Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

CLC-3 channels in cancer (Review)

CLC-3 channels in cancer (Review) Ion channels are involved in regulating cell proliferation and apoptosis (programed cell death). Since increased cellular proliferation and inhibition of apoptosis are characteristic features of tumorigenesis, targeting ion channels is a promising strategy for treating cancer. CLC-3 is a member of the voltage-gated chloride channel superfamily and is expressed in many cancer cells. In the plasma membrane, CLC-3 functions as a chloride channel and is associated with cell proliferation and apoptosis. CLC-3 is also located in intracellular compartments, contributing to their acidity, which increases sequestration of drugs and leads to chemotherapy drug resistance. In this review, we summarize the recent findings concerning the involvement of CLC-3 in cancer and explore its potential in cancer therapy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Oncology Reports Spandidos Publications

CLC-3 channels in cancer (Review)

Download PDF
8 pages

Loading next page...
 
/lp/spandidos-publications/clc-3-channels-in-cancer-review-qp66gGn2CR

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Spandidos Publications
Copyright
Copyright © Spandidos Publications
ISSN
1021-335X
eISSN
1791-2431
DOI
10.3892/or.2014.3615
pmid
25421907
Publisher site
See Article on Publisher Site

Abstract

Ion channels are involved in regulating cell proliferation and apoptosis (programed cell death). Since increased cellular proliferation and inhibition of apoptosis are characteristic features of tumorigenesis, targeting ion channels is a promising strategy for treating cancer. CLC-3 is a member of the voltage-gated chloride channel superfamily and is expressed in many cancer cells. In the plasma membrane, CLC-3 functions as a chloride channel and is associated with cell proliferation and apoptosis. CLC-3 is also located in intracellular compartments, contributing to their acidity, which increases sequestration of drugs and leads to chemotherapy drug resistance. In this review, we summarize the recent findings concerning the involvement of CLC-3 in cancer and explore its potential in cancer therapy.

