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G. Warner, Y. Adeleye, T. Ideker, C. Workman, D. Scott (2007)
Development of a systems approach for the analysis of toxicogenomic dataToxicology, 231
Christopher Griffiths, R. Dearman, M. Cumberbatch, Ian Kimber (2005)
Cytokines and Langerhans cell mobilisation in mouse and man.Cytokine, 32 2
I. Gerner, M. Barratt, Stephan Zinke, Kerstin Schlegel, E. Schlede (2004)
Development and Prevalidation of a List of Structure–Activity Relationship Rules to be Used in Expert Systems for Prediction of the Skin-sensitising Properties of ChemicalsAlternatives to Laboratory Animals, 32
M. Divkovic, C. Pease, G. Gerberick, D. Basketter (2005)
Hapten–protein binding: from theory to practical application in the in vitro prediction of skin sensitizationContact Dermatitis, 53
Monika Upadhye, H. Maibach (1992)
Influence of area of application of allergen on sensitization in contact dermatitisContact Dermatitis, 27
I. Kimber, Johanna Pichowski, C. Betts, M. Cumberbatch, D. Basketter, R. Dearman (2001)
Alternative approaches to the identification and characterization of chemical allergens.Toxicology in vitro : an international journal published in association with BIBRA, 15 4-5
François Python, C. Goebel, P. Aeby (2007)
Assessment of the U937 cell line for the detection of contact allergens.Toxicology and applied pharmacology, 220 2
L. Loretz, A. Api, L. Barraj, J. Burdick, D. Davis, W. Dressler, Enrico Gilberti, G. Jarrett, S. Mann, Y. Pan, T. Re, K. Renskers, C. Scrafford, Sally Vater (2006)
Exposure data for personal care products: hairspray, spray perfume, liquid foundation, shampoo, body wash, and solid antiperspirant.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 44 12
H. Barton, W. Chiu, R. Setzer, M. Andersen, A. Bailer, F. Bois, R. Dewoskin, S. Hays, G. Johanson, Nancy Jones, G. Loizou, R. Macphail, C. Portier, M. Spendiff, Y. Tan (2007)
Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation.Toxicological sciences : an official journal of the Society of Toxicology, 99 2
S. Casati, P. Aeby, D. Basketter, A. Cavani, A. Gennari, G. Gerberick, P. Griem, T. Hartung, I. Kimber, J. Lepoittevin, B. Meade, M. Pallardy, N. Rougier, F. Rousset, G. Rubinstenn, F. Sallusto, G. Verheyen, V. Zuang (2005)
Dendritic Cells as a Tool for the Predictive Identification of Skin Sensitisation HazardAlternatives to Laboratory Animals, 33
R. Combes, M. Barratt, M. Balls (2003)
An Overall Strategy for the Testing of Chemicals for Human Hazard and Risk Assessment under the EU REACH SystemAlternatives to Laboratory Animals, 31
C. Benezra (1987)
Molecular aspects of allergic contact dermatitis.Acta dermato-venereologica. Supplementum, 134
David Roberts, A. Aptula, M. Cronin, E. Hulzebos, Grace Patlewicz (2007)
Global (Q)SARs for skin sensitisation–assessment against OECD principlesSAR and QSAR in Environmental Research, 18
G. Gerberick, J. Vassallo, L. Foertsch, B. Price, J. Chaney, J. Lepoittevin (2007)
Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach.Toxicological sciences : an official journal of the Society of Toxicology, 97 2
A. Natsch, H. Gfeller, M. Rothaupt, G. Ellis (2007)
Utility and limitations of a peptide reactivity assay to predict fragrance allergens in vitro.Toxicology in vitro : an international journal published in association with BIBRA, 21 7
G. Guironnet, C. Dalbiez‐Gauthier, F. Rousset, D. Schmitt, J. Péguet-Navarro (2000)
In vitro human T cell sensitization to haptens by monocyte-derived dendritic cells.Toxicology in vitro : an international journal published in association with BIBRA, 14 6
D. Basketter, C. Clapp, D. Jefferies, B. Safford, C. Ryan, F. Gerberick, R. Dearman, I. Kimber (2005)
