Access the full text.
Sign up today, get DeepDyve free for 14 days.
A. Anttonen, M. Kajanti, P. Heikkilä, M. Jalkanen, H. Joensuu (1999)
Syndecan-1 expression has prognostic significance in head and neck carcinomaBritish Journal of Cancer, 79
C. Ricciardelli, K. Mayne, P. Sykes, W. Raymond, Kieran McCaul, Villis Marshall, D. Horsfall (1998)
Elevated levels of versican but not decorin predict disease progression in early-stage prostate cancer.Clinical cancer research : an official journal of the American Association for Cancer Research, 4 4
J. Kodama, Hasengaowa, T. Kusumoto, N. Seki, T. Matsuo, Y. Ojima, K. Nakamura, A. Hongo, Y. Hiramatsu (2006)
Prognostic significance of stromal versican expression in human endometrial cancer.Annals of oncology : official journal of the European Society for Medical Oncology, 18 2
E. Davies, F. Blackhall, J. Shanks, G. David, A. McGown, R. Swindell, R. Slade, P. Martin-Hirsch, J. Gallagher, G. Jayson (2004)
Distribution and Clinical Significance of Heparan Sulfate Proteoglycans in Ovarian CancerClinical Cancer Research, 10
T. Wight, M. Kinsella, E. Qwarnström (1992)
The role of proteoglycans in cell adhesion, migration and proliferationCurrent Biology, 2
(1992)
Biology of syndecans
D. Carey (1997)
Syndecans: multifunctional cell-surface co-receptors.The Biochemical journal, 327 ( Pt 1)
Ralph Sanderson, M. Hinkes, Merton Bernfield (1992)
Syndecan-1, a cell-surface proteoglycan, changes in size and abundance when keratinocytes stratify.The Journal of investigative dermatology, 99 4
R. Casey, T. Oegema, K. Skubitz, S. Pambuccian, S. Grindle, A. Skubitz (2004)
Cell membrane glycosylation mediates the adhesion, migration, and invasion of ovarian carcinoma cellsClinical & Experimental Metastasis, 20
N. Schwartz, E. Pirok, James Mensch, M. Domowicz (1999)
Domain organization, genomic structure, evolution, and regulation of expression of the aggrecan gene family.Progress in nucleic acid research and molecular biology, 62
Masato Kato, Scott Saunders, Hungq Nguyen, Merton Bernfieldt (1995)
Loss of cell surface syndecan-1 causes epithelia to transform into anchorage-independent mesenchyme-like cells.Molecular biology of the cell, 6 5
M. Stanley, M. Stanley, R. Sanderson, R. Zera (1999)
Syndecan-1 expression is induced in the stroma of infiltrating breast carcinoma.American journal of clinical pathology, 112 3
M. Dours-Zimmermann, D. Zimmermann (1994)
A novel glycosaminoglycan attachment domain identified in two alternative splice variants of human versican.The Journal of biological chemistry, 269 52
S. Leppa, Markku Mali, H. Miettinen, M. Jalkanen (1992)
Syndecan expression regulates cell morphology and growth of mouse mammary epithelial tumor cells.Proceedings of the National Academy of Sciences of the United States of America, 89
Hasengaowa, J. Kodama, T. Kusumoto, Y. Shinyo, N. Seki, Yuji Hiramatsu (2005)
Prognostic significance of syndecan-1 expression in human endometrial cancer.Annals of oncology : official journal of the European Society for Medical Oncology, 16 7
A. Theocharis, M. Tsara, N. Papageorgacopoulou, Dionisis Karavias, D. Theocharis (2000)
Pancreatic carcinoma is characterized by elevated content of hyaluronan and chondroitin sulfate with altered disaccharide composition.Biochimica et biophysica acta, 1502 2
L. Shah, Kristin Walter, A. Borczuk, S. Kawut, J. Sonett, L. Gorenstein, M. Ginsburg, K. Steinglass, C. Powell (2004)
