Access the full text.
Sign up today, get DeepDyve free for 14 days.
Fosko (2020)
Efficacy, rate of tumor response, and safety of a short course (12–24 weeks) of oral vismodegib in various histologic subtypes (infiltrative, nodular, and superficial) of high-risk or locally advanced basal cell carcinoma, in an open-label, prospective case series clinical trialJ Am Acad Dermatol, 82
Kasperczyk (2009)
Characterization of sonic hedgehog as a novel NF-kappaB target gene that promotes NF-kappaB-mediated apoptosis resistance and tumor growth in vivoFASEB J, 23
Sharma (2018)
Role of stem cell derived exosomes in tumor biologyInt J Cancer, 142
Bhat (2018)
Upstream Hedgehog signaling components are exported in exosomes of cervical cancer cell linesNanomedicine, 13
Ingham (2001)
Hedgehog signaling in animal development: Paradigms and principlesGenes Dev, 15
Raghavan (2020)
Carcinoma-associated mesenchymal stem cells promote chemoresistance in ovarian cancer stem cells via PDGF signalingCancers, 12
Gradilla (2014)
Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretionNat Commun, 5
Matsumoto (2004)
Exosomes secreted from monocyte-derived dendritic cells support in vitro naïve CD4+ T cell survival through NF-(kappa)B activationCell Immunol, 231
Maroufy (2020)
Gene expression dynamic analysis reveals co-activation of sonic hedgehog and epidermal growth factor followed by dynamic silencingOncotarget, 11
Kinzler (1987)
Identification of an amplified, highly expressed gene in a human gliomaScience, 236
Mignot (2006)
Prospects for exosomes in immunotherapy of cancerJ Cell Mol Med, 10
Chapouly (2019)
Role of hedgehog signaling in vasculature development, differentiation, and maintenanceInt J Mol Sci, 20
Ichimiya (2021)
Contribution of pre-existing neoantigen-specific T cells to durable complete responses after tumor-pulsed dendritic cell vaccine plus nivolumab therapy in a patient with metastatic salivary duct carcinomaImmunol Invest
Onishi (2013)
The Hedgehog inhibitor cyclopamine impairs the benefits of immunotherapy with activated T and NK lymphocytes derived from patients with advanced cancerCancer Immunol Immunother, 62
Nakashima (2006)
Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancerCancer Res, 66
Tanaka (2009)
The Hedgehog signaling pathway plays an essential role in maintaining the CD44+CD24-/low subpopulation and the side population of breast cancer cellsAnticancer Res, 29
Mühlbauer (2006)
PD-L1 is induced hepatocytes by viral infection and interferon-alpha and -gamma and mediates T cell apoptosisJ Hepatol, 45
Le (2020)
Bevacizumab augments the antitumor efficacy of infigratinib in hepatocellular carcinomaInt J Mol Sci, 21
Onishi (2018)
RBPJ and MAML3: Potential therapeutic targets for small cell lung cancerAnticancer Res, 38
Dijkgraaf (2011)
Small molecule inhibition of GDC-0499 refractory smoothened mutants and downstream mechanisms of drug resistanceCancer Res, 71
Lei (2013)
Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent mannerMol Cancer, 12
Moriyama (2018)
Notch signaling enhances stemness by regulating metabolic pathways through modifying p53, NF-κB, and HIF-1αStem Cells Dev, 27
Morifuji (2014)
Reoxygenation from chronic hypoxia promotes metastatic processes in pancreatic cancer through the Hedgehog signalingCancer Sci, 105
Winning (2016)
Dendritic cells under hypoxia: How oxygen shortage affects the linkage between innate and adaptive immunityJ Immunol Res, 2016
Cheng (2009)
Role of Hedgehog signaling pathway in proliferation and invasiveness of hepatocellular carcinoma cellsInt J Oncol, 34
Qi (2017)
Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth through hedgehog signaling pathwayCell Physiol Biochem, 42
Bausch (2020)
Hedgehog signaling promotes angiogenesis directly and indirectly in pancreatic cancerAngiogenesis, 23
Bosco (2011)
Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: Identification of TREM-1 as a novel hypoxic marker in vitro and in vivoBlood, 117
