Access the full text.
Sign up today, get DeepDyve free for 14 days.
L. Thomas, C. Howard (1974)
Effect of Mycoplasma dispar, Mycoplasma bovirhinis, Acholeplasma laidlawii and T-mycoplasmas on explant cultures of bovine trachea.Journal of comparative pathology, 84 2
L. Mayr, P. Fuerst (2008)
The Future of High-Throughput ScreeningJournal of Biomolecular Screening, 13
Jungwoo Lee, Meghan Cuddihy, N. Kotov (2008)
Three-dimensional cell culture matrices: state of the art.Tissue engineering. Part B, Reviews, 14 1
Margaret Terzaghi, P. Nettesheim, M. Williams (1978)
Repopulation of denuded tracheal grafts with normal, preneoplastic, and neoplastic epithelial cell populations.Cancer research, 38 12
K. BéruBé, M. Aufderheide, D. Breheny, R. Clothier, R. Combes, R. Duffin, B. Forbes, M. Gaca, A. Gray, Ian Hall, Michael Kelly, M. Lethem, M. Liebsch, Leona Merolla, J. Morin, J. Seagrave, M. Swartz, T. Tetley, M. Umachandran (2009)
In vitro models of inhalation toxicity and disease. The report of a FRAME workshop.Alternatives to laboratory animals : ATLA, 37 1
Steven Gibb (2007)
Toxicity testing in the 21st century: a vision and a strategy.Reproductive toxicology, 25 1
M. Lutolf, M. Lutolf, J. Hubbell (2005)
Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineeringNature Biotechnology, 23
Y. Ke, B. Gerwin, S. Ruskie, A. Pfeifer, C. Harris, J. Lechner (1990)
Cell density governs the ability of human bronchial epithelial cells to recognize serum and transforming growth factor beta-1 as squamous differentiation-inducing agents.The American journal of pathology, 137 4
S. Ballard, A. Taylor (1994)
Bioelectric properties of proximal bronchiolar epithelium.The American journal of physiology, 267 1 Pt 1
G. Triana-Baltzer, Maria Babizki, M. Chan, Adam Wong, L. Aschenbrenner, Erin Campbell, Qi-Xiang Li, R. Chan, J. Peiris, J. Nicholls, F. Fang (2010)
DAS181, a sialidase fusion protein, protects human airway epithelium against influenza virus infection: an in vitro pharmacodynamic analysis.The Journal of antimicrobial chemotherapy, 65 2
Reen Wu, Gordon Sato, Mike Whitcutt (1986)
Developing differentiated epithelial cell cultures: airway epithelial cells.Fundamental and applied toxicology : official journal of the Society of Toxicology, 6 4
C. Grobstein (1953)
Morphogenetic Interaction between Embryonic Mouse Tissues separated by a Membrane FilterNature, 172
Hiroyuki Mochizuki, Akihiro Morikawa, K. Tokuyama, Takayoshi Kuroume, Anthony Chao (1994)
The effect of non-steroidal anti-inflammatory drugs on the electrical properties of cultured dog tracheal epithelial cells.European journal of pharmacology, 252 2
W. Minuth, R. Strehl, K. Schumacher (2005)
Concepts of Tissue Creation
Roland Roguet, H. Schaefer (1997)
Overview of in vitro cell culture technologies and pharmaco-toxicological applications.Toxicology in vitro : an international journal published in association with BIBRA, 11 5
B. Justice, N. Badr, R. Felder (2009)
3D cell culture opens new dimensions in cell-based assays.Drug discovery today, 14 1-2
W. Minuth, R. Strehl, K. Schumacher (2005)
Tissue Engineering: Essentials for Daily Laboratory Work
K. Adler, J. Schwarz, M. Whitcutt, R. Wu (1987)
A new chamber system for maintaining differentiated guinea pig respiratory epithelial cells between air and liquid phasesBioTechniques, 5
(2010)
Cell Biology: International Student Version, 6th edn, 860pp
S. Lane, H. Rippon, A. Bishop (2007)
Stem cells in lung repair and regeneration.Regenerative medicine, 2 4
John Engelhardt, Edward Allen, James Wilson (1991)
Reconstitution of tracheal grafts with a genetically modified epithelium.Proceedings of the National Academy of Sciences of the United States of America, 88 24
R. Steele, A. Preston, J. Johnson, J. Handler (1986)
Porous-bottom dishes for culture of polarized cells.The American journal of physiology, 251 1 Pt 1
E. Lantelme, L. Orlando, P. Porcedda, Valentina Turinetto, M. Marchi, A. Amoroso, S. Mantovani, C. Giachino (2008)
An in vitro model of T cell receptor revision in mature human CD8+ T cells.Molecular immunology, 45 2
R. Hubbard (2006)
The burden of lung diseaseThorax, 61
Handler Js, A. Preston, R. Steele (1984)
Factors affecting the differentiation of epithelial transport and responsiveness to hormones.Federation proceedings, 43 8
