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News & Views ATLA 39, 3–8, 2011 3 Although human RAS-regulated pathways have Human Studies Reveal Genetic been studied in depth, they are very complex and Mutation in Renal Cancer involve a variety of proteins functioning down- stream of RAS. The current approach involved A multinational collaboration has identified a the use of C. elegans as a model organism to gene that is mutated in a third of patients with study RAS, because its signalling pathways are the most common form of renal cancer, clear simpler than those in humans. This strategy cell renal carcinoma (ccRCC). allowed the identification of critical points that Nine out of ten renal cancer cases are renal influence normal cellular development, and, if cell carcinomas (RCCs), of which ccRCCs are similar mechanisms occur in human cancers, the most common subtype and account for 80% particularly in pancreatic cancers which gener- of RCCs. Two genes located on chromosome 3, ally have RAS mutations, the findings might VHL and SETD2, were already known to be point toward new therapeutic targets. associated with renal cancer, but the identifica- tion of another gene, PBRM1, is an important Graffenreid, E. (2011). Roundworm unlocks pan- step, since this gene was mutated in 88 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alternatives to Laboratory Animals SAGE

News & Views

Alternatives to Laboratory Animals , Volume 39 (1): 6 – Mar 1, 2011
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Publisher
SAGE
Copyright
© 2011 Fund for the Replacement of Animals in Medical Experiments
ISSN
0261-1929
eISSN
2632-3559
DOI
10.1177/026119291103900117
Publisher site
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Abstract

ATLA 39, 3–8, 2011 3 Although human RAS-regulated pathways have Human Studies Reveal Genetic been studied in depth, they are very complex and Mutation in Renal Cancer involve a variety of proteins functioning down- stream of RAS. The current approach involved A multinational collaboration has identified a the use of C. elegans as a model organism to gene that is mutated in a third of patients with study RAS, because its signalling pathways are the most common form of renal cancer, clear simpler than those in humans. This strategy cell renal carcinoma (ccRCC). allowed the identification of critical points that Nine out of ten renal cancer cases are renal influence normal cellular development, and, if cell carcinomas (RCCs), of which ccRCCs are similar mechanisms occur in human cancers, the most common subtype and account for 80% particularly in pancreatic cancers which gener- of RCCs. Two genes located on chromosome 3, ally have RAS mutations, the findings might VHL and SETD2, were already known to be point toward new therapeutic targets. associated with renal cancer, but the identifica- tion of another gene, PBRM1, is an important Graffenreid, E. (2011). Roundworm unlocks pan- step, since this gene was mutated in 88

Journal

Alternatives to Laboratory Animals – SAGE

Published: Mar 1, 2011

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