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T. Hardingham (2010)
Fell‐Muir Lecture: Cartilage 2010 – The Known UnknownsInternational Journal of Experimental Pathology, 91
Christopher Brew, Peter Clegg, Ray Boot-Handford, J. Andrew, T. Hardingham (2008)
Gene expression in human chondrocytes in late osteoarthritis is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophyAnnals of the Rheumatic Diseases, 69
A. Murdoch, Lisa Grady, Matthew Ablett, T. Katopodi, R. Meadows, T. Hardingham (2007)
Chondrogenic Differentiation of Human Bone Marrow Stem Cells in Transwell Cultures: Generation of Scaffold‐Free CartilageSTEM CELLS, 25
S. Tew, T. Hardingham (2006)
Regulation of SOX9 mRNA in Human Articular Chondrocytes Involving p38 MAPK Activation and mRNA Stabilization*Journal of Biological Chemistry, 281
T. Hardingham (2008)
Extracellular matrix and pathogenic mechanisms in osteoarthritisCurrent Rheumatology Reports, 10
S. Abramson, M. Attur (2009)
Developments in the scientific understanding of osteoarthritisArthritis Research & Therapy, 11
A. Bay‐Jensen, Suzi Hoegh-Madsen, E. Dam, K. Henriksen, B. Sondergaard, P. Pastoureau, P. Qvist, M. Karsdal (2010)
Which elements are involved in reversible and irreversible cartilage degradation in osteoarthritis?Rheumatology International, 30
T. Hardingham (1979)
The role of link-protein in the structure of cartilage proteoglycan aggregates.The Biochemical journal, 177 1
Rachel Oldershaw, T. Hardingham (2010)
Notch signaling during chondrogenesis of human bone marrow stem cells.Bone, 46 2
Y. Li, S. Tew, A. Russell, K. Gonzalez, T. Hardingham, R. Hawkins (2004)
Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9.Tissue engineering, 10 3-4
Rachel Oldershaw, S. Tew, A. Russell, K. Meade, Robert Hawkins, T. McKay, K. Brennan, T. Hardingham (2008)
Notch Signaling Through Jagged‐1 Is Necessary to Initiate Chondrogenesis in Human Bone Marrow Stromal Cells but Must Be Switched off to Complete ChondrogenesisSTEM CELLS, 26
Aurélie Moreau, M. Hill, M. Hill, Pamela Thebault, Pamela Thebault, J. Deschamps, Elise Chiffoleau, Elise Chiffoleau, C. Chauveau, C. Chauveau, P. Moullier, Ignacio Anegon, Ignacio Anegon, Brigitte Alliot-Licht, Brigitte Alliot-Licht, M. Cuturi, M. Cuturi (2009)
Tolerogenic dendritic cells actively inhibit T cells through heme oxygenase‐1 in rodents and in nonhuman primatesThe FASEB Journal, 23
T. Hardingham, H. Muir (1972)
The specific interaction of hyaluronic acid with cartillage proteoglycans.Biochimica et biophysica acta, 279 2
S. Tew, Y. Li, P. Pothacharoen, Lisa Tweats, R. Hawkins, T. Hardingham (2005)
Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes.Osteoarthritis and cartilage, 13 1
B. Johnstone, T. Hering, A. Caplan, V. Goldberg, J. Yoo (1998)
In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells.Experimental cell research, 238 1
D. Phinney (2008)
Marrow Stem Cells
S. Tew, A. Murdoch, Richard Rauchenberg, T. Hardingham (2008)
Cellular methods in cartilage research: primary human chondrocytes in culture and chondrogenesis in human bone marrow stem cells.Methods, 45 1
M. Pittenger, A. Mackay, S. Beck, R. Jaiswal, Robin Douglas, J. Mosca, M. Moorman, D. Simonetti, S. Craig, D. Marshak (1999)
Multilineage potential of adult human mesenchymal stem cells.Science, 284 5411
T. Hardingham, A. Fosang (1992)
Proteoglycans: many forms and many functionsThe FASEB Journal, 6
Damage and degeneration of articular joints is a major healthcare concern, due to the association of joint disease with ageing, the current strong demographic changes in the proportion of elderly in the population, and the increased incidence of trauma in a sports-active younger population. These joints are biomechanical organs that transmit load between bones in our skeleton, and the articular cartilage forms a load-bearing surface that covers the bone within the joints. All the forces across the joints are thus transmitted through the cartilage, and it therefore makes an important biomechanical contribution to joint function. The cartilage is particularly prone to damage, and has limited capacity for natural repair. Although joint replacement is successful, it is less so in younger patients. For these patients, there is currently great interest in developing cell-based treatments for the biological repair of articular cartilage.
Alternatives to Laboratory Animals – SAGE
Published: Dec 1, 2010
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