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Book Review: Worse than the Disease

Book Review: Worse than the Disease ATLA 17 131-132 1989 131 from a quantitative point of view, then long-term toxicity can be predicted. How we wish that this were true! I would have thought that instead of proliferating tests of doubtful value, those engaged in mutation research should look to new endpoints more specifically related to known mechanisms of cancer induction. To be fair to Dr Vos, he did caution against introducing tests for immunogenicity into the toxicological repertoire without careful validation. Kinetic monitoring during the course of toxicity studies is helpful; if the quantitative exposure of animals in toxicity studies is unknown, it is impossible to make valid interpretation or extrapolate the data to man. The benefits and the limitations of kinetic monitoring should have been spelled out and some attempt made to show how these data can be applied to RISK ASSESSMENT- THE COMMON long-term toxicity and reproductive studies. GROUND As a publicity and marketing exercise, the Proceedings of Life Science Symposium 9 symposium must have been an unqualified success; Editor-in-Chief: Colin N. Roberts it must have contributed to the bottom line of the Life Science Research, 1989 company's accounts and so to the Queen's Award xix + 185 pp. for export achievement, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alternatives to Laboratory Animals SAGE

Book Review: Worse than the Disease

Ungar, Krystyna
Alternatives to Laboratory Animals , Volume 17 (2): 2 – Dec 1, 1989
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Publisher
SAGE
Copyright
© 1989 Fund for the Replacement of Animals in Medical Experiments
ISSN
0261-1929
eISSN
2632-3559
DOI
10.1177/026119298901700211
Publisher site
See Article on Publisher Site

Abstract

ATLA 17 131-132 1989 131 from a quantitative point of view, then long-term toxicity can be predicted. How we wish that this were true! I would have thought that instead of proliferating tests of doubtful value, those engaged in mutation research should look to new endpoints more specifically related to known mechanisms of cancer induction. To be fair to Dr Vos, he did caution against introducing tests for immunogenicity into the toxicological repertoire without careful validation. Kinetic monitoring during the course of toxicity studies is helpful; if the quantitative exposure of animals in toxicity studies is unknown, it is impossible to make valid interpretation or extrapolate the data to man. The benefits and the limitations of kinetic monitoring should have been spelled out and some attempt made to show how these data can be applied to RISK ASSESSMENT- THE COMMON long-term toxicity and reproductive studies. GROUND As a publicity and marketing exercise, the Proceedings of Life Science Symposium 9 symposium must have been an unqualified success; Editor-in-Chief: Colin N. Roberts it must have contributed to the bottom line of the Life Science Research, 1989 company's accounts and so to the Queen's Award xix + 185 pp. for export achievement,

Journal

Alternatives to Laboratory Animals – SAGE

Published: Dec 1, 1989

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