Zhu (2017)
Soluble PD-1 and PD-L1: Predictive and prognostic significance in cancerOncotarget, 8
Katagiri (2018)
HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating expression and secretion of sonic hedgehogOncotarget, 9
Westendorf (2017)
Hypoxia enhances immunosuppression by inhibiting CD4+ Effector T cell function and promoting treg activityCell Physiol Biochem, 41
Gargiulo (2013)
In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasisCancer Cell, 23
Onishi (2016)
Hedgehog signaling regulates PDL-1 expression in cancer cells to induce anti-tumor activity by activated lymphocytesCell Immunol, 310
Petty (2019)
Hedgehog signaling promotes tumor-associated macrophage polarization to suppress intratumoral CD8+ T cell recruitmentClin Invest, 129
Hsieh (2011)
Hedgehog/GLI1 regulates IGF dependent malignant behaviors in glioma stem cellsJ Cell Physiol, 226
Burke (2003)
Hypoxia-induced gene expression in human macrophages: Implications for ischemic tissues and hypoxia-regulated gene therapyAm J Pathol, 163
Yamasaki (2020)
Hypoxia and pancreatic ductal adenocarcinomaCancer Lett, 484
Meng (2017)
Curcumin increases efficiency of γ-irradiation in gliomas by inhibiting Hedgehog signaling pathwayCell Cycle, 16
Onishi (2011)
Hedgehog signaling pathway as a therapeutic target in various types of cancerCancer Sci, 102
Thayer (2003)
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesisNature, 425
Chakrabarti (2018)
Hedgehog signaling induces PD-L1 expression and tumor cell proliferation in gastric cancerOncotarget, 9
Cao (2016)
Curcumin inhibits hypoxia-induced epithelial-mesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathwayOncol Rep, 35
Steele (2021)
Inhibition of hedgehog signaling alters fibroblast composition in pancreatic cancerClin Cancer Res, 27
Onishi (2013)
The Hedgehog inhibitor suppresses the function of monocyte-derived dendritic cells from patients with advanced cancer under hypoxiaBiochem Biophys Res Commun, 436
Pierobon (2013)
Chronic hypoxia reprograms human immature dendritic cells by inducing a proinflammatory phenotype and TREM-1 expressionEur J Immunol, 43
Bai (2020)
Notch signaling pathway and endocrine resistance in breast cancerFront Pharmacol, 11
Zhou (2020)
Exosomal PD-L1: New insights into tumor immune escape mechanisms and therapeutic strategiesFront Cell Dev Biol, 8
Bhuria (2019)
Hypoxia induced Sonic Hedgehog signaling regulates cancer stemness, epithelial-to-mesenchymal transition and invasion in cholangiocarcinomaExp Cell Res, 385
Nakayama (2020)
NFκB and TGFβ contribute to the expression of PTPN3 in activated human lymphocytesCell Immunol, 358
Zurawel (2000)
Analysis of PTCH/SMO/SHH pathway genes in medulloblastomaGenes Chromosomes Cancer, 27
Gailani (1997)
Developmental genes and cancer: Role of patched in basal cell carcinoma of the skinJ Natl Cancer Inst, 89
Albini (2011)
Cancer stem cells and the tumor microenvironment: Soloists or choral singersCurr Pharm Biotechnol, 12
Tai (2018)
FGFRL1 promotes ovarian cancer progression by crosstalk with hedgehog signalingJ Immunol Res, 2018
Sureshbabu (2020)
Hypoxia regulates the differentiation and anti-tumor effector functions of γδT cells in oral cancerClin Exp Immunol, 201
Dennler (2007)
Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivoCancer Res, 67
Schartz (2002)
From the antigen-presenting cell to the antigen-presenting vesicle: The exosomesCurr Opin Mol Ther, 4
Yamasaki (2009)
Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of ShhCancer Immunol Immunother, 59
Criscimanna (2013)
PanIN-specific regulation of Wnt signaling by HIF2α during early pancreatic tumorigenesisCancer Res, 73
Hockel (2001)
Association between host tissue vascularity and the prognostically relevant tumor vascularity in human cervical cancerInt J Oncol, 19
Liu (2017)
