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David Hunter, A. Guermazi, G. Lo, G. Lo, A. Grainger, P. Conaghan, R. Boudreau, F. Roemer, F. Roemer (2011)
Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score).Osteoarthritis and cartilage, 19 8
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F. Roemer, M. Nevitt, D. Felson, J. Niu, J. Lynch, M. Crema, C. Lewis, J. Torner, A. Guermazi (2012)
Predictive validity of within-grade scoring of longitudinal changes of MRI-based cartilage morphology and bone marrow lesion assessment in the tibio-femoral joint--the MOST study.Osteoarthritis and cartilage, 20 11
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G. Joseph, C. McCulloch, M. Nevitt, J. Neumann, A. Gersing, M. Kretzschmar, B. Schwaiger, J. Lynch, U. Heilmeier, N. Lane, T. Link (2018)
Tool for osteoarthritis risk prediction (TOARP) over 8 years using baseline clinical data, X‐ray, and MRI: Data from the osteoarthritis initiativeJournal of Magnetic Resonance Imaging, 47
F. Eckstein, A. Guermazi, A. Guermazi, G. Gold, J. Duryea, M. Graverand, W. Wirth, Colin Miller (2014)
Imaging of cartilage and bone: promises and pitfalls in clinical trials of osteoarthritis.Osteoarthritis and cartilage, 22 10
F. Pishgar, A. Guermazi, A. Ashraf-Ganjouei, A. Haj-Mirzaian, F. Roemer, B. Zikria, C. Sereni, M. Hakky, S. Demehri (2021)
Association between Patellofemoral and medial Tibiofemoral compartment osteoarthritis progression: exploring the effect of body weight using longitudinal data from osteoarthritis initiative (OAI)Skeletal Radiology, 50
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F. Roemer, J. Collins, T. Neogi, M. Crema, A. Guermazi (2020)
Association of knee OA structural phenotypes to risk for progression: a secondary analysis from the Foundation for National Institutes of Health Osteoarthritis Biomarkers study (FNIH).Osteoarthritis and cartilage
F. Roemer, C. Kwoh, M. Hannon, David Hunter, F. Eckstein, Zhijie Wang, Robert Boudreau, M. John, M. Nevitt, A. Guermazi (2015)
Can structural joint damage measured with MR imaging be used to predict knee replacement in the following year?Radiology, 274 3
A. Guermazi, F. Roemer, I. Haugen, M. Crema, D. Hayashi (2013)
MRI-based semiquantitative scoring of joint pathology in osteoarthritisNature Reviews Rheumatology, 9
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OoWM YuSP DanielMS HunterDJ. Disease-modifying drugs in osteoarthritis: current understanding and future therapeutics. Expert Opin Emerg Drugs. 2018;23(4):331-47.OoWM YuSP DanielMS HunterDJ. Disease-modifying drugs in osteoarthritis: current understanding and future therapeutics. Expert Opin Emerg Drugs. 2018;23(4):331-47., OoWM YuSP DanielMS HunterDJ. Disease-modifying drugs in osteoarthritis: current understanding and future therapeutics. Expert Opin Emerg Drugs. 2018;23(4):331-47.
H. Guehring, F. Moreau, B. Daelken, C. Ladel, O. Guenther, A. Bihlet, W. Wirth, F. Eckstein, M. Hochberg, P. Conaghan (2021)
The effects of sprifermin on symptoms and structure in a subgroup at risk of progression in the FORWARD knee osteoarthritis trial.Seminars in arthritis and rheumatism, 51 2
( CollinsJE LosinaE NevittMC RoemerFW GuermaziA LynchJA , et al Semiquantitative Imaging biomarkers of knee osteoarthritis progression: data from the foundation for the national institutes of health osteoarthritis biomarkers consortium. Arthritis Rheumatol. 2016;68(10):2422-31.)
CollinsJE LosinaE NevittMC RoemerFW GuermaziA LynchJA , et al Semiquantitative Imaging biomarkers of knee osteoarthritis progression: data from the foundation for the national institutes of health osteoarthritis biomarkers consortium. Arthritis Rheumatol. 2016;68(10):2422-31.CollinsJE LosinaE NevittMC RoemerFW GuermaziA LynchJA , et al Semiquantitative Imaging biomarkers of knee osteoarthritis progression: data from the foundation for the national institutes of health osteoarthritis biomarkers consortium. Arthritis Rheumatol. 2016;68(10):2422-31., CollinsJE LosinaE NevittMC RoemerFW GuermaziA LynchJA , et al Semiquantitative Imaging biomarkers of knee osteoarthritis progression: data from the foundation for the national institutes of health osteoarthritis biomarkers consortium. Arthritis Rheumatol. 2016;68(10):2422-31.
