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ATLA 22, 56-57, 1994 Book Reviews--- PROGRESS IN CLINICAL AND action of a compound, or the fact that interspecies BIOLOGICAL RESEARCH variation exists. For example, Neil Johnson's paper' highlights how animal inhalation studies have been Volume 374: Relevance of Animal a poor model for predicting that crocidolite, erionite Studies to the Evaluation of Human and glass fibres would all be carcinogenic, whilst, Cancer Risk as yet, there is no evidence of carcinogenicity of Edited by Robert D'Amato, Thomas J. Salga, glass fibres in man. Nevertheless, these studies William H. Farland & Carol Henry have highlighted details in their mode of action, Wiley-Liss, NY, USA the relevance of fibre length, fibre clumping and 482 pp., £98.00/US$147.00 surface chemistry. Studies of benzene metabolism ISBN 0-471-56183-5 further highlight what a poor model the rat is for This book contains the proceedings of a symposium man, with tumours not only arising in different with the same title, held in Texas, USA, in organs to those found in man, but also from December 1990. Like all meeting proceedings, the different embryonic tissues and showing totally quality of the individual contributions varies disparate dose-response relationships. considerably, from the clear and relevant to those The sections
Alternatives to Laboratory Animals – SAGE
Published: Jan 1, 1994
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