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K. Westerterp (2009)
Dietary fat oxidation as a function of body fatCurrent Opinion in Lipidology, 20
A. Bennett (2010)
The use of Human Tissues and Cells in Biomedical Research: The Unusual SuspectsAlternatives to Laboratory Animals, 38
K. Tsintzas, K. Jewell, M. Kamran, D. Laithwaite, T. Boonsong, J. Littlewood, I. Macdonald, A. Bennett (2006)
Differential regulation of metabolic genes in skeletal muscle during starvation and refeeding in humansThe Journal of Physiology, 575
ATLA 39, 119–120, 2011 119 News from the FAL The Relevance of Fat Oxidation Capacity to Obesity in Human Subjects The FRAME Alternatives Laboratory (FAL) was founded in 1983 at the University of Nottingham Medical School. Now under the leadership of Dr Andy Bennett, the FAL is con- tinuing to discover and develop real alterna- tives to the use of animals in research and testing. Here, Andy outlines another of his cur- rent key projects, in a discussion with Rita Seabra: 1. What disease are you studying in the project? The project is about obesity, but it has wider- ranging implications, because obesity is a pre- cursor to a range of health problems, including 5. Is there an animal model currently in use diabetes, and cardiovascular and liver disease. in other similar projects elsewhere? Several rodent models are used in research on 2. Who are your collaborators? obesity, but none of them adequately replicate We work with metabolic physiologists, Dr human obesity and obesity-associated condi- Kostas Tsintzas and Professor Ian MacDonald, tions. both from the School of Biomedical Sciences at Diet-induced models attempt to reproduce the the University of Nottingham. origin of the disease. As each strain consists of
Alternatives to Laboratory Animals – SAGE
Published: May 1, 2011
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