Journal

Oncology Reports – Spandidos Publications

Published: Feb 1, 2015

References

  • Cardiac channelopathies
    Marban
  • Skeletal muscle channelopathies: new insights into the periodic paralyses and nondystrophic myotonias
    Platt
  • Inherited neuronal ion channelopathies: new windows on complex neurological diseases
    Catterall
  • Chloride channelopathies
    Planells-Cases
  • Ion channelopathies in endocrinology: recent genetic findings and pathophysiological insights
    Rolim
  • Ion channels and transporters in cancer. 5 Ion channels in control of cancer and cell apoptosis
    Lehen’kyi
  • Ion channels and cancer
    Kunzelmann
  • Ion channels and transporters in the development of drug resistance in cancer cells
    Hoffmann
  • Ion channels in cancer: future perspectives and clinical potential
    Lang
  • Ion channels as targets for cancer therapy
    Li
  • Targeting ion channels in cancer: a novel frontier in antineoplastic therapy
    Arcangeli
  • Targeting ion channels for new strategies in cancer diagnosis and therapy
    Conti
  • Ion channels and apoptosis in cancer
    Bortner
  • The role of ion channels and transporters in cell proliferation and cancer
    Becchetti
  • Ion channels in death and differentiation of prostate cancer cells
    Prevarskaya
  • Ion channels in cell proliferation and apoptotic cell death
    Lang
  • Cell volume regulatory ion channels in cell proliferation and cell death
    Lang
  • Potassium channels in cell cycle and cell proliferation
    Urrego
  • Bioelectric controls of cell proliferation: ion channels, membrane voltage and the cell cycle
    Blackiston
  • Expression and activity of potassium ion channels in human prostate cancer
    Abdul
  • Volume-activated Cl− channels
    Nilius
  • A novel function of BCL-2 overexpression in regulatory volume decrease. Enhancing swelling-activated Ca(2+) entry and Cl(−) channel activity
    Shen
  • The CLC-3 chloride channels in cardiovascular disease
    Duan
  • Suppression of CLC-3 channel expression reduces migration of nasopharyngeal carcinoma cells
    Mao
  • Bcl-2-dependent modulation of swelling-activated Cl− current and CLC-3 expression in human prostate cancer epithelial cells
    Lemonnier
  • CLC3 is a critical regulator of the cell cycle in normal and malignant glial cells
    Habela
  • Functional effects of novel anti-CLC-3 antibodies on native volume-sensitive osmolyte and anion channels in cardiac and smooth muscle cells
    Wang
  • Inhibition of swelling-activated Cl− currents by functional anti-CLC-3 antibody in native bovine non-pigmented ciliary epithelial cells
    Do
  • Regulation of intracellular CI− concentration through volume-regulated CLC-3 chloride channels in A10 vascular smooth muscle cells
    Zhou
  • Chloride channels: often enigmatic, rarely predictable
    Duran
  • CLC-3 is an intracellular chloride/proton exchanger with large voltage-dependent nonlinear capacitance
    Guzman
  • Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins
    Scheel
  • Chloride/proton antiporter activity of mammalian CLC proteins CLC-4 and CLC-5
    Picollo
  • CLC-3 chloride channels facilitate endosomal acidification and chloride accumulation
    Hara-Chikuma
  • Subcellular localization and activity of multidrug resistance proteins
    Rajagopal
  • CLC-3 expression enhances etoposide resistance by increasing acidification of the late endocytic compartment
    Weylandt
  • Suppression of chloride channel 3 expression facilitates sensitivity of human glioma U251 cells to cisplatin through concomitant inhibition of Akt and autophagy
    Su
  • 5-Nitro-2-(3-phenylpropylamino) benzoic acid induced drug resistance to cisplatin in human erythroleukemia cell lines
    Xu
  • CLC-3 chloride channels are essential for cell proliferation and cell cycle progression in nasopharyngeal carcinoma cells
    Xu
  • The CLC-3 chloride channel protein is a downstream target of cyclin D1 in nasopharyngeal carcinoma cells
    Zhang
  • An unexpected role for ion channels in brain tumor metastasis
    Sontheimer
  • CLC-3 is a candidate of the channel proteins mediating acid-activated chloride currents in nasopharyngeal carcinoma cells
    Wang
  • Effects of volume-activated chloride channels on the invasion and migration of human endometrial cancer cells
    Li
  • Malignant gliomas in adults
    Wen
  • Invasion of human glioma cells is regulated by multiple chloride channels including CLC-3
    Lui
  • Expression of voltage-gated chloride channels in human glioma cells
    Olsen
  • Calcium dependence of purinergic subtype P2Y1 receptor modulation of C6 glioma cell migration
    Jantaratnotai
  • Bradykinin promotes the chemotactic invasion of primary brain tumors
    Montana
  • Molecular interaction and functional regulation of CLC-3 by Ca2+/calmodulin-dependent protein kinase II (CaMKII) in human malignant glioma
    Cuddapah
  • Regulation of human CLC-3 channels by multifunctional Ca2+/calmodulin-dependent protein kinase
    Huang
  • Bradykinin-induced chemotaxis of human gliomas requires the activation of KCa3.1 and CLC-3
    Cuddapah
  • Cytoplasmic volume condensation is an integral part of mitosis
    Habela
  • Kinase activation of CLC-3 accelerates cytoplasmic condensation during mitotic cell rounding
    Cuddapah
  • CLC-3 expression in the cell cycle of nasopharyngeal carcinoma cells
    Wang
  • CLC-3 siRNA inhibits regulatory volume decrease in nasopharyngeal carcinoma cells
