Access the full text.
Sign up today, get DeepDyve free for 14 days.
R. Jansen, D. Greenbaum, M. Gerstein (2002)
Relating whole-genome expression data with protein-protein interactions.Genome research, 12 1
Li (2008)
Network-constrained regularization and variable selection for analysis of genomic dataBioinformatics, 24
Glynn Dennis, Brad Sherman, Douglas Hosack, Jun Yang, Wei Gao, H. Lane, R. Lempicki (2003)
DAVID: Database for Annotation, Visualization, and Integrated DiscoveryGenome Biology, 4
Lynn Pouliot, Yu-Chi Chen, J. Bai, R. Guha, Scott Martin, M. Gottesman, M. Hall (2012)
Cisplatin sensitivity mediated by WEE1 and CHK1 is mediated by miR-155 and the miR-15 family.Cancer research, 72 22
C. Zeller, W. Dai, N. Steele, A. Siddiq, A. Walley, C. Wilhelm-Benartzi, S. Rizzo, A. Zee, J. Plumb, Robert Brown, Robert Brown (2012)
Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profilingOncogene, 31
Xi-ping Li, Xu-yi Liu, Jie Wang, Zeng-li Wang, Wei Jiang, E. Reed, Yi Zhang, Yuanlin Liu, Q. Li (2003)
Thalidomide down-regulates the expression of VEGF and bFGF in cisplatin-resistant human lung carcinoma cells.Anticancer research, 23 3B
María Cortés-Sempere, M. Miguel, Olga Pernía, Carmen Rodriguez, J. Carpeño, M. Nistal, E. Conde, F. López-Rios, C. Belda-Iniesta, Rosario Perona, I. Cáceres (2013)
IGFBP-3 methylation-derived deficiency mediates the resistance to cisplatin through the activation of the IGFIR/Akt pathway in non-small cell lung cancerOncogene, 32
Xing-jie Liang, D. Shen, M. Gottesman (2004)
Down-regulation and altered localization of gamma-catenin in cisplatin-resistant adenocarcinoma cells.Molecular pharmacology, 65 5
Ying Teng, Xiuwen Wang, Ya-wei Wang, D. Ma (2010)
Wnt/beta-catenin signaling regulates cancer stem cells in lung cancer A549 cells.Biochemical and biophysical research communications, 392 3
C. Zweier (2011)
Severe Intellectual Disability Associated with Recessive Defects in CNTNAP2 and NRXN1Molecular Syndromology, 2
M. Eisen, P. Spellman, P. Brown, D. Botstein (1998)
Cluster analysis and display of genome-wide expression patterns.Proceedings of the National Academy of Sciences of the United States of America, 95 25
D. Feldman, G. Bosl, J. Sheinfeld, R. Motzer (2008)
Medical treatment of advanced testicular cancer.JAMA, 299 6
Steven Wang, L. Bourguignon (2006)
Hyaluronan-CD44 promotes phospholipase C-mediated Ca2+ signaling and cisplatin resistance in head and neck cancer.Archives of otolaryngology--head & neck surgery, 132 1
X. Chen, Lily Wang (2009)
Integrating Biological Knowledge with Gene Expression Profiles for Survival Prediction of CancerJournal of computational biology : a journal of computational molecular cell biology, 16 2
B. Ryan, N. O'Donovan, M. Duffy (2009)
Survivin: a new target for anti-cancer therapy.Cancer treatment reviews, 35 7
D. Shen, Lynn Pouliot, J. Gillet, Wenting Ma, Alfred Johnson, M. Hall, M. Gottesman (2012)
The transcription factor GCF2 is an upstream repressor of the small GTPAse RhoA, regulating membrane protein trafficking, sensitivity to doxorubicin, and resistance to cisplatin.Molecular pharmaceutics, 9 6
Daan Abel, O. Michel, R. Veerhuis, Marlies Jacobs, M. Dijk, C. Oudejans (2012)
Direct downregulation of CNTNAP2 by STOX1A is associated with Alzheimer's disease.Journal of Alzheimer's disease : JAD, 31 4
Seok-Jun Kim, Ji‐Young Shin, Teak-Chin Cheong, I. Choi, Yeon-Su Lee, S. Park, Kyung-Hee Chun (2011)
Galectin-3 germline variant at position 191 enhances nuclear accumulation and activation of β-catenin in gastric cancerClinical & Experimental Metastasis, 28
Purvesh Khatri, S. Drăghici, G. Ostermeier, Stephen Krawetz (2002)
Profiling gene expression using onto-express.Genomics, 79 2