Hypoxia accelerates aggressiveness of hepatocellular carcinoma cells involving oxidative stress, epithelial-mesenchymal transition and non-canonical hedgehog signalingCell Physiol Biochem, 44
Balkwill (2012)
The tumor microenvironment at a glanceJ Cell Sci, 125
Fu (2015)
Hypoxia-inducible factor-1α protects cervical carcinoma cells from apoptosis induced by radiation via modulation of vascular endothelial growth factor and p53 under hypoxiaMed Sci Monit, 21
Zhang (2017)
Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancerMol Cancer, 16
Blank (2007)
Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: An update on implications for chronic infections and tumor evasionCancer Immunol Immunother, 56
Ader (2006)
Transcriptional profiling implicates TGFbeta/BMP and Notch signaling pathways in ductular differentiation of fetal murine hepatoblastsMech Dev, 123
Fang (2020)
Hydroxytyosol inhibits apoptosis in ischemia/reperfusion-induced acute kidney injury via activating sonic edgehog signaling pathwayEur Rev Med Pharmacol Sci, 24
Cubillos-Zapata (2017)
Hypoxia-induced PD-L1/PD-1 crosstalk impairs T-cell function in sleep apnoeaEur Respir J, 50
Xue (2015)
Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitisNat Commun, 6
Ueshima (2019)
Macrophage-secreted TGF-β 1 contributes to fibroblast activation and ureteral stricture after ablation injuryAm J Physiol Renol Physiol, 317
Onishi (2011)
Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancerCancer Sci, 102
Liu (2021)
Hypoxia induces overexpression of CCL28 to recruit Treg cells to enhance angiogenesis in lung adenocarcinomaJ Environ Pathol Toxicol Oncol, 40
Zhao (2020)
Exosomal Sonic Hedgehog derived from cancer-associated fibroblasts promotes proliferation and migration of esophageal squamous cell carcinomaCancer Med, 9
Qualtrough (2004)
Hedgehog signalling in colorectal tumour cells: Induction of apoptosis with cyclopamine treatmentInt J Cancer, 110
Wada (2010)
Surface-bound TGF-beta1 on effusion-derived exosomes participates in maintenance of number and suppressive function of regulatory T-cells in malignant effusionsAnticancer Res, 30
Yauch (2009)
Smoothened mutation confere resistance to a Hedgehog pathway inhibitor in medulloblastomaScience, 326
Milla (2012)
Sonic hedgehog in cancer stem cells: A novel link with autophagyBiol Res, 45
Sun (2020)
Hypoxia-mediated cancer stem cell resistance and targeted therapy. BiomedPharmacother, 130
Javelaud (2012)
Crosstalk between TGF-β and hedgehog signaling in cancerFEBS Lett, 586
Deep (2015)
Hypoxia-induced signaling promotes prostate cancer progression: Exosomes role as messenger of hypoxic response in tumor microenvironmentCrit Rev Oncog, 20
Cai (2019)
Targeting the cross-talk between the hedgehog and NF-κB signaling pathways in multiple myelomaLeuk Lymphoma, 60
Zhu (2017)
Hedgehog signaling contributes to basic fibroblast growth factor-regulated fibroblast migrationExp Cell Res, 355
Stewart (2003)
Expression of the developmental sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytesJ Pathol, 199
Wei (2019)
Oroxylin A increases the sensitivity of temozolomide on glioma cells by hypoxia-inducible factor 1α/hedgehog pathway under hypoxia xiaJ Cell Physiol, 234
Fingleton (2001)
Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosisNeoplasia, 3
Zhang (2018)
Sonic hedgehog signaling regulates hypoxia/reoxygenation-induced H9C2 myocardial cell apoptosisExp Ther Med, 16
Tostar (2006)
Deregulation of the hedgehog signalling pathway: A possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma developmentJ Pathol, 208
Onishi (2016)
Hypoxia but not normoxia promotes Smoothened transcription through upregulation of RBPJ and Mastermind-like 3 in pancreatic cancerCancer Lett, 371
Pinter (2013)
Hedgehog inhibition reduces angiogenesis by downregulation of tumoral VEGF-A expression in hepatocellular carcinomaUnited European Gastroenterol J, 1
Gupta (2014)