( EcksteinF GuermaziA GoldG DuryeaJ HellioLe GraverandMP WirthW , et al Imaging of cartilage and bone: promises and pitfalls in clinical trials of osteoarthritis. Osteoarthritis Cartilage. 2014;22(10):1516-32.)
EcksteinF GuermaziA GoldG DuryeaJ HellioLe GraverandMP WirthW , et al Imaging of cartilage and bone: promises and pitfalls in clinical trials of osteoarthritis. Osteoarthritis Cartilage. 2014;22(10):1516-32.EcksteinF GuermaziA GoldG DuryeaJ HellioLe GraverandMP WirthW , et al Imaging of cartilage and bone: promises and pitfalls in clinical trials of osteoarthritis. Osteoarthritis Cartilage. 2014;22(10):1516-32., EcksteinF GuermaziA GoldG DuryeaJ HellioLe GraverandMP WirthW , et al Imaging of cartilage and bone: promises and pitfalls in clinical trials of osteoarthritis. Osteoarthritis Cartilage. 2014;22(10):1516-32.
( FelsonDT NevittMC. Blinding images to sequence in osteoarthritis: evidence from other diseases. Osteoarthritis Cartilage. 2009;17(3):281-3.)
FelsonDT NevittMC. Blinding images to sequence in osteoarthritis: evidence from other diseases. Osteoarthritis Cartilage. 2009;17(3):281-3.FelsonDT NevittMC. Blinding images to sequence in osteoarthritis: evidence from other diseases. Osteoarthritis Cartilage. 2009;17(3):281-3., FelsonDT NevittMC. Blinding images to sequence in osteoarthritis: evidence from other diseases. Osteoarthritis Cartilage. 2009;17(3):281-3.
David Hunter, L. Deveza, Jamie Collins, E. Losina, Jeffrey Katz, M. Nevitt, J. Lynch, F. Roemer, A. Guermazi, Michael Bowes, Erik Dam, F. Eckstein, C. Kwoh, Steve Hoffmann, Virginia Kraus (2021)
Multivariable Modeling of Biomarker Data From the Phase I Foundation for the National Institutes of Health Osteoarthritis Biomarkers ConsortiumArthritis Care & Research, 74
( BruynesteynK Van Der HeijdeD BoersM SaudanA PelosoP PaulusH , et al Detecting radiological changes in rheumatoid arthritis that are considered important by clinical experts: influence of reading with or without known sequence. J Rheumatol. 2002;29(11):2306-12.)
BruynesteynK Van Der HeijdeD BoersM SaudanA PelosoP PaulusH , et al Detecting radiological changes in rheumatoid arthritis that are considered important by clinical experts: influence of reading with or without known sequence. J Rheumatol. 2002;29(11):2306-12.BruynesteynK Van Der HeijdeD BoersM SaudanA PelosoP PaulusH , et al Detecting radiological changes in rheumatoid arthritis that are considered important by clinical experts: influence of reading with or without known sequence. J Rheumatol. 2002;29(11):2306-12., BruynesteynK Van Der HeijdeD BoersM SaudanA PelosoP PaulusH , et al Detecting radiological changes in rheumatoid arthritis that are considered important by clinical experts: influence of reading with or without known sequence. J Rheumatol. 2002;29(11):2306-12.
M. Hochberg, A. Guermazi, H. Guehring, A. Aydemir, S. Wax, P. Fleuranceau-Morel, A. Bihlet, I. Byrjalsen, J. Andersen, F. Eckstein (2019)
Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis: The FORWARD Randomized Clinical Trial.JAMA, 322 14
Win Oo, Shirley Yu, M. Daniel, D. Hunter (2018)
Disease-modifying drugs in osteoarthritis: current understanding and future therapeuticsExpert Opinion on Emerging Drugs, 23
D. Felson, D. Felson, M. Nevitt, M. Nevitt (2009)
Blinding images to sequence in osteoarthritis: evidence from other diseases.Osteoarthritis and cartilage, 17 3
DJ Hunter, LA Deveza, JE Collins, E Losina, MC Nevitt, FW Roemer (2022)
Multivariable modeling of biomarker data from the phase 1 Foundation for the NIH Osteoarthritis Biomarkers ConsortiumArthritis Care Res, 74
D. Gensburger, J. Roux, M. Arlot, E. Sornay‐Rendu, P. Ravaud, R. Chapurlat (2010)
Influence of blinding sequence of radiographs on the reproducibility and sensitivity to change of joint space width measurement in knee osteoarthritisArthritis Care & Research, 62
( RoemerFW KwohCK HannonMJ HunterDJ EcksteinF WangZ , et al Can structural joint damage measured with MR imaging be used to predict knee replacement in the following year? Radiology. 2015;274(3):810-20.)
