Sawada, S. Yoshimura, T. Iwama, N. Sakai (2004)
Ceramide triggers caspase activation during gamma-radiation-induced apoptosis of human glioma cells lacking functional p53.Oncology reports, 12 1
I. Ota, K. Ohnishi, A. Takahashi, K. Yane, H. Kanata, H. Miyahara, T. Ohnishi, H. Hosoi (2000)
Transfection with mutant p53 gene inhibits heat-induced apoptosis in a head and neck cell line of human squamous cell carcinoma.International journal of radiation oncology, biology, physics, 47 2
B. Lu, Y. Mu, C. Cao, Fenghua Zeng, S. Schneider, Jiahui Tan, J. Price, Jun Chen, M. Freeman, D. Hallahan (2004)
Survivin as a therapeutic target for radiation sensitization in lung cancer.Cancer research, 64 8
(2002)
in a human squamous cell carcinoma of the head and neck
Yoon-Jin Lee, D. Chung, Su-Jae Lee, Gil Jhon, Yun‐Sil Lee (2006)
Enhanced radiosensitization of p53 mutant cells by oleamide.International journal of radiation oncology, biology, physics, 64 5
The X-chromosome-linked inhibitor of the apoptosis protein (XIAP) is known to be an inhibitory factor for caspase-3. The aim of our study was to see whether radiation-induced apoptosis is enhanced by RNA interference targeting the XIAP through an elevation of caspase-3 activity, and whether the effect of XIAP depression depends on the p53 status of cancer cells. Two types of transformed human cultured non-small cell lung cancer cells (H1299) were used: wild-type p53-transfected cells (H1299/wtp53) and mutated p53-transfected cells (H1299/mp53). When 21-mer siRNA targeting XIAP (XIAP-siRNA) was transfected into these cells using liposomes, a suppression of the constitutive XIAP protein expression was observed. XIAP-siRNA enhanced radiation sensitivity in H1299/wtp53 and in H1299/mp53 cells and was very effective in H1299/mp53 cells. Radiation-induced apoptosis and the activation of caspase-3 were more elevated by XIAP-siRNA in the H1299/mp53 cells than in H1299/ wtp53. These results suggest that XIAP-siRNA is a possible candidate for a radiation sensitizer in cancer radiotherapy, especially in cells with mutated p53.
Oncology Reports – Spandidos Publications
Published: Jul 1, 2008
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.