Access the full text.
Sign up today, get DeepDyve free for 14 days.
Janet Lee, Jean-Charles Soria, Khaled Hassan, Diane Liu, Ximing Tang, Adel El-Naggar, W. Hong, Li Mao (2001)
Loss of Fhit expression is a predictor of poor outcome in tongue cancer.Cancer research, 61 3
S. Zöchbauer-Müller, Kwun Fong, Anirban Maitra, Stephen Lam, Joseph Geradts, R. Ashfaq, A. Virmani, S. Milchgrub, A. Gazdar, J. Minna (2001)
5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer.Cancer research, 61 9
Anjilna Wali, R. Srinivasan, Mir Shabnam, S. Majumdar, K. Joshi, D. Behera (2006)
Loss of Fragile Histidine Triad Gene Expression in Advanced Lung Cancer Is Consequent to Allelic Loss at 3p14 Locus and Promoter MethylationMolecular Cancer Research, 4
(2002)
Frequent 3 p allele loss and epigenetic inactivation of the RASSF 1 A tumour suppressor gene from region 3 p 21 . 3 in head and neck squamous cell carcinoma
A. Kisielewski, G. Xiao, S. Liu, Andres Klein-Szanto, M. Novara, J. Sina, K. Bleicher, R. Yeung, T. Goodrow (1998)
Analysis of the FHIT gene and its product in squamous cell carcinomas of the head and neckOncogene, 17
J. Califano, G. Clayman, D. Sidransky, W. Koch, S. Piantadosi, Peter Riet, Homaira Nawroz, W. Westra, R. Corio (1996)
Poster 7: A Genetic Progression Model for Head and Neck Cancer: Implications for Field CancerizationOtolaryngology- Head and Neck Surgery, 115
H. Rowley, A. Jones, D. Spandidos, J. Field (1996)
Definition of a tumor suppressor gene locus on the short arm of chromosome 3 in squamous cell carcinoma of the head and neck by means of microsatellite markers.Archives of otolaryngology--head & neck surgery, 122 5
T. Segawa, T. Sasagawa, K. Saijoh, M. Inoue (2000)
Clinicopathological significance of fragile histidine triad transcription protein expression in endometrial carcinomas.Clinical cancer research : an official journal of the American Association for Cancer Research, 6 6
P. Riet, Homaira Nawroz, R. Hruban, R. Corio, K. Tokino, W. Koch, D. Sidransky (1994)
Frequent loss of chromosome 9p21-22 early in head and neck cancer progression.Cancer research, 54 5
J. Jeannon, J. Soames, V. Aston, F. Stafford, J. Wilson (2004)
Molecular markers in dysplasia of the larynx: expression of cyclin-dependent kinase inhibitors p21, p27 and p53 tumour suppressor gene in predicting cancer risk.Clinical otolaryngology and allied sciences, 29 6
Atsushi Kitamura, K. Yashima, E. Okamoto, H. Andachi, A. Hosoda, Y. Kishimoto, G. Shiota, Hisao Ito, N. Kaibara, H. Kawasaki (2001)
Reduced Fhit Expression Occurs in the Early Stage of Esophageal Tumorigenesis: No Correlation with p53 Expression and ApoptosisOncology, 61
C. Sherr, James Roberts (1999)
CDK inhibitors: positive and negative regulators of G1-phase progression.Genes & development, 13 12
L. Barnes, P. Garrison, Z. Siprashvili, A. Guranowski, A. Robinson, S. Ingram, C. Croce, M. Ohta, K. Huebner (1996)
Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase.Biochemistry, 35 36
S. Hayashi, K. Tanimoto, Kyoko Hajiro-Nakanishi, E. Tsuchiya, M. Kurosumi, Y. Higashi, K. Imai, K. Suga, K. Nakachi (1997)
Abnormal FHIT transcripts in human breast carcinomas: a clinicopathological and epidemiological analysis of 61 Japanese cases.Cancer research, 57 10
Y. Tomizawa, T. Nakajima, T. Kohno, R. Saito, N. Yamaguchi, J. Yokota (1998)
Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma.Cancer research, 58 23
(1999)
The tumorsuppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control
H. Mineta, K. Miura, S. Takebayashi, K. Misawa, Y. Ueda, I. Suzuki, M. Ito, J. Wennerberg (2003)
Low expression of fragile histidine triad gene correlates with high proliferation in head and neck squamous cell carcinoma.Oral oncology, 39 1
L. Virgilio, Michele Shuster, S. Gollin, M. Veronese, M. Ohta, K. Huebner, C. Croce (1996)
FHIT gene alterations in head and neck squamous cell carcinomas.Proceedings of the National Academy of Sciences of the United States of America, 93 18
