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Book Review: Biomedical Research Involving Animals

Book Review: Biomedical Research Involving Animals BOOK REVIEWS propagation impinge upon the commercial REPRODUCTIVE AND application of this subject. The use of DEVELOPMENTAL TOXICITY OF undifferentiated tissues to assess the physiological METALS activity of exogenously supplied growth regulators Edited by Thomas W. Clarkson, Gunnar F. is also considered. This approach, using plant Nordberg & Polly R. Sager cultures, could be extended to assessments of the Plenum Press, NY,1983 general toxicity of drugs, pesticides, and other xviii + 845 pp. $115.00 chemicals. Extrapolation of such results to animal ISBN 0-306-41396-5 cells could reduce the necessity for live animal experimentation during the preliminary stages of evaluation. In this respect, the manual should This volume contains the proceedings of a meeting provide important background information to held by the Scientific Committee on the Toxicology workers involved with animal systems. The of Metals, a Subcommittee of the Permanent manual has extensive reading lists, and appendices Commission and International Association on relating to media composition and measurements Occupational Health (PCIAOH). The meeting was of cell growth. The list of commercial suppliers is heldatRochester,NewYork,onMay24-27,1982. particularly useful. The volume is typical of all The coverage is extremely comprehensive, Springer-Verlag publications, with excellent including all aspects of the toxicity of metals to layout, and clear line diagrams of plant material reproduction and development, an area all too often and the equipment required for each experiment. It ignored by scientists and toxicologists. It includes should be included in the library of all those the potential effects of metals on the male and workers interested in the culture of plant and female reproductive systems, birth defects and animal tissues. perinatal toxicity, the developing central nervous system and parenteral and postnatal aspects of the M.R.Davey metabolism of metals. As well as providing a wealth of information on the possible effects of metals on reproduction and development in animals and in BIOMEDICAL RESEARCH man, the presentations also cover a bewildering INVOLVING ANIMALS variety ofthe assay techniques and systems used in Edited by Z. Bankowski & N. Howard-Jones this field. These include in vitro methods, clinical humans CIOMS, Geneva, 1984 studies, post-mortem examination of vi + 217 pp. Sw. fro 25.00 killed by accidental exposure, morphological and ISBN 92-9036-017-8 biochemical investigations in animals, and non­ human primate behavioural studies. The first third of the book is taken up with review This book contains the proceedings of the XVUth articles, followed by written papers from more than CIOMS Round Table Conference, held at Geneva, sixty authors. It is well produced, topical, and Switzerland, on 8--9 December 1983, to discuss the contains simple and informative line drawings, Proposed International Guiding Principles on numerous graphs and tables, and clear Biomedical Research Involving Animals. photomicrographs. The Conference itself was reviewed at length in The need to increase our knowledge of the toxic ATLA 11, 163-167, and the Guiding ~nciples effects of metals, such as lead, cadmium and have since been revised in the light of the discussion methylmercury is becoming more imperative, as which took place. The revised Principles are being industrial pollution and delay of parenthood in the submitted to the ClOMS and the WHO for developed world result in greater opportunities for damage occurring to fetal, embryonic or approval, before being widely circulated. This is a very good book, which contains a great reproductive tissues. deal of useful information. The discussions, which will prove excellent. As a reference text, this book are printed verbatim, are particularly revealing. However, the discussion sessions from the meeting ClOMS publications are obtainable either fro~ have not been included, which is unfortunate as the WHO in Geneva or from WHO sales agents In they would undoubtedly have made interesting and thought-provoking reading. many countries. Michael Balls Rosemary Riddell http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alternatives to Laboratory Animals SAGE

Book Review: Biomedical Research Involving Animals

Balls, Michael
Alternatives to Laboratory Animals , Volume 12 (2): 1 – Dec 1, 1984
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Publisher
SAGE
Copyright
© 1984 Fund for the Replacement of Animals in Medical Experiments
ISSN
0261-1929
eISSN
2632-3559
DOI
10.1177/026119298401200211
Publisher site
See Article on Publisher Site

Abstract

BOOK REVIEWS propagation impinge upon the commercial REPRODUCTIVE AND application of this subject. The use of DEVELOPMENTAL TOXICITY OF undifferentiated tissues to assess the physiological METALS activity of exogenously supplied growth regulators Edited by Thomas W. Clarkson, Gunnar F. is also considered. This approach, using plant Nordberg & Polly R. Sager cultures, could be extended to assessments of the Plenum Press, NY,1983 general toxicity of drugs, pesticides, and other xviii + 845 pp. $115.00 chemicals. Extrapolation of such results to animal ISBN 0-306-41396-5 cells could reduce the necessity for live animal experimentation during the preliminary stages of evaluation. In this respect, the manual should This volume contains the proceedings of a meeting provide important background information to held by the Scientific Committee on the Toxicology workers involved with animal systems. The of Metals, a Subcommittee of the Permanent manual has extensive reading lists, and appendices Commission and International Association on relating to media composition and measurements Occupational Health (PCIAOH). The meeting was of cell growth. The list of commercial suppliers is heldatRochester,NewYork,onMay24-27,1982. particularly useful. The volume is typical of all The coverage is extremely comprehensive, Springer-Verlag publications, with excellent including all aspects of the toxicity of metals to layout, and clear line diagrams of plant material reproduction and development, an area all too often and the equipment required for each experiment. It ignored by scientists and toxicologists. It includes should be included in the library of all those the potential effects of metals on the male and workers interested in the culture of plant and female reproductive systems, birth defects and animal tissues. perinatal toxicity, the developing central nervous system and parenteral and postnatal aspects of the M.R.Davey metabolism of metals. As well as providing a wealth of information on the possible effects of metals on reproduction and development in animals and in BIOMEDICAL RESEARCH man, the presentations also cover a bewildering INVOLVING ANIMALS variety ofthe assay techniques and systems used in Edited by Z. Bankowski & N. Howard-Jones this field. These include in vitro methods, clinical humans CIOMS, Geneva, 1984 studies, post-mortem examination of vi + 217 pp. Sw. fro 25.00 killed by accidental exposure, morphological and ISBN 92-9036-017-8 biochemical investigations in animals, and non­ human primate behavioural studies. The first third of the book is taken up with review This book contains the proceedings of the XVUth articles, followed by written papers from more than CIOMS Round Table Conference, held at Geneva, sixty authors. It is well produced, topical, and Switzerland, on 8--9 December 1983, to discuss the contains simple and informative line drawings, Proposed International Guiding Principles on numerous graphs and tables, and clear Biomedical Research Involving Animals. photomicrographs. The Conference itself was reviewed at length in The need to increase our knowledge of the toxic ATLA 11, 163-167, and the Guiding ~nciples effects of metals, such as lead, cadmium and have since been revised in the light of the discussion methylmercury is becoming more imperative, as which took place. The revised Principles are being industrial pollution and delay of parenthood in the submitted to the ClOMS and the WHO for developed world result in greater opportunities for damage occurring to fetal, embryonic or approval, before being widely circulated. This is a very good book, which contains a great reproductive tissues. deal of useful information. The discussions, which will prove excellent. As a reference text, this book are printed verbatim, are particularly revealing. However, the discussion sessions from the meeting ClOMS publications are obtainable either fro~ have not been included, which is unfortunate as the WHO in Geneva or from WHO sales agents In they would undoubtedly have made interesting and thought-provoking reading. many countries. Michael Balls Rosemary Riddell

Journal

Alternatives to Laboratory Animals – SAGE

Published: Dec 1, 1984

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