RoemerFW KwohCK HannonMJ HunterDJ EcksteinF WangZ , et al Can structural joint damage measured with MR imaging be used to predict knee replacement in the following year? Radiology. 2015;274(3):810-20.RoemerFW KwohCK HannonMJ HunterDJ EcksteinF WangZ , et al Can structural joint damage measured with MR imaging be used to predict knee replacement in the following year? Radiology. 2015;274(3):810-20., RoemerFW KwohCK HannonMJ HunterDJ EcksteinF WangZ , et al Can structural joint damage measured with MR imaging be used to predict knee replacement in the following year? Radiology. 2015;274(3):810-20.
Osteoarthritis Initiative: A Knee Health Study. OAI Examination Measures
( Osteoarthritis Initiative: A Knee Health Study. OAI Examination Measures. Available from: https://nda.nih.gov/static/docs/ExamMeasures.pdf)
Osteoarthritis Initiative: A Knee Health Study. OAI Examination Measures. Available from: https://nda.nih.gov/static/docs/ExamMeasures.pdfOsteoarthritis Initiative: A Knee Health Study. OAI Examination Measures. Available from: https://nda.nih.gov/static/docs/ExamMeasures.pdf, Osteoarthritis Initiative: A Knee Health Study. OAI Examination Measures. Available from: https://nda.nih.gov/static/docs/ExamMeasures.pdf
A. Guermazi, D. Hayashi, F. Roemer, J. Niu, Emily Quinn, M. Crema, M. Nevitt, J. Torner, C. Lewis, D. Felson (2016)
Brief Report: Partial‐ and Full‐Thickness Focal Cartilage Defects Contribute Equally to Development of New Cartilage Damage in Knee Osteoarthritis: The Multicenter Osteoarthritis StudyArthritis & Rheumatology, 69
( DoreD MartensA QuinnS DingC WinzenbergT ZhaiG , et al Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults. Arthritis Res Ther. 2010;12(6):R222.)
DoreD MartensA QuinnS DingC WinzenbergT ZhaiG , et al Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults. Arthritis Res Ther. 2010;12(6):R222.DoreD MartensA QuinnS DingC WinzenbergT ZhaiG , et al Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults. Arthritis Res Ther. 2010;12(6):R222., DoreD MartensA QuinnS DingC WinzenbergT ZhaiG , et al Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults. Arthritis Res Ther. 2010;12(6):R222.
J. Collins, E. Losina, M. Nevitt, F. Roemer, A. Guermazi, J. Lynch, J. Katz, C. Kwoh, V. Kraus, D. Hunter (2016)
Semi‐Quantitative Imaging Biomarkers of Knee Osteoarthritis Progression: Data from the FNIH OA Biomarkers ConsortiumArthritis & Rheumatism
Felix Eckstein, Manuela Kunz, Matt Schutzer, M. Hudelmaier, Rebecca Jackson, Joseph Yu, Charles Eaton, E. Schneider (2007)
Two year longitudinal change and test-retest-precision of knee cartilage morphology in a pilot study for the osteoarthritis initiative.Osteoarthritis and cartilage, 15 11
JE Collins, E Losina, MC Nevitt, FW Roemer, A Guermazi, JA Lynch (2016)
Semiquantitative Imaging biomarkers of knee osteoarthritis progression: data from the foundation for the national institutes of health osteoarthritis biomarkers consortiumArthritis Rheumatol, 68
C. Peterfy, E. Schneider, M. Nevitt (2008)
The osteoarthritis initiative: report on the design rationale for the magnetic resonance imaging protocol for the knee.Osteoarthritis and cartilage, 16 12
( HochbergMC GuermaziA GuehringH AydemirA WaxS Fleuranceau-MorelP , et al Effect of intra-articular sprifermin vs placebo on femorotibial joint cartilage thickness in patients with osteoarthritis: the FORWARD randomized clinical trial. JAMA. 2019;322(14):1360-70.)