Acidosis promotes invasiveness of vreast cancer cells through ROS-AKT-NF-kB pathwayOncotarget, 5
Cao (2017)
Gultamic pyruvate transaminase GPT2 promotes tumorigenesis of breast cancer cells by activating sonic hedgehog signalingTheranostics, 7
Shang (2018)
Blocking NOTCH pathway can enhance the effect of EGFR inhibitor through targeting CD133+ endometrial cancer cellsCancer Biol Ther, 19
Pandit (2018)
Enrichment of cancer stem cells via β-catenin contributing to the tumorigenesis of hepatocellular carcinomaBMC Cancer, 18
Watkins (2003)
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancerNature, 422
Fan (2004)
Hedgehog signaling promotes prostate xenograft tumor growthEndocrinology, 145
Xu (2020)
Resveratrol counteracts hypoxia-induced gastric cancer invasion and EMT through hedgehog pathway suppressionAnticancer Agents Med Chem, 20
Oyama (2020)
Patched 1-interacting peptide represses fibrosis in pancreatic cancer to augment the effectiveness of immunotherapyJ Immunother, 43
Wu (2014)
Hypoxia promotes stem-like properties of laryngeal cancer cell lines by increasing the CD133+ stem cell fractionInt J Oncol, 44
Ma (2005)
Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomasCarcinogenesis, 26
Ogino (2012)
Inclusive estimation of complex antigen presentation functions of monocyte-derived dendritic cells differentiated under normoxia and hypoxia conditionsCancer Immunol Immunother, 61
Merchant (2017)
Hedgehog signaling links chronic inflammation to gastric cancer precursor lesionsCell Mol Gastroenterol Hepatol, 3
Eyrich (2019)
Reactive oxygen species signaling promotes hypoxia-inducible factor 1 α stabilization in sonic hedgehog-driven cerebellar progenitor cell proliferationMol Cell Biol, 39
D'Alessandris (2021)
PD-L1 expression is associated with tumor infiltrating lymphocytes that predict response to NACT in squamous cell cervical cancerVirchows Arch, 478
Chen (2007)
Hedgehog signal pathway is activated in ovarian carcinomas, correlating with cell proliferation: It's inhibition leads to growth suppression and apoptosisCancer Sci, 98
Castagnoli (2020)
Inhibition of the Wnt signalling pathway: An avenue to control breast cancer aggressivenessInt J Mol Sci, 21
Elia (2008)
Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profileJ Leukoc Biol, 84
Wang (2017)
Role of tumor microenvironment in tumorigenesisJ Cancer, 8
Noman (2014)
PD-L1 is a novel direct target of HIF-1α, and its blockade under ypoxia enhanced MDSC-mediated T cell activationJ Exp Med, 211
Li (2016)
Resveratrol inhibits hypoxia-driven ROS-induced invasive and migratory ability of pancreatic cancer cells via suppression of the hedgehog signaling pathwayOncol Rep, 35
Emami Nejad (2021)
The role of hypoxia in the tumor microenvironment and development of cancer stem cell: A novel approach to developing treatmentCancer Cell Int, 21
Wu (2013)
Autophagy and mammalian developmentBiochem Soc Trans, 41
Sarighieh (2020)
The inhibitory effect on hypoxia inducer (Hifs) as a regulatory factor in the growth of tumor cells in breast cancer stem-like cellsDrug Res, 70
De Jesus-Acosta (2020)
Phase 2 study of vismodegib, a hedgehog inhibitor, combined with gemcitabine and nab-paclitaxel in patients with untreated metastatic pancreatic adenocarcinomaBr J Cancer, 122
Ables (2011)
Not(ch) just development: Notch signalling in the adult brainNat Rev Neurosci, 12
Onishi (2014)
The Hedgehog signaling pathway as a new therapeutic target in pancreatic cancerWorld J Gastroenterol, 20
Zhu (2020)
Qingjie fuzheng granules regulates cancer cell proliferation, apoptosis and tumor angiogenesis in colorectal cancer xenograft mice via sonic hedgehog pathwayJ Gastrointest Oncl, 11
Low (2010)
Clinical experience with hedgehog pathway inhibitorsJ Clin Oncol, 28
Chiu (2016)
Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26Hepatology, 64
Zeng (2018)
Hedgehog signaling pathway and autophagy in cancerInt J Mol Sci, 19
