Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
Accumulating evidence suggests the pivotal role of the sympathetic nervous system in the initiation and aggressive progression of tumors, whereas the role of β‑adrenergic receptor (β‑AR) signaling in neuroblastoma (NB) and the underlying regulatory mechanisms have not yet been well elucidated. In the present study, it was demonstrated that the expression of both β1‑AR and β2‑AR was significantly increased in clinical samples of NB compared with those of ganglioneuroma (GN) and ganglioneuroblastoma (GNB), and that β2‑AR is the key β‑adrenergic receptor responsible for NB cell growth. Further investigation showed that the expression levels of the autophagy markers LC3‑Ⅱ, beclin‑1 and unc‑51‑like autophagy kinase 1 (ULK1) were also elevated in NB, compared to the cases of GN and GNB. Moreover, β2‑AR expression was found to be positively associated with autophagy markers in the clinical NB specimens. Cellular functional assays demonstrated that β2‑AR activation promoted NB cell growth and activated the autophagy pathway. Pharmacological inhibition of autophagy with 3‑methyladenine abolished β2‑AR‑induced NB cell growth. Mechanistically, β2‑AR signaling triggers autophagy through CREB‑mediated ULK1 upregulation. In conclusion, the present study uncovered a novel regulatory mechanism of β2‑AR‑activated autophagy in NB cell growth and provides a novel potential therapeutic approach for treating NB by targeting autophagy and the β2‑AR pathway.
Oncology Reports – Spandidos Publications
Published: Oct 23, 2019
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.