M. Ashburner, C. Ball, J. Blake, D. Botstein, Heather Butler, J. Cherry, A. Davis, K. Dolinski, S. Dwight, J. Eppig, M. Harris, D. Hill, L. Issel-Tarver, A. Kasarskis, S. Lewis, J. Matese, J. Richardson, M. Ringwald, G. Rubin, G. Sherlock (2000)
Gene Ontology: tool for the unification of biologyNature Genetics, 25
J. Boyer, W. Allen, E. McLean, P. Wilson, A. McCulla, S. Moore, D. Longley, C. Caldas, P. Johnston (2006)
Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer.Cancer research, 66 5
N. Xu, Cong-huan Shen, Yi Luo, Lei-Lei Xia, F. Xue, Q. Xia, Jianjun Zhang (2012)
Upregulated miR-130a increases drug resistance by regulating RUNX3 and Wnt signaling in cisplatin-treated HCC cell.Biochemical and biophysical research communications, 425 2
V. Spirin, L. Mirny (2003)
Protein complexes and functional modules in molecular networksProceedings of the National Academy of Sciences of the United States of America, 100
Gene Consortium (2005)
The Gene Ontology (GO) project in 2006Nucleic Acids Research, 34
D. Stewart (2007)
Mechanisms of resistance to cisplatin and carboplatin.Critical reviews in oncology/hematology, 63 1
BIOINFORMATICS ORIGINAL PAPER doi:10.1093/bioinformatics/btn081 Systems biology Network-constrained regularization and variable selection for analysis of genomic data
Yu-Xia Chen, Yan Wang, C. Fu, Fei Diao, Liang-Nian Song, Zong-bin Li, Rui Yang, Jian Lu (2010)
Dexamethasone enhances cell resistance to chemotherapy by increasing adhesion to extracellular matrix in human ovarian cancer cells.Endocrine-related cancer, 17 1
L. Fang, L. Fang, L. Fang, Z. Deng, Z. Deng, T. Shatseva, T. Shatseva, Jie Yang, C. Peng, W. Du, A. Yee, L. Ang, Chengyan He, S. Shan, S. Shan, Burton Yang, Burton Yang (2011)
MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8Oncogene, 30
Maggie Tang, H. Zhou, J. Yam, A. Wong (2010)
c-Met overexpression contributes to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2.Neoplasia, 12 2
A. Brozovic, G. Fritz, M. Christmann, J. Zisowsky, U. Jaehde, M. Osmak, B. Kaina (2004)
Long‐term activation of SAPK/JNK, p38 kinase and fas‐L expression by cisplatin is attenuated in human carcinoma cells that acquired drug resistanceInternational Journal of Cancer, 112
L. Galluzzi, L. Senovilla, L. Senovilla, L. Senovilla, I. Vitale, I. Vitale, I. Vitale, J. Michels, J. Michels, J. Michels, I. Martins, I. Martins, I. Martins, O. Kepp, O. Kepp, O. Kepp, M. Castedo, M. Castedo, M. Castedo, G. Kroemer (2012)
Molecular mechanisms of cisplatin resistanceOncogene, 31
S. Drăghici, P. Khatri, R. Martins, G. Ostermeier, S. Krawetz (2003)
Global functional profiling of gene expression.Genomics, 81 2
Ming Yuan, P. Luong, C. Hudson, K. Gudmundsdottir, S. Basu (2010)
c-Abl phosphorylation of ΔNp63α is critical for cell viabilityCell Death & Disease, 1
J. Zhang, S. Wiemann (2009)
KEGGgraph: a graph approach to KEGG PATHWAY in R and bioconductorBioinformatics, 25
Dennis (2003)
DAVID: Database for Annotation, Visualization, and Integrated DiscoveryGenome Biol, 4
A. Poduri, A. Poduri, S. Chopra, S. Chopra, S. Chopra, E. Neilan, E. Neilan, P. Elhosary, M. Kurian, M. Kurian, E. Meyer, B. Barry, O. Khwaja, Omar Khwaja, M. Salih, T. Stödberg, I. Scheffer, Eamonn Maher, M. Sahin, Bai-Lin Wu, G. Berry, G. Berry, C. Walsh, J. Picker, J. Picker, S. Kothare, S. Kothare (2012)
Homozygous PLCB1 deletion associated with malignant migrating partial seizures in infancyEpilepsia, 53
V. Vasco, Giuseppina Cardinale, P. Polonia (2011)
Deletion of PLCB1 gene in schizophrenia-affected patientsJournal of Cellular and Molecular Medicine, 16
R. Lovering, E. Camon, J. Blake, A. Diehl (2008)
