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G., J.
HIGH-AFFINITY UPTAKE OF y-AMINOBUTYRIC ACID IN CULTURED GLIAL AND NEURONAL CELLS
- Publisher
- SAGE
- Copyright
- © 1989 Fund for the Replacement of Animals in Medical Experiments
- ISSN
- 0261-1929
- eISSN
- 2632-3559
- DOI
- 10.1177/026119298901600306
- Publisher site
- See Article on Publisher Site
Abstract
The sodium salt of valproic acid (VPA) is an antiepileptic drug, which is effective in the treatment of several types of epilepsy. The drug has been postulated to exert its anticonvulsant effects by interaction with GABA-ergic systems in the brain. Results show a high-affinity uptake for sodium valproate in primary astroglial cultures from newborn rat cerebral cortex, with the kinetic parameters Km and Vmax not significantly different from those observed for GABA. This uptake was shown to interact with astroglial GABA transport in culture, with an increased Km value for GABA uptake. Since failure in GABA-ergic systems is postulated to be one of the major factors in the aetiology of epilepsy, it is interesting to note that the transport system for GABA in astrocytes is affected by sodium valproate.
Journal
Alternatives to Laboratory Animals – SAGE
Published: Mar 1, 1989