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Scientific Articles The Journal for Vascular Ultrasound 32(1):14–16, 2008 Macro and Microvascular Effects of Hyperglycemia in Type 2 Diabetic Patients Cheryl M. Bongiovanni, PhD, RVT, CWS Introduction effect of high- and low-sugar diets on insulin resis- tance and vascular risk. Insulin resistance and arterial The incidence of obesity and diabetes in the United stiffness were assessed as effects of the otherwise- States and worldwide is increasing at alarming identical diets. In the healthy, nondiabetic male sub- 1,2 rates. A concomitant 2- to 4-fold risk for develop- jects studied, a high sucrose diet had no demonstrable, ment of cardiovascular disease accompanies this epi- detrimental effect on insulin resistance or measures of 3,4 demic. Despite intense interest and a growing body vascular risk, despite documented increases in total of research, the long-term impact of dietary carbohy- and LDL cholesterol and increased triglycerides. In drate type, especially sucrose, on insulin resistance other studies, there is increasing evidence that the se- and the development of diabetes and atherosclerosis is rum glucose “spike” associated with the postprandial not established. Insulin resistance is a primary feature state is an important contribution to the development of type 2 diabetes and heralds impending glucose in- 22 of
Journal for Vascular Ultrasound – SAGE
Published: Mar 1, 2008
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