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FROM MEDICAL DEPARTMENT P, NEPHROLOGIC DIVISION, AND ROENTGENDIAGNOSTIC DEPARTMENT X, RIGSHOSPITALET, 2100 COPENHAGEN, DENMARK. HIGH-DOSE UROGRAPHY IN ADVANCED RENAL FAILURE II. Influence on renal and hepatic function N. MILMAN and P. STAGE A prerequisite for routine employment of high-dose urography in renal failure is reasonable atoxicity of the contrast medium, especially as regards the organs of excretion, i.e. the kidneys and liver. Reports dealing with the nephro- and hepatotoxicity of urographic contrast media in advanced renal failure and end-stage renal disease are not extensive. The present work was consequently aimed at renal and hepatic function in the periods before and following high-dose urography in this type of patient. Material and Methods. Renal and hepatic parameters were recorded in with the high-dose urographies described in the previous paper, the connection material being divided into four groups according to the duration of renal disease (STAGE et coll. 1973). From this material three patients had to be ex cluded; two because of a pre-urographic creatinine clearance of 0.0 ml/rnin and one by reason of insufficient recording of renal function. The material thus comprised 47 patients, all in advanced renal failure, with pre-urographic 24 hours endogenous creatinine clearance (= creatinine clearance) below 12.0
Acta Radiologica. Diagnosis – SAGE
Published: Aug 30, 2016
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