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References (6)
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- Publisher
- SAGE
- Copyright
- © 1988 Fund for the Replacement of Animals in Medical Experiments
- ISSN
- 0261-1929
- eISSN
- 2632-3559
- DOI
- 10.1177/026119298801500308
- Publisher site
- See Article on Publisher Site
Abstract
A roller incubation procedure was used to co-cultivate primary cultures of chick hepatocytes with a human fibroblast-like cell line (HFB). When HFB cells alone were incubated, in the presence of allyl alcohol, an increased rate of protein synthesis was observed. In the hepatocyte-fibroblast co-cultures, allyl alcohol caused a dose-dependent decrease in the rate of protein synthesis in the cells of both types. This effect was much more pronounced in the hepatocytes. It was concluded that in the co-cultures allyl alcohol was oxidised to acrolein, which exerted its toxic action primarily on the hepatic cells.
Journal
Alternatives to Laboratory Animals – SAGE
Published: Mar 1, 1988