    Ye
  • CLC-3 Is A main component of background chloride channels activated under isotonic conditions by autocrine ATP in nasopharyngeal varcinoma cells
    Yang
  • Differential expression and roles of volume-activated chloride channels in control of growth of normal and cancerous nasopharyngeal epithelial cells
    Zhu
  • pH and drug resistance. II Turnover of acidic vesicles and resistance to weakly basic chemotherapeutic drugs
    Raghunand
  • Physiology of cell volume regulation in vertebrates
    Hoffmann
  • Mechanisms and significance of cell volume regulation
    Lang
  • Cell volume regulation and swelling-activated chloride channels
    Sardini
  • Blocking swelling-activated chloride current inhibits mouse liver cell proliferation
    Wondergem
  • Inhibition by mibefradil, a novel calcium channel antagonist, of Ca(2+)- and volume-activated Cl− channels in macrovascular endothelial cells
    Nilius
  • Swelling-activated Cl− currents and intracellular CLC-3 are involved in proliferation of human pulmonary artery smooth muscle cells
    Liang
  • Differential expression of volume-regulated anion channels during cell cycle progression of human cervical cancer cells
    Shen
  • Molecular identification of a volume-regulated chloride channel
    Duan
  • Disruption of CLC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus
    Stobrawa
  • Altered properties of volume-sensitive osmolyte and anion channels (VSOACs) and membrane protein expression in cardiac and smooth muscle myocytes from Clcn3−/− mice
    Yamamoto-Mizuma
  • Cardiac-specific, inducible CLC-3 gene deletion eliminates native volume-sensitive chloride channels and produces myocardial hypertrophy in adult mice
    Xiong
  • Deficiency in CLC-3 chloride channels prevents rat aortic smooth muscle cell proliferation
    Wang
  • Silence of CLC-3 chloride channel inhibits cell proliferation and the cell cycle via G/S phase arrest in rat basilar arterial smooth muscle cells
    Tang
  • Cell size-dependent and independent proliferation of rodent neuroblastoma x glioma cells
    Rouzaire-Dubois
  • The influence of cell volume changes on tumour cell proliferation
    Dubois
  • Osmotic cell swelling-induced ATP release mediates the activation of extracellular signal-regulated protein kinase (Erk)-1/2 but not the activation of osmo-sensitive anion channels
    Van der Wijk
  • Tyrosine kinase activation is an immediate and essential step in hypotonic cell swelling-induced ERK activation and c-fos gene expression in cardiac myocytes
    Sadoshima
  • Interplay between MEK-ERK signaling, cyclin D1 and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons
    Modi
  • ERK crosstalks with 4EBP1 to activate cyclin D1 translation during quinol-thioether-induced tuberous sclerosis renal cell carcinoma
    Cohen
  • The importance of ERK activity in the regulation of cyclin D1 levels and DNA synthesis in human cultured airway smooth muscle
    Ravenhall
  • A primary role for K+ and Na+ efflux in the activation of apoptosis
    Bortner
  • Cellular function and control of volume-regulated anion channels
    Eggermont
  • Cell volume regulation in epithelial physiology and cancer
    Pedersen
  • Swelling-activated ion channels: functional regulation in cell-swelling, proliferation and apoptosis
    Stutzin
  • Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis
    Maeno
  • Volume-sensitive chloride channels involved in apoptotic volume decrease and cell death
    Okada
  • CLC-3 chloride channel prevents apoptosis induced by hydrogen peroxide in basilar artery smooth muscle cells through mitochondria dependent pathway
    Qian
  • Involvement of chloride channels in TGF-beta1-induced apoptosis of human bronchial epithelial cells
    Cheng
  • CLC-3 chloride channel prevents apoptosis induced by thapsigargin in PC12 cells
    Zhang
  • The CLC-3 chloride channel associated with microtubules is a target of paclitaxel in its induced-apoptosis
    Zhang
  • Discovery of bufadienolides as a novel class of CLC-3 chloride channel activators with antitumor activities
    Liu
  • Up-regulation of Bcl-2 is required for the progression of prostate cancer cells from an androgen-dependent to an androgen-independent growth stage
    Lin
  • TMEM16A confers receptor-activated calcium-dependent chloride conductance
    Yang
  • Fundamental role of CLC-3 in volume-sensitive Cl− channel function and cell volume regulation in AGS cells
    Jin
  • Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumor activity
    Gomez-Varela
  • Chloride channel inhibition by the venom of the scorpion Leiurus quinquestriatus
    DeBin
  • Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2
    Deshane
  • The impact of a chlorotoxin-modified liposome system on receptor MMP-2 and the receptor-associated protein CLC-3
    Qin
  • Phase I single-dose study of intracavitary-administered iodine-131-TM-601 in adults with recurrent high-grade glioma
    Mamelak
  • Cardiac glycosides as novel cancer therapeutic agents
    Newman
  • In vitro cardiotoxicity and mechanism of action of the Egyptian green toad Bufo viridis skin secretions
    Abdel-Rahman
  • Cardioactive steroid poisoning: a comparison of plant- and animal-derived compounds
    Barrueto
  • Improved antitumor efficacy and reduced toxicity of liposomes containing bufadienolides
    Hu
  • CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis
    Yoshikawa