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The Classical LD50 Test: Signs of Hopelessness … … and Glimmers of Hope

The Classical LD50 Test: Signs of Hopelessness … … and Glimmers of Hope ATLA 16 118-119 1988 .. . . . The Classical LD50 Test: Signs of Hopelessness ... and Glimmers of Hope It is now widely recognised among toxicologists and regulators that the precise LD50 value reputedly provided by the formal or classical LD50 test is an unobtainable illusion, so the performance of such tests is unnecessary and morally unacceptable. It is therefore surprising that Table 14 of the first set of statistics provided by the Home Office on procedures carried out under the Animals (Scientific Procedures) Act 1986 , reveals that 111,313 procedures performed in Britain in 1987 were classified under the heading: "acute and subacute whole body lethal toxicity tests ( = 'formal' LD50 or LC50 tests)". Why are formal LD50 tests still performed in Britain today? The answer appears to be that some foreign regulators still demand "precise LD50 values", and industrial toxicologists are prepared to satisfy them in order to get their companies' products registered. In a very powerful editorial , Gerhard Zbinden recently put the position of the average industrial toxicologist like this: If I want to keep my job, I am better off doing toxicology their way and forgetting about creativity. And if I hope http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alternatives to Laboratory Animals SAGE

The Classical LD50 Test: Signs of Hopelessness … … and Glimmers of Hope

Alternatives to Laboratory Animals , Volume 16 (2): 2 – Dec 1, 1988

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References (1)

Publisher
SAGE
Copyright
© 1988 Fund for the Replacement of Animals in Medical Experiments
ISSN
0261-1929
eISSN
2632-3559
DOI
10.1177/026119298801600201
Publisher site
See Article on Publisher Site

Abstract

ATLA 16 118-119 1988 .. . . . The Classical LD50 Test: Signs of Hopelessness ... and Glimmers of Hope It is now widely recognised among toxicologists and regulators that the precise LD50 value reputedly provided by the formal or classical LD50 test is an unobtainable illusion, so the performance of such tests is unnecessary and morally unacceptable. It is therefore surprising that Table 14 of the first set of statistics provided by the Home Office on procedures carried out under the Animals (Scientific Procedures) Act 1986 , reveals that 111,313 procedures performed in Britain in 1987 were classified under the heading: "acute and subacute whole body lethal toxicity tests ( = 'formal' LD50 or LC50 tests)". Why are formal LD50 tests still performed in Britain today? The answer appears to be that some foreign regulators still demand "precise LD50 values", and industrial toxicologists are prepared to satisfy them in order to get their companies' products registered. In a very powerful editorial , Gerhard Zbinden recently put the position of the average industrial toxicologist like this: If I want to keep my job, I am better off doing toxicology their way and forgetting about creativity. And if I hope

Journal

Alternatives to Laboratory AnimalsSAGE

Published: Dec 1, 1988

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