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Side Effects of Water-Soluble Contrast Media in Lumbar Myelography:

Side Effects of Water-Soluble Contrast Media in Lumbar Myelography: FROM THE DEPARTMENT OF DIAGNOSTIC RADIOLOGY II, SAHLGRENSKA SJUKHUSET, 41345 GOTHENBURG, SWEDEN. SIDE EFFECTS OF WATER-SOLUBLE CONTRAST :MEDIA IN LUMBAR MYELOGRAPHY L. lRSTAM Water-soluble contrast media of the Abrodil group have been used in Scan­ dinavia for some thirty years. These have an irritating effect on the medulla and the nerve roots and cannot be used without spinal anaesthesia, which is however not inert and adds to the toxic effect (GONSETTE 1971). Most of the complica­ tions of lumbar myelography are well known and have been dealt with in the comprehensive investigation of AHLGREN & PRAESTHOLM (1969) in which the frequency of side effects was stated to be more than 60 per cent. Many attempts have been made to develop less irritating contrast media and have now and then been accepted with enthusiasm until later experience has proved them to have serious side effects. This occurred, for example, with SH 617 (Schering), first described as a long desired newcomer (ZEITLER 1965), but later considered unacceptable (FISCHER 1965, LINDGREN & TORNELL 1969). CAmPBELL et coll. (1964) investigated the iothalamate compounds for their toxicity when injected intracisternally in animals. An increasing number of publications have since reported the use of iothalamate http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Radiologica. Diagnosis SAGE

Side Effects of Water-Soluble Contrast Media in Lumbar Myelography:

Acta Radiologica. Diagnosis , Volume 14 (6): 10 – Aug 30, 2016

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Publisher
SAGE
Copyright
Copyright © 2019 by The Foundation Acta Radiologica
ISSN
0567-8056
eISSN
ISSN: 0567-8056
DOI
10.1177/028418517301400603
Publisher site
See Article on Publisher Site

Abstract

FROM THE DEPARTMENT OF DIAGNOSTIC RADIOLOGY II, SAHLGRENSKA SJUKHUSET, 41345 GOTHENBURG, SWEDEN. SIDE EFFECTS OF WATER-SOLUBLE CONTRAST :MEDIA IN LUMBAR MYELOGRAPHY L. lRSTAM Water-soluble contrast media of the Abrodil group have been used in Scan­ dinavia for some thirty years. These have an irritating effect on the medulla and the nerve roots and cannot be used without spinal anaesthesia, which is however not inert and adds to the toxic effect (GONSETTE 1971). Most of the complica­ tions of lumbar myelography are well known and have been dealt with in the comprehensive investigation of AHLGREN & PRAESTHOLM (1969) in which the frequency of side effects was stated to be more than 60 per cent. Many attempts have been made to develop less irritating contrast media and have now and then been accepted with enthusiasm until later experience has proved them to have serious side effects. This occurred, for example, with SH 617 (Schering), first described as a long desired newcomer (ZEITLER 1965), but later considered unacceptable (FISCHER 1965, LINDGREN & TORNELL 1969). CAmPBELL et coll. (1964) investigated the iothalamate compounds for their toxicity when injected intracisternally in animals. An increasing number of publications have since reported the use of iothalamate

Journal

Acta Radiologica. DiagnosisSAGE

Published: Aug 30, 2016

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