Onishi (2004)
Monocyte-derived dendritic cells that capture dead tumor cells secrete IL-12 and TNF-alpha through IL-12/TNF-alpha/NF-kappaB autocrine loopCancer Immunol Immunother, 53
Zhang (2017)
Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosisBr J Pharmacol, 175
Yao (2014)
Sonic hedgehog mediates a novel pathway of PDGF-BB-dependent vessel maturationBlood, 123
Zhou (2020)
Novel interplay between sonic hedgehog and transforming growth factor-β1 in human nonalcoholic steatohepatitisAppl Immunohistochem Mol Morphol, 28
Yánez (2019)
Hedgehog signaling promotes T H 2 differentiation in naive human CD4 T cellsAllergy Clin Immunol, 144
Wang (2013)
Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cellsHepatology, 58
Rakhshandehroo (2022)
Molecular immune targeted imaging of tumor microenvironmentNanotheranostics, 6
Kroon (2001)
Hypoxia in combination with FGF-2 induces tube formation by human microvascular endothelial cells in a fibrin matrix: Involvement of at least two signal transduction pathwaysJ Cell Sci, 114
Gagné-Sansfaçon (2014)
Loss of Sonic hedgehog leads to alterations in intestinal secretory cell maturation and autophagyPLoS One, 9
Prasad (2017)
Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticalsCancer Lett, 387
de la Roche (2013)
Hedgehog signaling controls T cell killing at the immunological synapseScience, 342
Mondal (2018)
Nutritional stress reprograms dedifferention in glioblastoma multiforme driven by PTEN/Wnt/Hedgehog axis: A stochastic model of cancer stem cellsCell Death Discov, 4
Olive (2009)
Inhibition of hedgehog signaling enhances delivery of chemotherapy in mouse model of pancreatic cancerScience, 324
Yang (2020)
Curcumol attenuates liver sinusoidal endothelial cell angiogenesis via regulating Glis-PROX1-HIF-1 α in liver fibrosisCell Prolif, 53
Bailey (2008)
Sonic hedgehog promotes desmoplasia in pancreatic cancerClin Cancer Res, 14
Noman (2015)
Hypoxia: A key player in antitumor immune response. A review in the theme: Cellular responses to hypoxiaAm J Physiol Cell Physiol, 309
Omenetti (2008)
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humansJ Clin Invest, 118
Jiayuan (2020)
Gant61 ameliorates CCl4-induced liver fibrosis by inhibition of hedgehog signaling activityToxicol Appl Pharmcol, 387
Tian (2015)
Overexpression of hypoxia-inducible factor 1α induces migration and invasion through Notch signalingInt J Oncol, 47
Fan (2015)
A novel approach to overcome non-small-cell lung cancer: Co-inhibition of autophagy and Hedgehog pathwayAnn Oncol, 26
Spivak-Kroizman (2013)
Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancerCancer Res, 73
Recently, the cancer microenvironment (CME) has received significant attention. At the local site of the tumor, cancer progression is affected by secreted cytokines and conditions derived from the CME and stimulation by cancer‑induced cytokines in an autocrine manner. The CME is characterized by various types of conditions, such as hypoxia, inflammation stimulation, and angiogenesis, and contains various components, such as reactive oxygen species, cancer‑associated fibroblasts, infiltrated immune cells, exosomes, and cancer stem cells (CSCs). These conditions and components complicate the progression of cancer. The Hedgehog (HH) signaling pathway is a morphogenesis signaling pathway that is reactivated in some cancers. In these cancers, reactivated HH signaling is involved in the induction of the malignant phenotype. HH signaling is also activated under hypoxic conditions and is considered to be strongly correlated with the CME, including the induction of cancer fibrosis and maintenance of CSCs. The aim of the present review was to elucidate a cancer therapy that targets HH signaling by considering the CME, particularly focusing on hypoxia.
Oncology Reports – Spandidos Publications
Published: May 5, 2022
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.