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Book Review: The Use of Animals in Research Related to Epilepsy and Other Disorders in Which Convulsions May Occur

Book Review: The Use of Animals in Research Related to Epilepsy and Other Disorders in Which... ATLA 17,44-48, 1989 44 consuming to use them for drug evaluation. Certain baboons, fowl, mice, rats and gerbils have fits in response to light, sound or handling, while in other animal models, convulsions are induced by a variety of methods, e.g. electrical stimulation of the brain, injection of convulsant chemicals or application of chemicals to the brain. These models are preferred, because convulsions can be induced at the experimenter's will. The animal models known to be used in the UK are described in detail. There are problems inherent in using animal models, particularly those in which single seizures are induced by chemicals or electroshock. True epilepsy is a pattern of recurrent, spontaneous seizures, mostly correlated with characteristic EEG abnormalities, often age-dependent, and associated with various other symptoms, depending on the type of epilepsy. Animal models do not reproduce THE USE OF ANIMALS IN RESEARCH these patterns, although attempts are being made RELATED TO EPILEPSY AND OTHER (by injection of chemicals into the brain) to create DISORDERS IN WHICH states of chronic seizure. CONVULSIONS MAY OCCUR It is possible to obtain useful information on anti­ Sheila Silcock convulsant drug activity, and on the chemical and RSPCA,1989 electrical patterns associated with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alternatives to Laboratory Animals SAGE

Book Review: The Use of Animals in Research Related to Epilepsy and Other Disorders in Which Convulsions May Occur

Griffin, Gilly
Alternatives to Laboratory Animals , Volume 17 (1): 2 – Sep 1, 1989
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Publisher
SAGE
Copyright
© 1989 Fund for the Replacement of Animals in Medical Experiments
ISSN
0261-1929
eISSN
2632-3559
DOI
10.1177/026119298901700111
Publisher site
See Article on Publisher Site

Abstract

ATLA 17,44-48, 1989 44 consuming to use them for drug evaluation. Certain baboons, fowl, mice, rats and gerbils have fits in response to light, sound or handling, while in other animal models, convulsions are induced by a variety of methods, e.g. electrical stimulation of the brain, injection of convulsant chemicals or application of chemicals to the brain. These models are preferred, because convulsions can be induced at the experimenter's will. The animal models known to be used in the UK are described in detail. There are problems inherent in using animal models, particularly those in which single seizures are induced by chemicals or electroshock. True epilepsy is a pattern of recurrent, spontaneous seizures, mostly correlated with characteristic EEG abnormalities, often age-dependent, and associated with various other symptoms, depending on the type of epilepsy. Animal models do not reproduce THE USE OF ANIMALS IN RESEARCH these patterns, although attempts are being made RELATED TO EPILEPSY AND OTHER (by injection of chemicals into the brain) to create DISORDERS IN WHICH states of chronic seizure. CONVULSIONS MAY OCCUR It is possible to obtain useful information on anti­ Sheila Silcock convulsant drug activity, and on the chemical and RSPCA,1989 electrical patterns associated with

Journal

Alternatives to Laboratory Animals – SAGE

Published: Sep 1, 1989

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