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Cell- and Tissue-Based Approaches for Cartilage Repair

Cell- and Tissue-Based Approaches for Cartilage Repair Damage and degeneration of articular joints is a major healthcare concern, due to the association of joint disease with ageing, the current strong demographic changes in the proportion of elderly in the population, and the increased incidence of trauma in a sports-active younger population. These joints are biomechanical organs that transmit load between bones in our skeleton, and the articular cartilage forms a load-bearing surface that covers the bone within the joints. All the forces across the joints are thus transmitted through the cartilage, and it therefore makes an important biomechanical contribution to joint function. The cartilage is particularly prone to damage, and has limited capacity for natural repair. Although joint replacement is successful, it is less so in younger patients. For these patients, there is currently great interest in developing cell-based treatments for the biological repair of articular cartilage. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alternatives to Laboratory Animals SAGE

Cell- and Tissue-Based Approaches for Cartilage Repair

Alternatives to Laboratory Animals , Volume 38 (1_suppl): 5 – Dec 1, 2010

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References (19)

Publisher
SAGE
Copyright
© 2010 Fund for the Replacement of Animals in Medical Experiments
ISSN
0261-1929
eISSN
2632-3559
DOI
10.1177/026119291003801S10
Publisher site
See Article on Publisher Site

Abstract

Damage and degeneration of articular joints is a major healthcare concern, due to the association of joint disease with ageing, the current strong demographic changes in the proportion of elderly in the population, and the increased incidence of trauma in a sports-active younger population. These joints are biomechanical organs that transmit load between bones in our skeleton, and the articular cartilage forms a load-bearing surface that covers the bone within the joints. All the forces across the joints are thus transmitted through the cartilage, and it therefore makes an important biomechanical contribution to joint function. The cartilage is particularly prone to damage, and has limited capacity for natural repair. Although joint replacement is successful, it is less so in younger patients. For these patients, there is currently great interest in developing cell-based treatments for the biological repair of articular cartilage.

Journal

Alternatives to Laboratory AnimalsSAGE

Published: Dec 1, 2010

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