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The Necessity of Biokinetic Information in the Interpretation of In Vitro Toxicity Data

The Necessity of Biokinetic Information in the Interpretation of In Vitro Toxicity Data Data derived from in vitro toxicity studies are not directly applicable in an assessment of the toxicity of compounds in intact organisms. The major limitation is the lack of knowledge of biokinetic behaviour in vivo. Since the toxicity of a compound will be determined by the critical concentration (or other dose metric) of the critical compound (or a metabolite thereof) at the critical site of toxic action, biokinetic behaviour must be taken into account. Possibilities of biokinetic modelling on the basis of in vitro and other non-animal data are discussed, and the application of the results in hazard and risk-assessment schedules is considered. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alternatives to Laboratory Animals SAGE

The Necessity of Biokinetic Information in the Interpretation of In Vitro Toxicity Data

Alternatives to Laboratory Animals , Volume 30 (2_suppl): 7 – Dec 1, 2002

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References (40)

Publisher
SAGE
Copyright
© 2002 Fund for the Replacement of Animals in Medical Experiments
ISSN
0261-1929
eISSN
2632-3559
DOI
10.1177/026119290203002S13
Publisher site
See Article on Publisher Site

Abstract

Data derived from in vitro toxicity studies are not directly applicable in an assessment of the toxicity of compounds in intact organisms. The major limitation is the lack of knowledge of biokinetic behaviour in vivo. Since the toxicity of a compound will be determined by the critical concentration (or other dose metric) of the critical compound (or a metabolite thereof) at the critical site of toxic action, biokinetic behaviour must be taken into account. Possibilities of biokinetic modelling on the basis of in vitro and other non-animal data are discussed, and the application of the results in hazard and risk-assessment schedules is considered.

Journal

Alternatives to Laboratory AnimalsSAGE

Published: Dec 1, 2002

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