C. Mascaux, B. Martin, J. Verdebout, A. Meert, V. Ninane, J. Sculier (2003)
Fragile histidine triad protein expression in nonsmall cell lung cancer and correlation with Ki-67 and with p53European Respiratory Journal, 21
C. Garnis, Corisande Baldwin, Lewei Zhang, M. Rosin, W. Lam (2003)
Use of complete coverage array comparative genomic hybridization to define copy number alterations on chromosome 3p in oral squamous cell carcinomas.Cancer research, 63 24
Z. Gatalica, S. Lele, B. Rampy, B. Norris (2000)
The expression of Fhit protein is related inversely to disease progression in patients with breast carcinomaCancer, 88
K. Tanimoto, S. Hayashi, E. Tsuchiya, Y. Tokuchi, Y. Kobayashi, K. Yoshiga, T. Okui, M. Kobayashi, Takeshi Ichikawa (2000)
Abnormalities of the FHIT gene in human oral carcinogenesisBritish Journal of Cancer, 82
H. Tanaka, Y. Shimada, H. Harada, M. Shinoda, S. Hatooka, M. Imamura, K. Ishizaki (1998)
Methylation of the 5' CpG island of the FHIT gene is closely associated with transcriptional inactivation in esophageal squamous cell carcinomas.Cancer research, 58 15
M. Ohta, H. Inoue, M. Cotticelli, K. Kastury, R. Baffa, J. Palazzo, Z. Siprashvili, M. Mori, P. Mccue, T. Druck, C. Croce, K. Huebner (1996)
The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract CancersCell, 84
Homaira Nawroz, P. Riet, R. Hruban, W. Koch, J. Ruppert, D. Sidransky (1994)
Allelotype of head and neck squamous cell carcinoma.Cancer research, 54 5
(1996)
The FHIT gene 3 p 14 . 2 is abnormal in
Kuo-Wei Chang, S. Kao, R. Tzeng, Chung-Ji Liu, A. Cheng, Shun‐Chun Yang, Y. Wong, Shu-Chun Lin (2002)
Multiple molecular alterations of FHIT in betel‐associated oral carcinomaThe Journal of Pathology, 196
J. Califano, W. Westra, G. Meininger, R. Corio, W. Koch, D. Sidransky (2000)
Genetic progression and clonal relationship of recurrent premalignant head and neck lesions.Clinical cancer research : an official journal of the American Association for Cancer Research, 6 2
(2005)
General Rules of Clinical Studies on Head and Neck Cancer
The fragile histidine triad (FHIT), frequently lost in many cancers, was identified as a candidate tumor suppressor gene at chromosome 3p locus 14.2. Loss of the FHIT protein because of the alteration or loss of heterozygosity by genetic deletion occurs in a variety of epithelial tumors including head and neck cancer. However, the biological function of the FHIT protein is still unknown and its role in intrinsic cellular proliferation remains particularly controversial in preinvasive lesions and invasive tumors of the head and neck. To clarify the role of the FHIT protein in laryngeal squamous cell carcinoma (LSCC) and to examine whether the expression of FHIT could be a prognostic parameter for laryngeal carcinogenesis, we investigated the relationship between the expression of the FHIT protein, other tumor suppressor gene products (p53 and p16), the cellular proliferation marker (Ki-67) and the survival time of patients with LSCC. In our study, there were significant differences (p<0.05) in the expression of FHIT between low grade dysplasia and LSCC. Additionally, survival time analysis showed a significant correlation between the reduction of FHIT expression and the length of disease-free survival (p<0.05) in patients with T1-T2 N0 laryngeal carcinoma. However, we did not confirm a relationship between the expression of FHIT, the other tumor suppressor gene products (p53 and p16) or the cellular proliferation marker (Ki-67). In conclusion, we provided evidence that the reduction of FHIT levels may be a useful prognostic indicator for the clinical outcome of laryngeal SCC. Our findings indicated that FHIT utilizes a pathway independent of p53 and is involved in abnormal cell proliferation via the breakdown of G0-G1 arrest in the larynx and apoptosis during multistep carcinogenesis of the larynx.
Oncology Reports – Spandidos Publications
Published: Apr 1, 2008
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.