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(1984)
The Induction of Mitotic Gene Conversion in the Yeast Saccharomyces cerevisiae JD 1 , by Ten Selected Compounds in the IPCS Collaborative Study on Short - term Tests
(1983)
Elsevier/North Holland
J. Ashby, F. Serres, M. Draper, M. Ishidate, B. Matter, M. Shelby (1983)
The two IPCS collaborative studies on short-term tests for genotoxicity and carcinogenicityMutation Research, 109
T. Tsutsui, H. Maizumi, J. Mclachlan, J. Barrett (1983)
Aneuploidy induction and cell transformation by diethylstilbestrol: a possible chromosomal mechanism in carcinogenesis.Cancer research, 43 8
L. Secker-Walker (1996)
Catalog of Chromosome Aberrations in CancerBritish Journal of Cancer, 73
G. Karayalcin, A. Shanske, R. Honigman (1981)
Wilms' tumor in a 13-year old girl with trisomy 18.American journal of diseases of children, 135 7
J. Parry, D. Sharp, E. Parry (1979)
Detection of mitotic and meiotic aneuploidy in the yeast Saccharomyces cerevisiae.Environmental Health Perspectives, 31
G. Williams, E. Weisburger, J. Weisburger (1971)
Isolation and long-term cell culture of epithelial-like cells from rat liver.Experimental cell research, 69 1
J. Parry, F. Zimmerman (1976)
The detection of monosomic colonies produced by mitotic chromosome non-disjunction in the yeast Saccharomyces cerevisiae.Mutation research, 36 1
N. Danford, J. Parry (1982)
Abnormal cell division in cultured human fibroblasts after exposure to diethylstilboestrol.Mutation research, 103 3-6
(1978)
Mixed teratoid tumours of the liver and neck in trisomy
D. Gallwitz, C. Donath, C. Sander (1983)
A yeast gene encoding a protein homologous to the human c-has/bas proto-oncogene productNature, 306
W. Cavenee, W. Cavenee, T. Dryja, R. Phillips, W. Benedict, R. Godbout, B. Gallie, A. Murphree, L. Strong, Raymond White (1983)
Expression of recessive alleles by chromosomal mechanisms in retinoblastomaNature, 305
(1977)
The Cytogenetics of Early Human Fetuses. A thesis presented in fulfilment of the requirement for the degree of Doctor of Philosophy in the
E. Parry, N. Danford, J. Parry (1982)
Differential staining of chromosomes and spindle and its use as an assay for determining the effect of diethylstilboestrol on cultured mammalian cells.Mutation research, 105 4
B. Dean, G. Hodson-Walker (1979)
An in vitro chromosome assay using cultured rat-liver cells.Mutation research, 64 5
F. Eckardt, R. Haynes (1980)
Quantitative measures of mutagenicity and mutability based on mutant yield data.Mutation research, 74 6
(1981)
Overview of Study and Test Chemical Activities
Effects of 10 Compounds on Levels of Chromosome Aberrations and Aneuploidy in a Chinese Hamster Fibroblast Cell Line
N. Danford (1984)
Measurement of levels of aneuploidy in mammalian cells using a modified hypotonic treatment.Mutation research, 139 3
Margaret Robinson, Maureen McCorquodale (1981)
Trisomy 18 and neurogenic neoplasia.The Journal of pediatrics, 99 3
(1978)
Chromosome Anomalies Associated with Fetal Malformations
M. Dische, H. Gardner (1978)
Mixed teratoid tumors of the liver and neck in trisomy 13.American journal of clinical pathology, 69 6
Y. Kaneko, J. Rowley, D. Variakojis, R. Chilcote, J. Moohr, D. Patel (1981)
Chromosome abnormalities in Down's syndrome patients with acute leukemia.Blood, 58 3
(1984)
The Induction of Mitotic Aneuploidy , Point Mutation and Mitotic Crossing - over in Yeast Strains D 61 - M and D 6
W. Wissinger, D. Estervig, R. Wang (1981)
A differential staining technique for simultaneous visualization of mitotic spindle and chromosomes in mammalian cells.Stain technology, 56 4
D. Kelly, J. Parry (1983)
Metabolic activation of cytochrome P-450/P-448 in the yeast Saccharomyces cerevisiae.Mutation research, 108 1-3
(1976)
Hereditary factors in leukemia and lymphoma
G. Klein (1979)
Lymphoma development in mice and humans: diversity of initiation is followed by convergent cytogenetic evolution.Proceedings of the National Academy of Sciences of the United States of America, 76 5
K. Goh, H. Lee, G. Miller (1978)
Down's syndrome and leukemia: mechanism of additional chromosomal abnormalities.American journal of mental deficiency, 82 6
SummaryThree related assay systems have been developed for the detection and evaluation of chemicals capable of inducing mitotic chromosome aneuploidy. These assays, which involve the use of yeast and mammalian cell cultures, have been evaluated for their potential utility by the study of the aneugenic (aneuploidy-inducing) potential of a series of eight carcinogenic and two non-carcinogenic chemicals.The results of this study indicate that the assay of the potential of chemicals for their ability to induce cellular lesions which may lead to changes in chromosome number provides a valuable complement to the available in vitro assay systems for genotoxicity in that they are capable of detecting carcinogens that give negative results in bacterial mutagenicity assays.
Alternatives to Laboratory Animals – SAGE
Published: Mar 1, 1983
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