Access to immunology through the Gene OntologyImmunology, 125
桝本 直子 (2004)
v-src induces cisplatin resistance by increasing the repair of cisplatin-DNA interstrand cross-links in human gallbladder adenocarcinoma cells
Heng-Hsiung Wu, Jeng-Yuan Wu, Ya‐Wen Cheng, Chi-yi Chen, Ming-Ching Lee, Y. Goan, Hue Lee (2010)
cIAP2 Upregulated by E6 Oncoprotein via Epidermal Growth Factor Receptor/Phosphatidylinositol 3-Kinase/AKT Pathway Confers Resistance to Cisplatin in Human Papillomavirus 16/18–Infected Lung CancerClinical Cancer Research, 16
Z. Liu, C. Sun, Y. Zhang, Z. Ji, G. Yang (2011)
Phosphatidylinositol 3-Kinase-C2β Inhibits Cisplatin-Mediated Apoptosis via the Akt Pathway in Oesophageal Squamous Cell CarcinomaJournal of International Medical Research, 39
Lingyun Yang, Ningwei Li, Hongjing Wang, Xi-biao Jia, Xue Wang, Juan Luo (2012)
Altered microRNA expression in cisplatin-resistant ovarian cancer cells and upregulation of miR-130a associated with MDR1/P-glycoprotein-mediated drug resistance.Oncology reports, 28 2
Y. Wang, P. Nangia-Makker, V. Balan, V. Hogan, A. Raz (2010)
Calpain activation through galectin-3 inhibition sensitizes prostate cancer cells to cisplatin treatmentCell Death & Disease, 1
Xingjie Liang, Youguo Huang (2001)
Alteration of membrane lipid biophysical properties and resistance of human lung adenocarcinoma A549 cells to cisplatinScience in China Series C: Life Sciences, 44
Zhi Wei, Hongzhe Li (2007)
A Markov random field model for network-based analysis of genomic dataBioinformatics, 23 12
V. Janson, B. Andersson, P. Behnam-Motlagh, K. Engström, R. Henriksson, K. Grankvist (2008)
Acquisition of Cisplatin-resistance in Malignant Mesothelioma Cells Abrogates Na+,K+,2Cl-;-cotransport Activity and Cisplatin-induced Early Membrane BlebbingCellular Physiology and Biochemistry, 22
N. Masumoto, S. Nakano, H. Fujishima, K. Kohno, Y. Niho (1999)
v‐src induces cisplatin resistance by increasing the repair of cisplatin–DNA interstrand cross‐links in human gallbladder adenocarcinoma cellsInternational Journal of Cancer, 80
Cisplatin-based chemotherapy is the standard therapy used for the treatment of several types of cancer. However, its efficacy is largely limited by the acquired drug resistance. To date, little is known about the RNA expression changes in cisplatin-resistant cancers. Identification of the RNAs related to cisplatin resistance may provide specific insight into cancer therapy. In the present study, expression profiling of 7 cancer cell lines was performed using oligonucleotide microarray analysis data obtained from the GEO database. Bioinformatic analyses such as the Gene Ontology (GO) and KEGG pathway were used to identify genes and pathways specifically associated with cisplatin resistance. A signal transduction network was established to identify the core genes in regulating cancer cell cisplatin resistance. A number of genes were differentially expressed in 7 groups of cancer cell lines. They mainly participated in 85 GO terms and 11 pathways in common. All differential gene interactions in the Signal-Net were analyzed. CTNNB1, PLCG2 and SRC were the most significantly altered. With the use of bioinformatics, large amounts of data in microarrays were retrieved and analyzed by means of thorough experimental planning, scientific statistical analysis and collection of complete data on cancer cell cisplatin resistance. In the present study, a novel differential gene expression pattern was constructed and further study will provide new targets for the diagnosis and mechanisms of cancer cisplatin resistance.
Oncology Reports – Spandidos Publications
Published: Aug 1, 2013
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.