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- SAGE
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- Copyright © 2020 by SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses
- ISSN
- 1758-8359
- eISSN
- 1758-8359
- DOI
- 10.1177/1758834012446008
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Abstract
Pancreatic cancer has historically proven resistant to anticancer agents. On the one hand, drugs might be more efficient if higher levels could be achieved at the tumor site rather than the normal tissues. On the other hand, the thick stroma and the relative absence of abundant vessels may account at least partially for the failure of successive clinical trials to demonstrate effective treatments in this type of malignancy. In this context, the development and testing in clinical trials of treatment strategies that aim to optimize drug delivery is an important target in improving the prognosis of patients with pancreatic cancer.
Journal
Therapeutic Advances in Medical Oncology – SAGE
Published: Apr 30, 2012
Keywords: chemotherapy,drug delivery,folfirinox,gemcitabine,pancreatic cancer,resistance