HochbergMC GuermaziA GuehringH AydemirA WaxS Fleuranceau-MorelP , et al Effect of intra-articular sprifermin vs placebo on femorotibial joint cartilage thickness in patients with osteoarthritis: the FORWARD randomized clinical trial. JAMA. 2019;322(14):1360-70.HochbergMC GuermaziA GuehringH AydemirA WaxS Fleuranceau-MorelP , et al Effect of intra-articular sprifermin vs placebo on femorotibial joint cartilage thickness in patients with osteoarthritis: the FORWARD randomized clinical trial. JAMA. 2019;322(14):1360-70., HochbergMC GuermaziA GuehringH AydemirA WaxS Fleuranceau-MorelP , et al Effect of intra-articular sprifermin vs placebo on femorotibial joint cartilage thickness in patients with osteoarthritis: the FORWARD randomized clinical trial. JAMA. 2019;322(14):1360-70.
( HunterDJ DevezaLA CollinsJE LosinaE NevittMC RoemerFW , et al Multivariable modeling of biomarker data from the phase 1 Foundation for the NIH Osteoarthritis Biomarkers Consortium. Arthritis Care Res. 2022;74(7):1142-53.)
HunterDJ DevezaLA CollinsJE LosinaE NevittMC RoemerFW , et al Multivariable modeling of biomarker data from the phase 1 Foundation for the NIH Osteoarthritis Biomarkers Consortium. Arthritis Care Res. 2022;74(7):1142-53.HunterDJ DevezaLA CollinsJE LosinaE NevittMC RoemerFW , et al Multivariable modeling of biomarker data from the phase 1 Foundation for the NIH Osteoarthritis Biomarkers Consortium. Arthritis Care Res. 2022;74(7):1142-53., HunterDJ DevezaLA CollinsJE LosinaE NevittMC RoemerFW , et al Multivariable modeling of biomarker data from the phase 1 Foundation for the NIH Osteoarthritis Biomarkers Consortium. Arthritis Care Res. 2022;74(7):1142-53.
A. Guermazi, F. Eckstein, D. Hayashi, D. Hayashi, F. Roemer, F. Roemer, W. Wirth, Tianzhong Yang, J. Niu, L. Sharma, M. Nevitt, C. Lewis, J. Torner, D. Felson (2015)
Baseline radiographic osteoarthritis and semi-quantitatively assessed meniscal damage and extrusion and cartilage damage on MRI is related to quantitatively defined cartilage thickness loss in knee osteoarthritis: the Multicenter Osteoarthritis Study.Osteoarthritis and cartilage, 23 12
( GuermaziA HayashiD RoemerFW NiuJ QuinnEK CremaMD , et al Brief report: partial- and full-thickness focal cartilage defects contribute equally to development of new cartilage damage in knee osteoarthritis: the multicenter osteoarthritis study. Arthritis Rheumatol. 2017;69(3):560-4.)
GuermaziA HayashiD RoemerFW NiuJ QuinnEK CremaMD , et al Brief report: partial- and full-thickness focal cartilage defects contribute equally to development of new cartilage damage in knee osteoarthritis: the multicenter osteoarthritis study. Arthritis Rheumatol. 2017;69(3):560-4.GuermaziA HayashiD RoemerFW NiuJ QuinnEK CremaMD , et al Brief report: partial- and full-thickness focal cartilage defects contribute equally to development of new cartilage damage in knee osteoarthritis: the multicenter osteoarthritis study. Arthritis Rheumatol. 2017;69(3):560-4., GuermaziA HayashiD RoemerFW NiuJ QuinnEK CremaMD , et al Brief report: partial- and full-thickness focal cartilage defects contribute equally to development of new cartilage damage in knee osteoarthritis: the multicenter osteoarthritis study. Arthritis Rheumatol. 2017;69(3):560-4.
D. Doré, A. Martens, S. Quinn, C. Ding, T. Winzenberg, G. Zhai, J. Pelletier, J. Martel-Pelletier, F. Abram, F. Cicuttini, G. Jones (2010)
Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adultsArthritis Research & Therapy, 12
OAI Examination Measures
( JosephGB McCullochCE NevittMC NeumannJ GersingAS KretzschmarM , et al Tool for osteoarthritis risk prediction (TOARP) over 8 years using baseline clinical data, X-ray, and MRI: data from the osteoarthritis initiative. J Magn Reson Imaging. 2018;47(6):1517-26.)
