Access the full text.
Sign up today, get DeepDyve free for 14 days.
A. Otsuka, Kenji Kabashima, Kenji Kabashima (2015)
Mast cells and basophils in cutaneous immune responsesAllergy, 70
D. Kaplan, B. Igyártó, A. Gaspari (2012)
Early immune events in the induction of allergic contact dermatitisNature Reviews Immunology, 12
(2015)
Genderrelated effects of sex steroids on histamine release and FcεRI expression in rat peritoneal mast cells
L. Facci, R. Toso, S. Romanello, A. Buriani, S. Skaper, A. Leon (1995)
Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide.Proceedings of the National Academy of Sciences of the United States of America, 92
Massimo Vaia, S. Petrosino, D. Filippis, L. Negro, A. Guarino, R. Carnuccio, V. Marzo, T. Iuvone (2016)
Palmitoylethanolamide reduces inflammation and itch in a mouse model of contact allergic dermatitis.European journal of pharmacology, 791
C. Río, C. Navarrete, J. Collado, M. Bellido, M. Gómez-Cañas, M. Pazos, J. Fernández-Ruiz, F. Pollastro, G. Appendino, M. Calzado, I. Cantarero, E. Muñoz (2016)
The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathwaysScientific Reports, 6
Alfredo Vannacci, Giovanni Zagli, C. Marzocca, S. Pierpaoli, M. Passani, P. Mannaioni, E. Masini (2002)
Down-regulation by cannabinoids of the immunological activation of human basophils and guinea pig mast cellsInflammation Research, 51
D. Filippis, A. D’Amico, T. Iuvone (2008)
Cannabinomimetic Control of Mast Cell Mediator Release: New Perspective in Chronic InflammationJournal of Neuroendocrinology, 20
M. Vocanson, A. Hennino, A. Rozieres, G. Poyet, Jean-François Nicolas (2009)
Effector and regulatory mechanisms in allergic contact dermatitisAllergy, 64
Eunsoo Jung, W. Jung, Su-Bin Park, Chan-Sik Kim, Jin Kim, Junghyun Kim (2017)
EGHB010, a Standardized Extract of Paeoniae Radix and Glycyrrhizae Radix, Inhibits VEGF-Induced Tube Formation In Vitro and Retinal Vascular Leakage and Choroidal Neovascularization In VivoEvidence-based Complementary and Alternative Medicine : eCAM, 2017
T. Rustemeyer (2022)
Immunological Mechanisms in Allergic Contact DermatitisCurrent Treatment Options in Allergy, 9
Slava Rom, Y. Persidsky (2013)
Cannabinoid Receptor 2: Potential Role in Immunomodulation and NeuroinflammationJournal of Neuroimmune Pharmacology, 8
Tangfeng Su, Ling-hong Zhang, M. Peng, Caihua Wu, Wen Pan, B. Tian, Jing Shi, H. Pan, Man Li (2011)
Cannabinoid CB2 Receptors Contribute to Upregulation of β-endorphin in Inflamed Skin Tissues by ElectroacupunctureMolecular Pain, 7
Stefan Martin (2015)
Immunological mechanisms in allergic contact dermatitisCurrent Opinion in Allergy and Clinical Immunology, 15
D. Gondim, J. Araújo, A. Cavalcante, A. Havt, J. Quetz, Gerly Brito, R. Ribeiro, Mariana Vale (2012)
CB1 and CB2 contribute to antinociceptive and anti-inflammatory effects of electroacupuncture on experimental arthritis of the rat temporomandibular joint.Canadian journal of physiology and pharmacology, 90 11
S. Muñoz-Cruz, Y. Mendoza-Rodríguez, K. Nava-Castro, L. Yépez-Mulia, J. Morales-Montor (2015)
Gender-Related Effects of Sex Steroids on Histamine Release and FcεRI Expression in Rat Peritoneal Mast CellsJournal of Immunology Research, 2015
Hyungwoo Kim, Miyoung Kim, Hanna Kim, Guemsan Lee, W. An, Suin Cho (2013)
Anti-inflammatory activities of Dictamnus dasycarpus Turcz., root bark on allergic contact dermatitis induced by dinitrofluorobenzene in mice.Journal of ethnopharmacology, 149 2
(2017)
Electroacupuncture at Zusanli acupoint (ST36) suppresses inflammation in allergic contact dermatitis via triggering local IL-10 production and inhibiting p38 MAPK activation
Zhigang Wang, T. Yi, Man Long, Yisen Gao, Chunhao Cao, Chenwei Huang, Qian Wang, Nina Yin, Zebin Chen (2017)
Electro-Acupuncture at Zusanli Acupoint (ST36) Suppresses Inflammation in Allergic Contact Dermatitis Via Triggering Local IL-10 Production and Inhibiting p38 MAPK ActivationInflammation, 40
Heng Zhou, Zhi Zhang, Haidong Wei, Feng Wang, F. Guo, Zijun Gao, G. Marsicano, Qiang Wang, L. Xiong (2013)
Activation of STAT3 is involved in neuroprotection by electroacupuncture pretreatment via cannabinoid CB1 receptors in ratsBrain Research, 1529
Maiko Kobayashi, S. Nunomura, Y. Gon, D. Endo, Sachiko Kishiro, Makiko Fukunaga, Yuko Kitahata, T. Terui, C. Ra (2010)
Abrogation of high-affinity IgE receptor-mediated mast cell activation at the effector phase prevents contact hypersensitivity to oxazolone.The Journal of investigative dermatology, 130 3