J. Lechner, I. McClendon, M. Laveck, A. Shamsuddin, C. Harris (1983)
Differential control by platelet factors of squamous differentiation in normal and malignant human bronchial epithelial cells.Cancer research, 43 12 Pt 1
Vinayak Goel, M. Accomazzo, A. Dileo, P. Meier, A. Pitt, M. Pluskal, R. Kaiser (1992)
Deadend Microfiltration: Applications, Design, and Cost
G. Jackson, Jennifer Bolmarcich, M. Klausner, P. Hayden (2010)
Timecourse Of TH2 Cytokine-Induced Goblet Cell Hyperplasia In The EpiAirway In Vitro Human Airway Model
R. Agu, Satyanarayana Valiveti, D. Earles, M. Klausner, P. Hayden, D. Wermeling, A. Stinchcomb (2004)
Intranasal Delivery of Recombinant Human Parathyroid Hormone [hPTH (1–34)], Teriparatide in RatsEndocrine Research, 30
A. Pitt, J. Gabriels, F. Badmington, J. Mcdowell, L. Gonzales, M. Waugh (1987)
Cell culture on a microscopically transparent microporous membraneBioTechniques, 5
A. Bishop, H. Rippon (2006)
Stem cells – potential for repairing damaged lungs and growing human lungs for transplantExpert Opinion on Biological Therapy, 6
K. BéruBé, Claire Gibson, C. Job, Z. Prytherch (2011)
Human lung tissue engineering: a critical tool for safer medicinesCell and Tissue Banking, 12
D. Pankajakshan, L. Krishnan (2009)
Design of fibrin matrix composition to enhance endothelial cell growth and extracellular matrix deposition for in vitro tissue engineering.Artificial organs, 33 1
S. Dunsmore, D. Rannels (1996)
Extracellular matrix biology in the lung.The American journal of physiology, 270 1 Pt 1
P. Zalewski, R. Ruffin (2008)
Apoptosis-regulatory factors as potential drug targets in the epithelium of normal and inflamed airways.Current molecular pharmacology, 1 1
D. Balharry, K. Sexton, K. BéruBé (2008)
An in vitro approach to assess the toxicity of inhaled tobacco smoke components: nicotine, cadmium, formaldehyde and urethane.Toxicology, 244 1
(2007)
Peptides and pegylated peptides as intranasal permeation enhancers: Comparison to small molecular excipients
O. Sedelnikova, A. Nakamura, O. Kovalchuk, Igor Koturbash, S. Mitchell, S. Marino, D. Brenner, W. Bonner (2007)
DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models.Cancer research, 67 9
S. Byers, M. Hadley, D. Djakiew, Martin Dym (1986)
Growth and characterization of polarized monolayers of epididymal epithelial cells and Sertoli cells in dual environment culture chambers.Journal of andrology, 7 1
Shu-Chih Chen, Kristine Eiting, Kunyuan Cui, A. Leonard, Daniel Morris, Ching-Yuan Li, K. Farber, A. Sileno, M. Houston, P. Johnson, S. Quay, H. Costantino (2006)
Therapeutic utility of a novel tight junction modulating peptide for enhancing intranasal drug delivery.Journal of pharmaceutical sciences, 95 6
J. Prins (2006)
Directive 2003/98/EC of the European Parliament and of the Council
R. Agu, Satyanarayana Valiveti, K. Paudel, M. Klausner, P. Hayden, A. Stinchcomb (2006)
Permeation of WIN 55,212‐2, a potent cannabinoid receptor agonist, across human tracheo‐bronchial tissue in vitro and rat nasal epithelium in vivoJournal of Pharmacy and Pharmacology, 58
K. Sexton, D. Balharry, K. BéruBé (2008)
Genomic biomarkers of pulmonary exposure to tobacco smoke componentsPharmacogenetics and Genomics, 18
E. Hill, T. Eling, P. Nettesheim (1998)
Differentiation dependency of eicosanoid enzyme expression in human tracheobronchial cells.Toxicology letters, 96-97
(2010)
Human Tissue Equivalents of Respiratory Epithelia: In Vitro Alternatives for Screening of Candidate Respiratory Drugs, 234pp
A. Leonard, A. Sileno, Conor MacEvilly, C. Foerder, S. Quay, H. Costantino (2005)
Development of a novel high-concentration galantamine formulation suitable for intranasal delivery.Journal of pharmaceutical sciences, 94 8
B. Gomperts, L. Kim, Scott Flaherty, B. Hackett (2007)
IL-13 regulates cilia loss and foxj1 expression in human airway epithelium.American journal of respiratory cell and molecular biology, 37 3
Laura Palermo, M. Porotto, C. Yokoyama, Samantha Palmer, B. Mungall, O. Greengard, S. Niewiesk, A. Moscona (2009)
Human Parainfluenza Virus Infection of the Airway Epithelium: Viral Hemagglutinin-Neuraminidase Regulates Fusion Protein Activation and Modulates InfectivityJournal of Virology, 83
L. Kaartinen, P. Nettesheim, K. Adler, S. Randell (1993)
Rat tracheal epithelial cell differentiation in vitroIn Vitro Cellular & Developmental Biology - Animal, 29
