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Therapeutic Effect of Electroacupuncture in a P75 Knockout Mouse Model of Progressive Hearing Loss

Therapeutic Effect of Electroacupuncture in a P75 Knockout Mouse Model of Progressive Hearing Loss Letter loss. Cell loss of the spiral gan- subjective symptoms of tinnitus or Therapeutic effect glion neurons (SGNs) and hair cell hearing loss. However, the of electroacupuncture degeneration at the basal turn of molecular mechanisms underlying in a p75 knockout mouse the cochlea are seen in p75(−/−) the therapeutic effect of EA stimula- mice from 3 months of age. tion for hearing loss remain unclear. model of progressive Furthermore, from 3 to 6 months Thus, to determine whether EA hearing loss of age, the hearing thresholds of stimulation is useful for the preven- p75(−/−) mice are gradually raised; tion of hearing loss, we used a p75 and after 6 months of age, the mice (−/−) mouse model of mostly exhibit hearing loss. progressive-onset hearing loss. Neurotrophin receptor p75 NTR Several previous reports have The Ting Gong (SI19; Small (p75 ) knockout mice (p75 indicated that electroacupuncture Intestine 19) and the Yifeng (TE17; (−/−) mice) provide a good animal (EA) stimulation may improve Triple Energiser meridian 17) are model of progressive-onset hearing Figure 1 Haematoxylin and eosin (H&E) staining of cochleae from mice with and without electroacupuncture (EA) stimulation. (A) H&E staining of the organ of Corti in the basal http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acupuncture in Medicine SAGE

Therapeutic Effect of Electroacupuncture in a P75 Knockout Mouse Model of Progressive Hearing Loss

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References (8)

Publisher
SAGE
Copyright
© 2014 British Medical Acupuncutre Society
ISSN
0964-5284
eISSN
1759-9873
DOI
10.1136/acupmed-2013-010450
pmid
24140759
Publisher site
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Abstract

Letter loss. Cell loss of the spiral gan- subjective symptoms of tinnitus or Therapeutic effect glion neurons (SGNs) and hair cell hearing loss. However, the of electroacupuncture degeneration at the basal turn of molecular mechanisms underlying in a p75 knockout mouse the cochlea are seen in p75(−/−) the therapeutic effect of EA stimula- mice from 3 months of age. tion for hearing loss remain unclear. model of progressive Furthermore, from 3 to 6 months Thus, to determine whether EA hearing loss of age, the hearing thresholds of stimulation is useful for the preven- p75(−/−) mice are gradually raised; tion of hearing loss, we used a p75 and after 6 months of age, the mice (−/−) mouse model of mostly exhibit hearing loss. progressive-onset hearing loss. Neurotrophin receptor p75 NTR Several previous reports have The Ting Gong (SI19; Small (p75 ) knockout mice (p75 indicated that electroacupuncture Intestine 19) and the Yifeng (TE17; (−/−) mice) provide a good animal (EA) stimulation may improve Triple Energiser meridian 17) are model of progressive-onset hearing Figure 1 Haematoxylin and eosin (H&E) staining of cochleae from mice with and without electroacupuncture (EA) stimulation. (A) H&E staining of the organ of Corti in the basal

Journal

Acupuncture in Medicine – SAGE

Published: Feb 1, 2014

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