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ATLA 24, 531-608, 1996 Second Italian CellTox Conference 531 Introduction The Second National Conference of CellTox, held in Ivrea, Italy, on 16-18 October 1995, in collaboration with the Molecular and Cellular Toxicology Group of the Italian Toxicology Society, was attended by 111 scientists from various national laboratories. The conference was opened by the main lecturer, Ian White (MRC Toxicology Unit, University of Leicester, UK), who discussed Genetically Manipulated Models for Studies of Toxicity Mechanisms. The scientific presentations, 39 communications and 29 posters, were organised into sessions on genotoxicity, xenobiotic biotransformation, human cells for studies of metabolism and toxicity, free-radicals, apoptosis, and organ toxicity models for acute toxicity evaluation, activation, inactivation and risk evaluation. Invited keynote lectures were given by Antonietta Martelli (University of Genoa, Italy), on Human Hepatocyte Primary Cultures in Genotoxicity Studies, Mario Comporti (University of Siena, Italy), on Iron Release and In Vitro Ageing in Red Blood Cells, Giorgio Bellomo (University of Turin, Italy), on Cytoskeleton Alterations by Cholesterol Oxides in Endothelial Cells, and Bice Fubini (University of Turin, Italy), on Surface Chemistry and Cellular Models for the Evaluation of Solid Particulate Toxicity. The conference concluded with a round table discussion on Recent Developments in the Application and Validation of Alternative Methods, with the participation of Co.rrado Galli (University of Milan, Italy), Raffaella Pirovano <RBM, Ivrea, Italy), Michael Balls ·(European Centre for the Validation of Alternative Methods, Ispra, Italy), Annalaura Stammati (lstituto Superiore di Sanita, Rome, Italy), Odile De Silva (L'Oreal, Aulnay-sous-Bois, France), Pierre Gautheron (MSD-Chibret, Riom, France), and Ian Kimber (Zeneca, Macclesfield, UK). The main conclusions reached were that: a) validation strategies should be perfected; b) the general design should be improved, especially where the predictivity of the various models is concerned; for example, a model must define exactly how the test results are used to predict a given toxicity endpoint; and c) clear objectives and an independent management should be established. Margherita Ferro Facolta' di Medicina e Chirurgia Istituto di Patologia Generale Universita' Degli Studi di Genova Via L.B. Alberti 2 16132 Genova Italy
Alternatives to Laboratory Animals – SAGE
Published: Aug 1, 1996
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