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The LD50 Value — a Frequently Misapplied Concept

The LD50 Value — a Frequently Misapplied Concept ATLA 12, 75-79,1984 The LD50 Value - a Frequently Misapplied Concept V.K.Brown 7 Greenfields, Willington Street, Maidstone, Kent ME15 BET, UK A substantial understanding ofthe mechanistic processes associated with toxic interactions has been developed in recent years and will continue to improve as the available techniques for investigations become more refined. However, there remains an intellectual hurdle that troubles many people concerned with toxicology. The hurdle is related to the handling of the toxiological information that is generated and is seen to be imprecise. This imprecision contrasts with the high level of precision that is associated with data in the physical sciences. A very long time ago, Leonardo da Vinci is reputed to have stated that: ''There is no certainty in science where mathematics cannot be applied." Now, in the twentieth century, we accept that there is little that is certain in toxicology, but we apply the mathematical principles of probability to our findings in order to achieve a level of scientific respectability. The objective here is to review briefly the importance of quantification in relation to acute toxicology with, of necessity , special reference to the much abused LD50 value. There is a school of thought that repudiates http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alternatives to Laboratory Animals SAGE

The LD50 Value — a Frequently Misapplied Concept

Brown, V. K.
Alternatives to Laboratory Animals , Volume 12 (2): 5 – Dec 1, 1984
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References (31)

Publisher
SAGE
Copyright
© 1984 Fund for the Replacement of Animals in Medical Experiments
ISSN
0261-1929
eISSN
2632-3559
DOI
10.1177/026119298401200203
Publisher site
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Abstract

ATLA 12, 75-79,1984 The LD50 Value - a Frequently Misapplied Concept V.K.Brown 7 Greenfields, Willington Street, Maidstone, Kent ME15 BET, UK A substantial understanding ofthe mechanistic processes associated with toxic interactions has been developed in recent years and will continue to improve as the available techniques for investigations become more refined. However, there remains an intellectual hurdle that troubles many people concerned with toxicology. The hurdle is related to the handling of the toxiological information that is generated and is seen to be imprecise. This imprecision contrasts with the high level of precision that is associated with data in the physical sciences. A very long time ago, Leonardo da Vinci is reputed to have stated that: ''There is no certainty in science where mathematics cannot be applied." Now, in the twentieth century, we accept that there is little that is certain in toxicology, but we apply the mathematical principles of probability to our findings in order to achieve a level of scientific respectability. The objective here is to review briefly the importance of quantification in relation to acute toxicology with, of necessity , special reference to the much abused LD50 value. There is a school of thought that repudiates

Journal

Alternatives to Laboratory Animals – SAGE

Published: Dec 1, 1984

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