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Book Review: Biotransformations Volume III

Book Review: Biotransformations Volume III ATLA 19 362-364 1991 362 Book Reviews--- Use of Animals; Use of Animals for Safety Reasons· BIOTRANSFORMATIONS Volume III and The Future of Animal Research. ' Edited by David R. Hawkins The greater part of the book is devoted to Royal Society of Chemistry, 1991 disc';lssion of the role of animal experiments in 464 pp., £89.50 medJCal research. The 12 papers in this section are ISBN 0 85186 177 6 of. interes~ in their own right, as non-specialist bnefings m areas of current research activity. I This series continues to fulfil a very useful role. I particularly enjoyed the contribution from Zoja et am sure that the two previous volumes have been al. (Italy), as a gripping story of progress in widely used; certainly, my copies have been understanding human kidney disease. Other invaluable in my teaching and research. The papers consi~er the ~ole of animal experiments in present volume presents data published on pharmacological bram research, studies on the biotransformations of xenobiotics during 1989, and regeneration of the nervous system the indices are cumulative for the first three neuroend~crinology, cardiovascular pathology: volumes. The authors are to be congratulated on hypertensiOn research, thrombosis research producing a uniformly high standard of tumour immunology, cancer chemotherapy' presentation for each report. The net seems to have transpla!ltation research, AIDS research, and drug been spread very wide, including as it does reports and vaccme development against tropical diseases. of metabolism in fungi, house flies, zebra fish, Most of these contributions draw out the bovine nasal olfactory mucosa, and man, among ~ifficulty of us.ing in vitro methods to study others! mtegrated physiOlogical systems, and some show Dr Hawkins, in his Preface, rightly draws clearly the interdependence of in vitro and in vivo attention to the need to collate information on studies. Few, however, engage in significant critical biotransformations to recognise patterns of discussion. of the use o~ animals. The papers on biotransformation related to chemical structure. hyp~rtens10n, thrombosis, tumour immunology, Certainly, the concept of "key functional groups" cardiovascular pathology and AIDS include some that is used in this series is a valuable tool in this consideration of the limitations of particular animal respect, and one imagines that the data published "models", but, throughout the section, there is little in Biotransformations will soon be available on a mention of possibilities for reducing and/or refining computer database, with the facility to enter the their current use. structure of a novel xenobiotic into the program Notable exceptions come from T.A. Connors and then search the library for possible reactions (UK), and J. Sassard (France). Connors describes at the key functional groups, and perhaps identify some of the drawbacks of screening compounds for preferred routes in particular species. anticancer activity using animals, and discusses the de~e_lopment of in vitro systems. Whilst Jeffrey R. Fry emphasising that further progress in cancer chemotherapy will depend on some use of animals (particularly tumour-bearing rodents) Connors predicts that if the new in vitro sy~tems are successful, the use of animals in empirical THE IMPORTANCE OF ANIMAL screening could be considerably reduced. EXPERIMENTATION FOR SAFETY Furthermore, he argues, there is sufficient past AND BIOMEDICAL RESEARCH experience in testing anticancer agents for toxicity Edited by S. Garattini and D.W. van Bekkum to suggest that there is no need for pre-clinical Kluwer Academic Publishers, 1990 toxicological data on mammals other than rodents 252 pp., £54.50/Dfl. 155.00 and "higher" mammals such as dogs should n~ longer be used in such studies. Sassard, writing on ISBN 0 7923 0514 0 the use of animals in cardiovascular pathology This book is a collection of papers presented at an argues that animal experiments are "absolutely international symposium held in Strasbourg in essential" in this research, but nevertheless October 1988. The stated aim of the symposium concedes that it is "methodologically possible and was to assess the "requirement" for animal-based ethically imperative" to reduce and refine the use research in "solving major medical and toxicological of animals, by developing more appropriate animal problems". There are contributions from workers "models", and improving the number and quality in France, Germany, Italy, the Netherlands, of the parameters measured in each animal. Sweden, Switzerland, the UK and the USA. The Sassard gives a number of examples of how this book is divided into four sections: Ethical and Legal could be achieved. It seems a shame that, in a Aspects; Recent Progress of Medicine Requiring the collection of papers specifically about the use of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alternatives to Laboratory Animals SAGE