Predictive identification of human skin sensitization thresholdsContact Dermatitis, 53
K. Soderberg, G. Payne, A. Sato, R. Medzhitov, S. Segal, A. Iwasaki (2005)
Innate control of adaptive immunity via remodeling of lymph node feed arteriole.Proceedings of the National Academy of Sciences of the United States of America, 102 45
J. Cotovio, M. Grandidier, P. Portes, R. Roguet, G. Rubinstenn (2005)
The In Vitro Acute Skin Irritation of Chemicals: Optimisation of the EPISKIN Prediction Model within the Framework of the ECVAM Validation ProcessAlternatives to Laboratory Animals, 33
D. Basketter, D. Jefferies, B. Safford, N. Gilmour, I. Jowsey, J. Mcfadden, Wannisa Chansinghakul, I. Duangdeeden, P. Kullavanijaya (2006)
The impact of exposure variables on the induction of skin sensitizationContact Dermatitis, 55
J. Fentem, P. Carmichael, G. Maxwell, C. Pease, F. Reynolds, G. Warner, C. Westmoreland (2006)
Exploring new approaches to assess safety without animal testing
J. Fentem, M. Chamberlain, Bart Sangster (2004)
The Feasibility of Replacing Animal Testing for Assessing Consumer Safety: A Suggested Future DirectionAlternatives to Laboratory Animals, 32
H. Sakaguchi, T. Ashikaga, Masaaki Miyazawa, Y. Yoshida, Yuichi Ito, K. Yoneyama, Morihiko Hirota, Hiroshi Itagaki, H. Toyoda, Hiroyuki Suzuki (2006)
Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT). II. An inter-laboratory study of the h-CLAT.Toxicology in vitro : an international journal published in association with BIBRA, 20 5
T. Schultz, Jason Yarbrough, E. Johnson (2005)
Structure–activity relationships for reactivity of carbonyl-containing compounds with glutathioneSAR and QSAR in Environmental Research, 16
(2005)
and Langerhans cell mobilisation in mouse and man
L. Loretz, A. Api, L. Babcock, L. Barraj, J. Burdick, K. Cater, G. Jarrett, S. Mann, Y.H.L. Pan, T. Re, K. Renskers, C. Scrafford (2008)
Exposure data for cosmetic products: facial cleanser, hair conditioner, and eye shadow.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 46 5
(2007)
Risk Ass ess ment & New Technologies: Opportunities to Assure Safety Without Animal Testing and Better Protect Pub lic Health
Karsten Ruwiedel, C. Pease, R. Edwards, P. Carmichael, J. Abel, P. Aeby, C. Goebel, E. Fritsche (2007)
Drug metabolism and genotoxicity in different skin model systemsToxicology Letters, 172
Sue Gibbs, J. Sandt, H. Merk, D. Lockley, R. Pendlington, C. Pease (2007)
Xenobiotic metabolism in human skin and 3D human skin reconstructs: a review.Current drug metabolism, 8 8
D. Basketter, C. Pease, G. Kasting, I. Kimber, S. Casati, M. Cronin, W. Diembeck, F. Gerberick, J. Hadgraft, T. Hartung, J. Marty, E. Nikolaidis, G. Patlewicz, D. Roberts, E. Roggen, C. Rovida, J. Sandt (2007)
Skin Sensitisation and Epidermal Disposition: The Relevance of Epidermal Disposition for Sensitisation Hazard Identification and Risk AssessmentAlternatives to Laboratory Animals, 35
H. Kanďárová, M. Liebsch, I. Gerner, E. Schmidt, E. Genschow, D. Traue, H. Spielmann (2005)
The EpiDerm Test Protocol for the Upcoming ECVAM Validation Study on In Vitro Skin Irritation Tests — An Assessment of the Performance of the Optimised TestAlternatives to Laboratory Animals, 33
K. Landsteiner, J. Jacobs (1935)
STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDSThe Journal of Experimental Medicine, 61
Contrad Hauser, S. Katz (1990)
Generation and Characterization of T‐helper Cells by Primary in vitro Sensitization using Langerhans CellsImmunological Reviews, 117
I. Kimber, M. Cumberbatch, C. Betts, R. Dearman (2004)
Dendritic cells and skin sensitisation hazard assessment.Toxicology in vitro : an international journal published in association with BIBRA, 18 2
(2001)
