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Clinical implication of the preoperative GSA index in 99mTc-GSA scintigraphy in hepatitis C virus-related hepatocellular carcinoma

Clinical implication of the preoperative GSA index in 99mTc-GSA scintigraphy in hepatitis C... We aimed to examine the relationship between the preoperative GSA index (uptake ratio of the liver to the liver plus heart at 15 min (LHL15) to uptake ratio of the heart at 15 min to that at 3 min (HH15) ratio) calculated from 99mTc‑labeled diethylene triamine pentaacetate-galactosyl human serum albumin (99mTc-GSA) scintigraphy and background liver fibrosis and to investigate whether the GSA index can be a useful predictor in hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) patients treated with surgical resection (SR). A total of 213 HCV-related HCC patients were analyzed. Receiver operating characteristic (ROC) curve analysis was performed for calculating the area under the ROC (AUROC) for nine noninvasive parameters including GSA index, indocyanine green retention at 15 min, aspartate aminotransferase (AST) to platelet ratio index, FIB-4 index, AST to alanine aminotransferase ratio, serum albumin, total bilirubin, platelet count and prothrombin time for cirrhosis. We also examined predictive factors associated with overall survival (OS) and recurrence-free survival (RFS) after SR in univariate and multivariate analyses. There were 153 males and 60 females with the mean age of 69.9 years. The median observation periods were 2.8 years. The mean maximum tumor size was 4.1 cm. HH15 ranged from 0.452 to 0.897. LHL15 ranged from 0.669 to 0.982. The mean value of the GSA index was 1.41. Among the nine parameters, the GSA index yielded the highest AUROC for cirrhosis with a level of 0.786 at an optimal cut-off value of 1.37 (sensitivity, 65.9%; specificity, 79.0%). In multivariate analyses, the GSA index was an independent predictor (P<0.001) linked to RFS and it had a marginal significance in terms of OS (P=0.074). In conclusion, the preoperative GSA index can be a useful predictor in HCV-related HCC patients treated with SR. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Oncology Reports Spandidos Publications

Clinical implication of the preoperative GSA index in 99mTc-GSA scintigraphy in hepatitis C virus-related hepatocellular carcinoma

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Publisher
Spandidos Publications
Copyright
Copyright © Spandidos Publications
ISSN
1021-335X
eISSN
1791-2431
DOI
10.3892/or.2014.3691
pmid
25528990
Publisher site
See Article on Publisher Site

Abstract

We aimed to examine the relationship between the preoperative GSA index (uptake ratio of the liver to the liver plus heart at 15 min (LHL15) to uptake ratio of the heart at 15 min to that at 3 min (HH15) ratio) calculated from 99mTc‑labeled diethylene triamine pentaacetate-galactosyl human serum albumin (99mTc-GSA) scintigraphy and background liver fibrosis and to investigate whether the GSA index can be a useful predictor in hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) patients treated with surgical resection (SR). A total of 213 HCV-related HCC patients were analyzed. Receiver operating characteristic (ROC) curve analysis was performed for calculating the area under the ROC (AUROC) for nine noninvasive parameters including GSA index, indocyanine green retention at 15 min, aspartate aminotransferase (AST) to platelet ratio index, FIB-4 index, AST to alanine aminotransferase ratio, serum albumin, total bilirubin, platelet count and prothrombin time for cirrhosis. We also examined predictive factors associated with overall survival (OS) and recurrence-free survival (RFS) after SR in univariate and multivariate analyses. There were 153 males and 60 females with the mean age of 69.9 years. The median observation periods were 2.8 years. The mean maximum tumor size was 4.1 cm. HH15 ranged from 0.452 to 0.897. LHL15 ranged from 0.669 to 0.982. The mean value of the GSA index was 1.41. Among the nine parameters, the GSA index yielded the highest AUROC for cirrhosis with a level of 0.786 at an optimal cut-off value of 1.37 (sensitivity, 65.9%; specificity, 79.0%). In multivariate analyses, the GSA index was an independent predictor (P<0.001) linked to RFS and it had a marginal significance in terms of OS (P=0.074). In conclusion, the preoperative GSA index can be a useful predictor in HCV-related HCC patients treated with SR.