JosephGB McCullochCE NevittMC NeumannJ GersingAS KretzschmarM , et al Tool for osteoarthritis risk prediction (TOARP) over 8 years using baseline clinical data, X-ray, and MRI: data from the osteoarthritis initiative. J Magn Reson Imaging. 2018;47(6):1517-26.JosephGB McCullochCE NevittMC NeumannJ GersingAS KretzschmarM , et al Tool for osteoarthritis risk prediction (TOARP) over 8 years using baseline clinical data, X-ray, and MRI: data from the osteoarthritis initiative. J Magn Reson Imaging. 2018;47(6):1517-26., JosephGB McCullochCE NevittMC NeumannJ GersingAS KretzschmarM , et al Tool for osteoarthritis risk prediction (TOARP) over 8 years using baseline clinical data, X-ray, and MRI: data from the osteoarthritis initiative. J Magn Reson Imaging. 2018;47(6):1517-26.
K. Bruynesteyn, D. Heijde, M. Boers, A. Saudan, P. Peloso, H. Paulus, H. Houben, B. Griffiths, J. Edmonds, B. Bresnihan, A. Boonen, S. Linden (2002)
Detecting radiological changes in rheumatoid arthritis that are considered important by clinical experts: influence of reading with or without known sequence.The Journal of rheumatology, 29 11
( PishgarF GuermaziA Ashraf-GanjoueiA Haj-MirzaianA RoemerFW ZikriaB , et al Association between Patellofemoral and medial Tibiofemoral compartment osteoarthritis progression: exploring the effect of body weight using longitudinal data from osteoarthritis initiative (OAI). Skeletal Radiol. 2021;50(9):1845-54.)
PishgarF GuermaziA Ashraf-GanjoueiA Haj-MirzaianA RoemerFW ZikriaB , et al Association between Patellofemoral and medial Tibiofemoral compartment osteoarthritis progression: exploring the effect of body weight using longitudinal data from osteoarthritis initiative (OAI). Skeletal Radiol. 2021;50(9):1845-54.PishgarF GuermaziA Ashraf-GanjoueiA Haj-MirzaianA RoemerFW ZikriaB , et al Association between Patellofemoral and medial Tibiofemoral compartment osteoarthritis progression: exploring the effect of body weight using longitudinal data from osteoarthritis initiative (OAI). Skeletal Radiol. 2021;50(9):1845-54., PishgarF GuermaziA Ashraf-GanjoueiA Haj-MirzaianA RoemerFW ZikriaB , et al Association between Patellofemoral and medial Tibiofemoral compartment osteoarthritis progression: exploring the effect of body weight using longitudinal data from osteoarthritis initiative (OAI). Skeletal Radiol. 2021;50(9):1845-54.
K. Bloecker, W. Wirth, A. Guermazi, David Hunter, H. Resch, J. Hochreiter, F. Eckstein (2015)
Relationship Between Medial Meniscal Extrusion and Cartilage Loss in Specific Femorotibial Subregions: Data From the Osteoarthritis InitiativeArthritis Care & Research, 67
ObjectiveTo assess the association of worsening of magnetic resonance imaging (MRI) semi-quantitative (SQ) tissue features with concurrent change in quantitative (Q) cartilage thickness measurements over 24 months within the Foundation for the National Institutes of Health (FNIH) Biomarker Consortium study.MethodsIn all, 599 participants were included. SQ assessment included cartilage damage, meniscal extrusion and damage, osteophytes, bone marrow lesions (BMLs), and effusion- and Hoffa-synovitis. Change in medial compartment Q cartilage thickness was stratified by concurrent ipsicompartmental SQ changes. Between-group comparisons were performed using analysis of covariance (ANCOVA) with adjustment for age, sex, and body mass index (BMI). Results were presented as adjusted mean difference.ResultsKnees with any increase in SQ cartilage scores in the medial compartment (n = 268) showed more Q cartilage loss compared to knees that remained stable (mean adjusted difference [MAD] = -0.16 mm, 95% confidence interval [CI]: [-0.19, -0.13] mm). Knees with any increase in meniscal extrusion in the medial compartment (n = 98) showed more Q cartilage loss than knees without (MAD = -0.18 mm, 95% CI: [-0.22, -0.14] mm. Comparable findings were seen for meniscal damage worsening. Regarding BMLs, an increase by one subregion resulted in a MAD of Q cartilage loss of -0.10 mm, 95% CI: [-0.14, -0.06] mm, while this effect almost tripled for change in two or more subregions. Increase in either effusion- and/or Hoffa-synovitis by one grade resulted in a MAD of -0.07 mm, 95% CI: [-0.10, -0.03] mm.ConclusionWorsening of SQ cartilage damage, meniscal extrusion and damage, number of subregions affected by BML, maximum size of BMLs and worsening of effusion- and/or Hoffa synovitis is associated with increased Q cartilage loss.
Cartilage – SAGE
Published: Mar 1, 2023
Keywords: cartilage; MRI; knee; osteoarthritis
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