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ATLA 33, 189–190, 2005 189 For many years cell-based in vitro systems have been Could Microchip Technology Replace In used to decipher the mechanisms of action and toxic Vivo Toxicology Studies? effects of biogenic and synthetic substances. The limita- tions of many of these systems include the fact that only Recent developments have enabled the miniaturisation a few parameters can be measured with each system of chemical reactions and cell culture systems such and while the effect of substances on one organ or tis- that high throughput experiments can be carried out sue may be examined, the information from such stud- using “lab on a chip” technology, whereby the amount ies is incomplete and difficult to extrapolate to in vivo of reagents or cells required is reduced to minute pro- situations. The miniaturised cell array systems portions. Michael Shuler, a chemical engineer from described here will allow detailed assessment of the Cornell University, has taken this concept one step effects of barriers to absorption, the rate of biodistribu- further and produced “animal on a chip” technology tion, the specificity of drug targeting and the rate of which has the potential to predict drug and chemical elimination to all be
Alternatives to Laboratory Animals – SAGE
Published: Jun 1, 2005
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