Expression of syndecan‐1 and expression of epidermal growth factor receptor are associated with survival in patients with nonsmall cell lung carcinomaCancer, 101
L. Ang, Y. Zhang, L. Cao, B. Yang, B. Young, C. Kiani, V. Lee, K. Allan, B. Yang (1999)
Versican enhances locomotion of astrocytoma cells and reduces cell adhesion through its G1 domain.Journal of neuropathology and experimental neurology, 58 6
K. Harada, S. Masuda, M. Hirano, Y. Nakanuma (2003)
Reduced expression of syndecan-1 correlates with histologic dedifferentiation, lymph node metastasis, and poor prognosis in intrahepatic cholangiocarcinoma.Human pathology, 34 9
M. Leivonen, J. Lundin, S. Nordling, K. Boguslawski, C. Haglund (2004)
Prognostic Value of Syndecan-1 Expression in Breast CancerOncology, 67
B. Liebersbach, R. Sanderson (1994)
Expression of syndecan-1 inhibits cell invasion into type I collagen.The Journal of biological chemistry, 269 31
M. Fujiya, J. Watari, T. Ashida, M. Honda, H. Tanabe, T. Fujiki, Y. Saitoh, Y. Kohgo (2001)
Reduced Expression of Syndecan‐1 Affects Metastatic Potential and Clinical Outcome in Patients with Colorectal CancerJapanese Journal of Cancer Research : Gann, 92
E. Hanekamp, S. Gielen, E. Smid-Koopman, Liesbeth Kühne, P. Ruiter, S. Chadha-Ajwani, A. Brinkmann, J. Grootegoed, C. Burger, F. Huikeshoven, L. Blok (2003)
Consequences of loss of progesterone receptor expression in development of invasive endometrial cancer.Clinical cancer research : an official journal of the American Association for Cancer Research, 9 11
Masaki Yanagishita, V. Hascall (1992)
Cell surface heparan sulfate proteoglycans.The Journal of biological chemistry, 267 14
H. Kresse, E. Schönherr (2001)
Proteoglycans of the extracellular matrix and growth controlJournal of Cellular Physiology, 189
J. Klatka (2002)
Syndecan-1 expression in laryngeal cancerEuropean Archives of Oto-Rhino-Laryngology, 259
A. Theocharis (2002)
Human colon adenocarcinoma is associated with specific post-translational modifications of versican and decorin.Biochimica et biophysica acta, 1588 2
J. Wiksten, J. Lundin, S. Nordling, M. Lundin, A. Kokkola, K. Boguslawski, C. Haglund (2001)
Epithelial and stromal syndecan‐1 expression as predictor of outcome in patients with gastric cancerInternational Journal of Cancer, 95
K. Voutilainen, M. Anttila, S. Sillanpää, R. Tammi, M. Tammi, S. Saarikoski, V. Kosma (2003)
Versican in epithelial ovarian cancer: Relation to hyaluronan, clinicopathologic factors and prognosisInternational Journal of Cancer, 107
M. Máthé, Z. Suba, Z. Németh, Péter Tátrai, T. Füle, G. Borgulya, J. Barabás, I. Kovalszky (2006)
Stromal syndecan-1 expression is an adverse prognostic factor in oral carcinomas.Oral oncology, 42 5
S. Skandalis, A. Theocharis, D. Theocharis, T. Papadas, D. Vynios, N. Papageorgakopoulou (2004)
Matrix proteoglycans are markedly affected in advanced laryngeal squamous cell carcinoma.Biochimica et biophysica acta, 1689 2
M. Takeichi (1991)
Cadherin cell adhesion receptors as a morphogenetic regulator.Science, 251 5000
P. Inki, F. Stenbäck, L. Talve, M. Jalkanen (1991)
Immunohistochemical localization of syndecan in mouse skin tumors induced by UV irradiation. Loss of expression associated with malignant transformation.The American journal of pathology, 139 6
A. Sakko, C. Ricciardelli, K. Mayne, W. Tilley, R. LeBaron, D. Horsfall (2001)
Versican accumulation in human prostatic fibroblast cultures is enhanced by prostate cancer cell-derived transforming growth factor beta1.Cancer research, 61 3