V. Giménez-Rivera, F. Siebenhaar, C. Zimmermann, H. Siiskonen, M. Metz, M. Maurer (2016)
Mast Cells Limit the Exacerbation of Chronic Allergic Contact Dermatitis in Response to Repeated Allergen ExposureThe Journal of Immunology, 197
L. Miller, L. Devi (2011)
The Highs and Lows of Cannabinoid Receptor Expression in Disease: Mechanisms and Their Therapeutic ImplicationsPharmacological Reviews, 63
Zhaoyu Liu, Xiyao Chen, Yang Gao, Sisi Sun, Lei Yang, Qianzi Yang, Fuhai Bai, L. Xiong, Qiang Wang (2015)
Involvement of GluR2 up-regulation in neuroprotection by electroacupuncture pretreatment via cannabinoid CB1 receptor in miceScientific Reports, 5
Masahiro Seike, K. Furuya, M. Omura, K. Hamada-Watanabe, A. Matsushita, Hiroshi Ohtsu (2010)
Histamine H4 receptor antagonist ameliorates chronic allergic contact dermatitis induced by repeated challengeAllergy, 65
L. Kostner, F. Anzengruber, C. Guillod, M. Recher, P. Schmid‐Grendelmeier, A. Navarini (2017)
Allergic Contact Dermatitis.Immunology and allergy clinics of North America, 37 1
Hui Zhang, Shengdong He, You-ping Hu, Hui-E Zheng (2016)
Antagonism of Cannabinoid Receptor 1 Attenuates the Anti-Inflammatory Effects of Electroacupuncture in a Rodent Model of MigraineAcupuncture in Medicine, 34
Hyung-Sik Kim, J. Yun, Tae-Hoon Shin, Sung‐Hoon Lee, Byung-Chul Lee, Kyung-Rok Yu, Yoojin Seo, Seunghee Lee, Tae-Wook Kang, S. Choi, K. Seo, Kyung‐Sun Kang (2015)
Human Umbilical Cord Blood Mesenchymal Stem Cell‐Derived PGE2 and TGF‐β1 Alleviate Atopic Dermatitis by Reducing Mast Cell DegranulationSTEM CELLS, 33
D. Mayor (2013)
An Exploratory Review of the Electroacupuncture Literature: Clinical Applications and Endorphin MechanismsAcupuncture in Medicine, 31
J. Fowler (2011)
Histamine H4 receptor antagonist ameliorates chronic allergic contact dermatitis induced by repeated challengeYearbook of Dermatology and Dermatologic Surgery, 2011
K. Livak, Thomas Schmittgen (2001)
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.Methods, 25 4
Sharon Jung, Haim Song, Yu Kim, Jungdae Kim, Sungchul Kim, Y. Song, K. Soh (2017)
Distribution of Mast Cells and Locations, Depths, and Sizes of the Putative Acupoints CV 8 and KI 16Evidence-based Complementary and Alternative Medicine : eCAM, 2017
M. Karsak, E. Gaffal, Rahul Date, Lihua Wang-Eckhardt, J. Rehnelt, S. Petrosino, K. Starowicz, Regina Steuder, E. Schlicker, B. Cravatt, R. Mechoulam, R. Buettner, S. Werner, V. Marzo, T. Tüting, A. Zimmer (2007)
Attenuation of Allergic Contact Dermatitis Through the Endocannabinoid SystemScience, 316
Objective:Cannabinoid CB2 receptors (CB2Rs) are mainly present on immune cells including mast cells, which participate in 2,4-dinitrofluorobenzene (DNFB)-induced allergic contact dermatitis (ACD). In this study, we aimed to investigate whether inhibition of mast cell degranulation was involved in the anti-ACD effect of electroacupuncture (EA) at ST36 via CB2R.Methods:Sprague-Dawley rats were sensitised and challenged with DNFB following EA stimulation for 1 week. Ear swelling, serum IgE levels, local cytokine production and mast cell infiltration were evaluated. Additionally, rat peritoneal mast cells (RPMCs) were isolated and cultured for detection of CB2R expression, mitogen-activated protein kinase (MAPK) signalling activation and mast cell degranulation (including β-hexosaminidase and histamine release) in the presence or absence of CB2R antagonists.Results:EA treatment inhibited ear swelling, suppressed IgE and cytokine production, decreased the number of mast cells and curbed mast cell degranulation, which was associated with the inhibition of p38 phosphorylation in DNFB-induced ACD. Importantly, EA enhanced the expression of CB2R mRNA and protein in the RPMCs. CB2R antagonist AM630 but not CB1R antagonist AM251 effectively reversed the suppressive effect of EA on p38 activation, mast cell infiltration and degranulation.Conclusion:These findings provide more evidence to support the hypothesis that EA promotes CB2R expression in mast cells, which is followed by inhibition of the p38 MAPK pathway, potentially resulting in the anti-ACD effect of EA. This suggests that EA at ST36 may be an effective candidate therapy for treating inflammatory skin diseases such as ACD.
Acupuncture in Medicine – SAGE
Published: Dec 1, 2019
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.