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Fifty Years after Russell and Burch, Toxicologists Continue to Ignore Genetic Variation in Their Test Animals

Fifty Years after Russell and Burch, Toxicologists Continue to Ignore Genetic Variation in Their... ATLA 37, 1–5, 2009 1 Editorial Fifty Years after Russell and Burch, Toxicologists Continue to Ignore Genetic Variation in Their Test Animals The Principles of Humane Experimental Tech - simple way in which scientists could substantially nique by Russell and Burch, published 50 years improve testing methods and pave the way for the ago this year, has had a major impact on the use of personalised medicine of the future, without using animals in biomedical research. The Three Rs: any more animals. They should control and iden- Replacement, Refinement and Reduction, provide a tify the genetic variation in the rats and mice used framework in which each animal experiment can in their experiments — something which they com- be ethically assessed. Could the results be obtained pletely fail to do at present. without using animals? If not, how can pain, suf- In their chapter on Reduction, Russell and fering and lasting harm be minimised in the pro- Burch note that the accuracy of an experiment posed experiment, and how can the number of “…depends on the size of the sample, the extent to animals used be reduced without loss of informa- which individuals of the species vary in response http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alternatives to Laboratory Animals SAGE

Fifty Years after Russell and Burch, Toxicologists Continue to Ignore Genetic Variation in Their Test Animals

Festing, Michael F.W.
Alternatives to Laboratory Animals , Volume 37 (1): 5 – Feb 1, 2009
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References (13)

Publisher
SAGE
Copyright
© 2009 Fund for the Replacement of Animals in Medical Experiments
ISSN
0261-1929
eISSN
2632-3559
DOI
10.1177/026119290903700101
Publisher site
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Abstract

ATLA 37, 1–5, 2009 1 Editorial Fifty Years after Russell and Burch, Toxicologists Continue to Ignore Genetic Variation in Their Test Animals The Principles of Humane Experimental Tech - simple way in which scientists could substantially nique by Russell and Burch, published 50 years improve testing methods and pave the way for the ago this year, has had a major impact on the use of personalised medicine of the future, without using animals in biomedical research. The Three Rs: any more animals. They should control and iden- Replacement, Refinement and Reduction, provide a tify the genetic variation in the rats and mice used framework in which each animal experiment can in their experiments — something which they com- be ethically assessed. Could the results be obtained pletely fail to do at present. without using animals? If not, how can pain, suf- In their chapter on Reduction, Russell and fering and lasting harm be minimised in the pro- Burch note that the accuracy of an experiment posed experiment, and how can the number of “…depends on the size of the sample, the extent to animals used be reduced without loss of informa- which individuals of the species vary in response

Journal

Alternatives to Laboratory Animals – SAGE

Published: Feb 1, 2009

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