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Book Review: The Future of Predictive Safety Evaluation

Book Review: The Future of Predictive Safety Evaluation ATLA 15 4-w51 1987 44 intervention with modern drugs is on the whole remarkably safe. He lists four barriers to progress in further reducing risk: confidentiality (in doctor­ patient relationships), misconceptions (e.g. that all drugs could ever be completely safe), litigation (good for lawyers, but not for drug-damaged patients), and premature publication (of possible problems with drugs-drug companies get sued for harming hundreds, but not investigative journalists who can destroy confidence in valuable drugs and thus harm thousands). W. Howe, M.D. Stanard & B.H. Woollen (ICI) emphasise the need for volunteer human studies, with the chemical industry workforce in mind, since "only tentative reliance can be placed on predictions of human response which depend exclusively on animal toxicology studies" -''the THE FUTURE OF PREDICTIVE ultimate assessment of actual risk in exposed individuals must depend on the absorption of a SAFETY EVALUATION Edited by Alastair N. Worden, Dennis V. Parke & chemical and the demonstration of the resultant response in man". They foresee the development of John Marks MTP Press, Lancaster, several new techniques for safely investigating Vol. I, x + 227 pp. £35.00 what happens in human beings. G. Teeling Smith (Office of Health Economics, ISBN 0-85200-873-2 London) then http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alternatives to Laboratory Animals SAGE

Book Review: The Future of Predictive Safety Evaluation

Alternatives to Laboratory Animals , Volume 15 (1): 2 – Sep 1, 1987

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Publisher
SAGE
Copyright
© 1987 Fund for the Replacement of Animals in Medical Experiments
ISSN
0261-1929
eISSN
2632-3559
DOI
10.1177/026119298701500112
Publisher site
See Article on Publisher Site

Abstract

ATLA 15 4-w51 1987 44 intervention with modern drugs is on the whole remarkably safe. He lists four barriers to progress in further reducing risk: confidentiality (in doctor­ patient relationships), misconceptions (e.g. that all drugs could ever be completely safe), litigation (good for lawyers, but not for drug-damaged patients), and premature publication (of possible problems with drugs-drug companies get sued for harming hundreds, but not investigative journalists who can destroy confidence in valuable drugs and thus harm thousands). W. Howe, M.D. Stanard & B.H. Woollen (ICI) emphasise the need for volunteer human studies, with the chemical industry workforce in mind, since "only tentative reliance can be placed on predictions of human response which depend exclusively on animal toxicology studies" -''the THE FUTURE OF PREDICTIVE ultimate assessment of actual risk in exposed individuals must depend on the absorption of a SAFETY EVALUATION Edited by Alastair N. Worden, Dennis V. Parke & chemical and the demonstration of the resultant response in man". They foresee the development of John Marks MTP Press, Lancaster, several new techniques for safely investigating Vol. I, x + 227 pp. £35.00 what happens in human beings. G. Teeling Smith (Office of Health Economics, ISBN 0-85200-873-2 London) then

Journal

Alternatives to Laboratory AnimalsSAGE

Published: Sep 1, 1987

There are no references for this article.