M. Bernfield, M. Götte, P. Park, O. Reizes, M. Fitzgerald, J. Lincecum, M. Zako (1999)
Functions of cell surface heparan sulfate proteoglycans.Annual review of biochemistry, 68
(1999)
Cell adhesion and proliferation mediated through the G 1 domain of versican
M. Pukkila, Ari Kosunen, K. Ropponen, J. Virtaniemi, J. Kellokoski, E. Kumpulainen, R. Pirinen, J. Nuutinen, R. Johansson, V. Kosma (2006)
High stromal versican expression predicts unfavourable outcome in oral squamous cell carcinomaJournal of Clinical Pathology, 60
J. Kodama, Hasengaowa, T. Kusumoto, N. Seki, T. Matsuo, K. Nakamura, A. Hongo, Y. Hiramatsu (2007)
Versican expression in human cervical cancer.European journal of cancer, 43 9
S. Kumar-Singh, W. Jacobs, K. Dhaene, B. Weyn, J. Bogers, J. Weyler, E. Marck (1998)
Syndecan‐1 expression in malignant mesothelioma: correlation with cell differentiation, WT1 expression, and clinical outcomeThe Journal of Pathology, 186
S. Suwiwat, C. Ricciardelli, R. Tammi, M. Tammi, P. Auvinen, V. Kosma, R. LeBaron, W. Raymond, W. Tilley, D. Horsfall (2004)
Expression of Extracellular Matrix Components Versican, Chondroitin Sulfate, Tenascin, and Hyaluronan, and Their Association with Disease Outcome in Node-Negative Breast CancerClinical Cancer Research, 10
(1995)
Expression of PGM ( V 3 ) , an alternatively spliced form of PGM without a chondroitin sulfate attachment in region in mouse and human tissues
T. Maeda, C. Alexander, A. Friedl (2004)
Induction of Syndecan-1 Expression in Stromal Fibroblasts Promotes Proliferation of Human Breast Cancer CellsCancer Research, 64
K. Ito, T. Shinomura, M. Zako, M. Ujita, K. Kimata (1995)
Multiple Forms of Mouse PG-M, a Large Chondroitin Sulfate Proteoglycan Generated by Alternative Splicing (*)The Journal of Biological Chemistry, 270
Proteoglycans are ubiquitous components of the extracellular matrix and cell surface, and may mediate tumor progression and metastasis. The aim of this study was to evaluate the expression of syndecan-1 and versican in epithelial ovarian cancer. We immunohistochemically evaluated the expression of syndecan-1 and versican in 111 patients with epithelial ovarian cancer, and analyzed the correlation of this expression with various observed clinicopathological features, including patient outcome. There is a significant correlation between primary and metastatic sites with respect to syndecan-1 and versican expression. Epithelial syndecan-1 expression was significantly lower in patients with advanced disease. Epithelial versican expression was significantly higher in patients with early disease, especially in clear cell adenocarcinoma patients. Stromal syndecan-1 and versican expression was significantly higher in patients with advanced disease. Multivariate analysis showed that negative epithelial syndecan-1 expression was an independent prognostic factor for progression-free survival. Stromal syndecan-1 and versican co-expression was of borderline significance for progression-free and overall survival. Loss of epithelial syndecan-1 expression and induction of stromal syndecan-1 and versican expression may be associated with tumor progression in epithelial ovarian cancer. Syndecan-1 and versican expression status can serve as an indicator of prognosis in patients with epithelial ovarian cancer.
Oncology Reports – Spandidos Publications
Published: Apr 1, 2010
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.