Book Review: Biotransformations Volume III

Fry, Jeffrey R.
Alternatives to Laboratory Animals , Volume 19 (3): 1 – Jul 1, 1991
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Publisher
SAGE
Copyright
© 1991 Fund for the Replacement of Animals in Medical Experiments
ISSN
0261-1929
eISSN
2632-3559
DOI
10.1177/026119299101900310
Publisher site
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Abstract

ATLA 19 362-364 1991 362 Book Reviews--- Use of Animals; Use of Animals for Safety Reasons· BIOTRANSFORMATIONS Volume III and The Future of Animal Research. ' Edited by David R. Hawkins The greater part of the book is devoted to Royal Society of Chemistry, 1991 disc';lssion of the role of animal experiments in 464 pp., £89.50 medJCal research. The 12 papers in this section are ISBN 0 85186 177 6 of. interes~ in their own right, as non-specialist bnefings m areas of current research activity. I This series continues to fulfil a very useful role. I particularly enjoyed the contribution from Zoja et am sure that the two previous volumes have been al. (Italy), as a gripping story of progress in widely used; certainly, my copies have been understanding human kidney disease. Other invaluable in my teaching and research. The papers consi~er the ~ole of animal experiments in present volume presents data published on pharmacological bram research, studies on the biotransformations of xenobiotics during 1989, and regeneration of the nervous system the indices are cumulative for the first three neuroend~crinology, cardiovascular pathology: volumes. The authors are to be congratulated on hypertensiOn research, thrombosis research producing a uniformly high standard of tumour immunology, cancer chemotherapy' presentation for each report. The net seems to have transpla!ltation research, AIDS research, and drug been spread very wide, including as it does reports and vaccme development against tropical diseases. of metabolism in fungi, house flies, zebra fish, Most of these contributions draw out the bovine nasal olfactory mucosa, and man, among ~ifficulty of us.ing in vitro methods to study others! mtegrated physiOlogical systems, and some show Dr Hawkins, in his Preface, rightly draws clearly the interdependence of in vitro and in vivo attention to the need to collate information on studies. Few, however, engage in significant critical biotransformations to recognise patterns of discussion. of the use o~ animals. The papers on biotransformation related to chemical structure. hyp~rtens10n, thrombosis, tumour immunology, Certainly, the concept of "key functional groups" cardiovascular pathology and AIDS include some that is used in this series is a valuable tool in this consideration of the limitations of particular animal respect, and one imagines that the data published "models", but, throughout the section, there is little in Biotransformations will soon be available on a mention of possibilities for reducing and/or refining computer database, with the facility to enter the their current use. structure of a novel xenobiotic into the program Notable exceptions come from T.A. Connors and then search the library for possible reactions (UK), and J. Sassard (France). Connors describes at the key functional groups, and perhaps identify some of the drawbacks of screening compounds for preferred routes in particular species. anticancer activity using animals, and discusses the de~e_lopment of in vitro systems. Whilst Jeffrey R. Fry emphasising that further progress in cancer chemotherapy will depend on some use of animals (particularly tumour-bearing rodents) Connors predicts that if the new in vitro sy~tems are successful, the use of animals in empirical THE IMPORTANCE OF ANIMAL screening could be considerably reduced. EXPERIMENTATION FOR SAFETY Furthermore, he argues, there is sufficient past AND BIOMEDICAL RESEARCH experience in testing anticancer agents for toxicity Edited by S. Garattini and D.W. van Bekkum to suggest that there is no need for pre-clinical Kluwer Academic Publishers, 1990 toxicological data on mammals other than rodents 252 pp., £54.50/Dfl. 155.00 and "higher" mammals such as dogs should n~ longer be used in such studies. Sassard, writing on ISBN 0 7923 0514 0 the use of animals in cardiovascular pathology This book is a collection of papers presented at an argues that animal experiments are "absolutely international symposium held in Strasbourg in essential" in this research, but nevertheless October 1988. The stated aim of the symposium concedes that it is "methodologically possible and was to assess the "requirement" for animal-based ethically imperative" to reduce and refine the use research in "solving major medical and toxicological of animals, by developing more appropriate animal problems". There are contributions from workers "models", and improving the number and quality in France, Germany, Italy, the Netherlands, of the parameters measured in each animal. Sweden, Switzerland, the UK and the USA. The Sassard gives a number of examples of how this book is divided into four sections: Ethical and Legal could be achieved. It seems a shame that, in a Aspects; Recent Progress of Medicine Requiring the collection of papers specifically about the use of

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Alternatives to Laboratory Animals – SAGE

Published: Jul 1, 1991

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