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ATLA 27, 221–223, 1999 221 discomfort or pain, and it is recognised that Prevalidation of In n Vitro Tests for Acute the response in the rabbit is not always pre- Skin Irritation dictive of that found in humans. For these rea- sons, the prediction of chemically induced Following the successful validation of two in acute dermal irritation is an area in which vitro methods for skin corrosivity testing, a considerable effort has been directed toward prevalidation study on alternative methods for the development and evaluation of alternative skin irritation testing is being supported by test methods in recent years. ECVAM during 1999–2000. The main objective As a follow-up to the successful validation of of the validation activities is to identify those two alternative tests for skin corrosivity, the in vitro tests capable of discriminating skin ECVAM Skin Irritation Task Force recognised irritants (I) from non-irritants (NI), as the urgent need to make progress in validating defined according to European Union (EU) relevant in vitro tests for acute skin irrita- risk phrases (R38; no label) and the har- tion. Following review of protocols and data monised OECD criteria (Irritant; no label). The TM submitted to this task force by test
Alternatives to Laboratory Animals – SAGE
Published: Mar 1, 1999
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