Allergic Con tact Dermatitis, 16pp
Paul Shannon, Andrew Markiel, Owen Ozier, N. Baliga, Jonathan Wang, Daniel Ramage, Nada Amin, Benno Schwikowski, T. Ideker (2003)
Cytoscape: a software environment for integrated models of biomolecular interaction networks.Genome research, 13 11
S. Felter, C. Ryan, D. Basketter, N. Gilmour, G. Gerberick (2003)
Application of the risk assessment paradigm to the induction of allergic contact dermatitis.Regulatory toxicology and pharmacology : RTP, 37 1
H. Kato, M. Okamoto, Kazuko Yamashita, Yosuke Nakamura, Y. Fukumori, Kiyoshi Nakai, H. Kaneko (2003)
Peptide-binding assessment using mass spectrometry as a new screening method for skin sensitization.The Journal of toxicological sciences, 28 1
G. Maxwell, C. Mackay (2008)
Application of a Systems Biology Approach to Skin Allergy Risk AssessmentAlternatives to Laboratory Animals, 36
Rovida Maria, Casati Silvia, Basketter David, Pease Camilla, K. Ian, C. Mark, Diembeck Walter, T. Grace, Roberts Dw, G. Frank, Hadgraft Jonathan, Kasting Gerald, Hartung Thomas, M. Jean, N. Efstathios, R. Erwin, Van Jjm (2007)
Skin Sensitisation and Epidermal Disposition: The Relevance of Epidermal Disposition for Sensitisation Hazard Identification and Risk Assessment
B. Hall, S. Tozer, B. Safford, M. Coroama, W. Steiling, M. Leneveu-Duchemin, C. McNamara, M. Gibney (2007)
European consumer exposure to cosmetic products, a framework for conducting population exposure assessments.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 45 11
C. Ryan, G. Gerberick, L. Gildea, B. Hulette, C. Betts, M. Cumberbatch, R. Dearman, I. Kimber (2005)
Interactions of contact allergens with dendritic cells: opportunities and challenges for the development of novel approaches to hazard assessment.Toxicological sciences : an official journal of the Society of Toxicology, 88 1
P. Aeby, T. Ashikaga, W. Diembeck, D. Eschrich, F. Gerberick, I. Kimber, M. Marrec-Fairley, H. Sakaguchi, M. Tailhardat, S. Teissier, G. Maxwell (2008)
The COLIPA strategy for the development of in vitro alternatives: Skin sensitisation
S. Felter, M. Robinson, D. Basketter, G. Gerberick (2002)
A review of the scientific basis for uncertainty factors for use in quantitative risk assessment for the induction of allergic contact dermatitisContact Dermatitis, 47
D. Basketter, P. Evans, R. Fielder, G. Gerberick, R. Dearman, I. Kimber (2002)
Local lymph node assay - validation, conduct and use in practice.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 40 5
I. Kimber, M. Cumberbatch, Craig Portsmouth, Kirsty Clelland, C. Schramm, G. Maxwell, C. Westmoreland, D. Basketter, R. Dearman (2006)
Synergistic effect of chemical insult and toll-like receptor ligands on dendritic cell activationToxicology Letters, 164
Nathalie Rougier, Gerard Redziniak, Danielle Mougin, D. Schmitt, Claude Vincent (2000)
In vitro evaluation of the sensitization potential of weak contact allergens using langerhans-like dendritic cells and autologous T cells.Toxicology, 145 1
T. Ashikaga, Y. Yoshida, Morihiko Hirota, K. Yoneyama, Hiroshi Itagaki, H. Sakaguchi, Masaaki Miyazawa, Y. Ito, Hiroyuki Suzuki, H. Toyoda (2006)
Development of an in vitro skin sensitization test using human cell lines: the human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol.Toxicology in vitro : an international journal published in association with BIBRA, 20 5
C. Giese, C. Demmler, R. Ammer, S. Hartmann, A. Lubitz, Lilja Miller, Riccarda Müller, U. Marx (2006)
A human lymph node in vitro--challenges and progress.Artificial organs, 30 10
I. Jowsey (2007)
Proactive surveillance of contact allergies: an important component of the risk management strategy for skin sensitizersContact Dermatitis, 56