(2007)
The third dimension bridges the gap between cell culture and live tissueNature Reviews Molecular Cell Biology, 8
Manju Sharma, R. Schoop, J. Hudson (2010)
The efficacy of Echinacea in a 3‐D tissue model of human airway epitheliumPhytotherapy Research, 24
W. Martin, Chris Brown, Yao Zhang, R. Wu (1991)
Growth and differentiation of primary tracheal epithelial cells in culture: Regulation by extracellular calciumJournal of Cellular Physiology, 147
R. Freishtat, A. Watson, A. Benton, S. Iqbal, D. Pillai, M. Rose, E. Hoffman (2011)
Asthmatic airway epithelium is intrinsically inflammatory and mitotically dyssynchronous.American journal of respiratory cell and molecular biology, 44 6
Shu-Chih Chen-Quay, Kristine Eiting, Ang Li, N. Lamharzi, S. Quay (2009)
Identification of tight junction modulating lipids.Journal of pharmaceutical sciences, 98 2
A. Pitt (1987)
The nonspecific protein binding of polymeric microporous membranes.Journal of parenteral science and technology : a publication of the Parenteral Drug Association, 41 3
J. Guseh, Sam Bores, B. Stanger, Qiao Zhou, W. Anderson, D. Melton, J. Rajagopal (2009)
Notch signaling promotes airway mucous metaplasia and inhibits alveolar development, 136
A. Leonard, A. Sileno, G. Brandt, C. Foerder, S. Quay, H. Costantino (2007)
In vitro formulation optimization of intranasal galantamine leading to enhanced bioavailability and reduced emetic response in vivo.International journal of pharmaceutics, 335 1-2
K. BéruBé, D. Balharry, T. Jones, T. Moreno, P. Hayden, K. Sexton, M. Hicks, L. Merolla, C. Timblin, A. Shikla, B. Mossman (2006)
Characterisation of airborne particulate matter and related mechanisms of toxicity: an experimental approach
M. Kondo, W. Finkbeiner, J. Widdicombe (2007)
Cultures of bovine tracheal epithelium with differentiated ultrastructure and ion transportIn Vitro Cellular & Developmental Biology - Animal, 29
A. Watson, A. Benton, M. Rose, R. Freishtat (2010)
Cigarette Smoke Alters Tissue Inhibitor of Metalloproteinase 1 and Matrix Metalloproteinase 9 Levels in the Basolateral Secretions of Human Asthmatic Bronchial Epithelium In VitroJournal of Investigative Medicine, 58
M. Yamaya, Walter Finkbeiner, S. Chun, Jonathan Widdicombe (1992)
Differentiated structure and function of cultures from human tracheal epithelium.The American journal of physiology, 262 6 Pt 1
(1986)
Epithelial cell culture on a microporous membrane
T. Gray, K. Guzman, C. Davis, L. Abdullah, P. Nettesheim (1996)
Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cells.American journal of respiratory cell and molecular biology, 14 1
L. Agius (1987)
Human liver in vitro techniques for metabolic studies.Bailliere's clinical endocrinology and metabolism, 1 4
R. Babu, Pankaj Dayal, Mandip Singh (2008)
Effect of Cyclodextrins on the Complexation and Nasal Permeation of MelatoninDrug Delivery, 15
D. Knight, S. Holgate (2003)
The airway epithelium: Structural and functional properties in health and diseaseRespirology, 8
(2006)
Long term culture of pseudo-stratified tracheal bronchial EpiAirwayTM Tissues
Cell culture has long been a valuable tool for studying cell behaviour. Classical plastic substrates are two-dimensional, and usually promote cellular proliferation and inhibit differentiation. Understanding cell behaviour within complex multicellular tissues requires the systematic study of cells within the context of specific model microenvironments. A model system must mimic, to a certain degree, the in vivo situation, but, at the same time, can significantly reduce its complexity. There is increasing agreement that moving up to the third dimension provides a more physiologically-relevant and predictive model system. Moreover, many cellular processes (morphogenesis, organogenesis and pathogenesis) have been confirmed to occur exclusively when cells are ordered in a three-dimensional (3D) manner. In order to achieve the desired in vivo phenotype, researchers can use microporous membranes for improved in vitro cell culture experiments. In the present review, we discuss the applications of filter-well technology for the advanced 3-D cell culture of human pulmonary cells.
Alternatives to Laboratory Animals – SAGE
Published: Dec 1, 2010
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.