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News & Views ATLA 34, 467–468, 2006 467 Tamborrini, M., Werz, D.B., Frey, J., Pluschke, G. & Anthrax 1 Seeberger, P.H. (2006). Anti-Carbohydrate Anti- bodies for the Detection of Anthrax Spores. Ange- As the bioterrorism threat becomes ever more- wandte Chemie (International edition in English). serious, there is still a 75% fatality rate after anthrax E-Pub ahead of print. Website http://www.ncbi.nlm. inhalation, even with the use of antibiotics. There are nih.gov/entrez/query.fcgi?CMD=search&DB= also fears that, as well as the natural development of pu bmed (Accessed 01.09.06). resistance, the causative agent, Bacillus anthracis, Berg, T., Suddes, H., Morrice, G. & Hornitzky, M. could be deliberately mutated to resist all available (2006). Comparison of PCR, culture and micros- antibiotics. Therefore, ideally, another kind of treat- copy of blood smears for the diagnosis of anthrax in ment is needed, and this is just what Basha et al. sheep and cattle. Letters in Applied Microbiology 43, have been working to produce. By identifying multi- 181–186. ple peptides that can bind to the anthrax-toxin recep- tors, they managed to neutralise the toxin in rats. Multiple peptides permitted binding at multiple sites, and this had the effect of making the inhibitor more Ethical Stem Cells? potent. This may also http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alternatives to Laboratory Animals SAGE

News & Views

Alternatives to Laboratory Animals , Volume 34 (5): 2 – Oct 1, 2006
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References (3)

Publisher
SAGE
Copyright
© 2006 Fund for the Replacement of Animals in Medical Experiments
ISSN
0261-1929
eISSN
2632-3559
DOI
10.1177/026119290603400507
Publisher site
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Abstract

ATLA 34, 467–468, 2006 467 Tamborrini, M., Werz, D.B., Frey, J., Pluschke, G. & Anthrax 1 Seeberger, P.H. (2006). Anti-Carbohydrate Anti- bodies for the Detection of Anthrax Spores. Ange- As the bioterrorism threat becomes ever more- wandte Chemie (International edition in English). serious, there is still a 75% fatality rate after anthrax E-Pub ahead of print. Website http://www.ncbi.nlm. inhalation, even with the use of antibiotics. There are nih.gov/entrez/query.fcgi?CMD=search&DB= also fears that, as well as the natural development of pu bmed (Accessed 01.09.06). resistance, the causative agent, Bacillus anthracis, Berg, T., Suddes, H., Morrice, G. & Hornitzky, M. could be deliberately mutated to resist all available (2006). Comparison of PCR, culture and micros- antibiotics. Therefore, ideally, another kind of treat- copy of blood smears for the diagnosis of anthrax in ment is needed, and this is just what Basha et al. sheep and cattle. Letters in Applied Microbiology 43, have been working to produce. By identifying multi- 181–186. ple peptides that can bind to the anthrax-toxin recep- tors, they managed to neutralise the toxin in rats. Multiple peptides permitted binding at multiple sites, and this had the effect of making the inhibitor more Ethical Stem Cells? potent. This may also

Journal

Alternatives to Laboratory Animals – SAGE

Published: Oct 1, 2006

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