Journal

Oncology Reports – Spandidos Publications

Published: Mar 1, 2015

References

  • Epidemiology of viral hepatitis and hepatocellular carcinoma
    El-Serag
  • Management of HCC
    de Lope
  • Treatment for hepatocellular carcinoma in Japan over the last three decades: our experience and published work review
    Osaki
  • A prospective, randomized, controlled trial of preoperative transarterial chemoembolization for resectable large hepatocellular carcinoma
    Zhou
  • Transcatheter arterial infusion chemotherapy prior to radiofrequency thermal ablation for single hepatocellular carcinoma reduces the risk of intrahepatic distant recurrence
    Nishikawa
  • Receptor index via hepatic asialoglycoprotein receptor imaging: correlation with chronic hepatocellular damage
    Kudo
  • Hepatic lobar differences in progression of chronic liver disease: correlation of asialoglycoprotein scintigraphy and hepatic functional reserve
    Matsuzaki
  • Usefulness of Tc-99m-GSA scintigraphy for liver surgery
    Kaibori
  • Improved reproducibility of simple quantitative indices from 99mTc-GSA liver functional imaging
    Ogasawara
  • Area between the hepatic and heart curves of 99mTc-galactosyl-human serum albumin scintigraphy represents liver function and disease progression for preoperative evaluation in hepatocellular carcinoma patients
    Harada
  • Measurement of liver volume and hepatic functional reserve as a guide to decision-making in resectional surgery for hepatic tumors
    Kubota
  • Indocyanine green clearance test (using spectrophotometry) and its correlation with model for end stage liver disease (MELD) score in Indian patients with cirrhosis of liver
    Gupta
  • Graft size, donor age, and patient status are the indicators of early graft function after living donor liver transplantation
    Yoshizumi
  • Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
    Alberti
  • Preoperative assessment of hepatic function: utility of a new convenient two-compartment model analysis using galactosyl human serum albumin scintigraphy
    Kinoshita
  • A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C
    Wai
  • Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
    Sterling
  • Management of hepatocellular carcinoma
    Bruix
  • The general rules for the clinical and pathological study of primary liver cancer. Liver Cancer Study Group of Japan
  • A comparison of the surgical outcomes among patients with HBV-positive, HCV-positive, and non-B non-C hepatocellular carcinoma: a nationwide study of 11,950 patients
    Utsunomiya
  • Preoperative aspartate aminotransferase to platelet ratio is an independent prognostic factor for hepatitis B-induced hepatocellular carcinoma after hepatic resection
    Shen
  • Surgical treatment for HCC - special reference to anatomical resection
    Makuuchi
  • Risk factors of post-operative recurrence and adequate surgical approach to improve long-term outcomes of hepatocellular carcinoma
    Shindoh
  • Simple noninvasive systems predict long-term outcomes of patients with nonalcoholic fatty liver disease
    Angulo
  • Performance of the aspartate aminotransferase-to-platelet ratio index for the staging of hepatitis C-related fibrosis: an updated meta-analysis
    Lin
  • Systematic review: non-invasive methods of fibrosis analysis in chronic hepatitis C
    Smith
  • Prospective comparison of noninvasive fibrosis assessment to predict advanced fibrosis or cirrhosis in Asian patients with hepatitis C
    Joo
  • Evolution of noninvasive tests of liver fibrosis is associated with prognosis in patients with chronic hepatitis C
    Vergniol
  • Comparison of diagnostic accuracy of APRI and FIB-4 for detecting liver fibrosis in adult patients with chronic hepatitis B virus infection: a systemic review and meta-analysis
    Xiao
  • Role of liver biopsy in nonalcoholic fatty liver disease
    Nalbantoglu
  • Noninvasive evaluation of NAFLD
    Castera
  • Transient elastography and other noninvasive tests to assess hepatic fibrosis in patients with viral hepatitis
    Castera
  • Microvascular invasion is a better predictor of tumor recurrence and overall survival following surgical resection for hepatocellular carcinoma compared to the Milan criteria
    Lim
  • Applicability of staging systems for patients with hepatocellular carcinoma is dependent on treatment method - analysis of 2,010 Taiwanese patients
    Chen