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The Southampton group (from left to right), Emma Bishop, Marianna Roman Zantl of ibidi GmbH. Gaça, Fiona Cunningham, Oluwatobiloba Oke, Natalia Cockcroft and Ian Fearon. The 2009 Dorothy Hegarty Award has been won by Natalia Cockcroft, Oluwatobiloba Oke, Fiona Cunningham, Emma Bishop, Ian Fearon, and Marianna Gaça (all from British American Tobacco, Southampton, UK) and Roman Zantl (from ibidi GmbH, Martinsried, Germany), for their paper, An In Vitro Perfusion System to Examine the Responses of Endothelial Cells to Simulated Flow and Inflammatory Stimulation (ATLA 37, 657–669). The Award is presented annually to the author(s) of the paper published in the previous year’s volume of FRAME’s scientific journal, ATLA, which, in the opinion of the members of the Editorial Board, is likely to make the most significant contribution to the reduction, refinement and/or replacement of animal experimentation. Each member of the ATLA Editorial Board is entitled to make up to five nominations for the Award, in rank order. As in previous years, a large variety of papers were nominated, reflecting the diversity of the work published in ATLA, and the wide range of interests of the members of the Editorial Board. The lead author has recently provided an update on the progress of the important work presented in the 2009 paper: “Since we published the development of the perfusion system in ATLA, we have been fur- ther refining the monocyte adhesion assay in particular, and testing the responsiveness of this assay to both particulate and vapour phase cigarette smoke extracts. With this infor- mation, next year we will begin an internal validation, in which we will examine the repro- ducibility of data obtained using the assay. Following on from this, we will potentially use the assay as part of our process for testing reduced toxicant prototypes, and we are very excited about integrating such a physiologically-relevant system into our product assess- ment framework.”
Alternatives to Laboratory Animals – SAGE
Published: Aug 1, 2010
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