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News & Views ATLA 45, 303–304, 2017 303 Bara, J.J., Herrmann, M., Evans C.H., Miclau, T., Questionnaire on Preclinical Research Ratcliffe, A. & Richards R.G. (2016). Improving in Bone Tissue Engineering — How translation success of cell-based therapies in orthopaedics. Journal of Orthopaedic Research 34, Translational are our Models? 17–21. Bone replacements are required to treat critical size bone defects and fracture non-unions. These cases are accompanied by long hospitali- sations and absenteeism, resulting in a signifi- Metabolomics-based Approach with cant socio-economic burden. Currently, the gold Neuronal Cells standard treatment in the clinic is an autolo- gous or allogenic bone graft. However, this is An untargeted metabolite profiling approach associated with a number of disadvantages, has been used to detect metabolic changes in including donor site morbidity, disease trans- neuronal cells in response to insecticides. The mission, immunogenicity, limitations in the study, which was published in the Journal of amount of available material, and poor perfor- Applied Toxicology, employed gas chromatog- mance of the graft material. Bone tissue engi- raphy–mass spectrometry to characterise the neering presents a promising alternative to effects of two different classes of neurotoxic such treatments, and has been extensively insecticides on a neuronal cell line. The cells investigated http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alternatives to Laboratory Animals SAGE

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Publisher
SAGE
Copyright
© 2017 Fund for the Replacement of Animals in Medical Experiments
ISSN
0261-1929
eISSN
2632-3559
DOI
10.1177/026119291704500609
Publisher site
See Article on Publisher Site

Abstract

ATLA 45, 303–304, 2017 303 Bara, J.J., Herrmann, M., Evans C.H., Miclau, T., Questionnaire on Preclinical Research Ratcliffe, A. & Richards R.G. (2016). Improving in Bone Tissue Engineering — How translation success of cell-based therapies in orthopaedics. Journal of Orthopaedic Research 34, Translational are our Models? 17–21. Bone replacements are required to treat critical size bone defects and fracture non-unions. These cases are accompanied by long hospitali- sations and absenteeism, resulting in a signifi- Metabolomics-based Approach with cant socio-economic burden. Currently, the gold Neuronal Cells standard treatment in the clinic is an autolo- gous or allogenic bone graft. However, this is An untargeted metabolite profiling approach associated with a number of disadvantages, has been used to detect metabolic changes in including donor site morbidity, disease trans- neuronal cells in response to insecticides. The mission, immunogenicity, limitations in the study, which was published in the Journal of amount of available material, and poor perfor- Applied Toxicology, employed gas chromatog- mance of the graft material. Bone tissue engi- raphy–mass spectrometry to characterise the neering presents a promising alternative to effects of two different classes of neurotoxic such treatments, and has been extensively insecticides on a neuronal cell line. The cells investigated

Journal

Alternatives to Laboratory AnimalsSAGE

Published: Dec 1, 2017

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