J. Lepoittevin (2006)
Metabolism versus chemical transformation or pro‐ versus prehaptens?Contact Dermatitis, 54
U. Sauer, Matthias Heinemann, Nicola Zamboni (2007)
Getting Closer to the Whole PictureScience, 316
G. Gerberick, C. Ryan, P. Kern, R. Dearman, I. Kimber, G. Patlewicz, D. Basketter (2004)
A chemical dataset for evaluation of alternative approaches to skin‐sensitization testingContact Dermatitis, 50
I. Kimber, D. Basketter, M. Butler, A. Gamer, J. Garrigue, G. Gerberick, C. Newsome, W. Steiling, H. Vohr (2003)
Classification of contact allergens according to potency: proposals.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 41 12
D. Basketter, D. Kan-King-Yu, P. Dierkes, I. Jowsey (2007)
Does Irritation Potency Contribute to the Skin Sensitization Potency of Contact Allergens?Cutaneous and Ocular Toxicology, 26
A. Schnuch, J. Geier, W. Uter, D. Basketter, I. Jowsey (2007)
The biocide polyhexamethylene biguanide remains an uncommon contact allergenContact Dermatitis, 56
N. Aptula, D. Roberts, T. Schultz, C. Pease (2007)
Reactivity assays for non-animal based prediction of skin sensitisation potentialToxicology, 231
H. Sakaguchi, M. Miyazawa, Y. Yoshida, Yuichi Ito, Hiroyuki Suzuki (2007)
Prediction of preservative sensitization potential using surface marker CD86 and/or CD54 expression on human cell line, THP-1Archives of Dermatological Research, 298
L. Loretz, A. Api, L. Barraj, J. Burdick, W. Dressler, S. Gettings, H. Hsu, Y.H.L. Pan, T. Re, K. Renskers, A. Rothenstein, C. Scrafford, C. Sewall (2005)
Exposure data for cosmetic products: lipstick, body lotion, and face cream.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 43 2
I. Jowsey, D. Basketter, C. Westmoreland, I. Kimber (2006)
A future approach to measuring relative skin sensitising potency: a proposalJournal of Applied Toxicology, 26
D. Roberts, A. Aptula, G. Patlewicz, C. Pease (2008)
Chemical reactivity indices and mechanism‐based read‐across for non‐animal based assessment of skin sensitisation potentialJournal of Applied Toxicology, 28
D. Basketter, R. Rodford, I. Kimber, Ian Smith, J. Wahlberg (1999)
Skin sensitization risk assessment: a comparative evaluation of 3 isothiazolinone biocidesContact Dermatitis, 40
R. Pendlington, H. Minter, L. Stupart, C. Mackay, C. Roper, D. Sanders, C. Pease (2007)
Further development of an in vitro skin absorption method to measure compartmental disposition and kinetics for chemicals in skinToxicology Letters, 172
Moa Bergström, H. Ott, Anna-Carin Carlsson, M. Neis, G. Zwadlo‐Klarwasser, C. Jonsson, H. Merk, A. Karlberg, J. Baron (2007)
A skin-like cytochrome P450 cocktail activates prohaptens to contact allergenic metabolites.The Journal of investigative dermatology, 127 5
A. Martín-Fontecha, S. Sebastiani, U. Höpken, M. Uguccioni, M. Lipp, A. Lanzavecchia, F. Sallusto (2003)
Regulation of Dendritic Cell Migration to the Draining Lymph NodeThe Journal of Experimental Medicine, 198
Allergic Contact Dermatitis (ACD; chemical-induced skin sensitisation) represents a key consumer safety endpoint for the cosmetics industry. At present, animal tests (predominantly the mouse Local Lymph Node Assay) are used to generate skin sensitisation hazard data for use in consumer safety risk assessments. An animal testing ban on chemicals to be used in cosmetics will come into effect in the European Union (EU) from March 2009. This animal testing ban is also linked to an EU marketing ban on products containing any ingredients that have been subsequently tested in animals, from March 2009 or March 2013, depending on the toxicological endpoint of concern. Consequently, the testing of cosmetic ingredients in animals for their potential to induce skin sensitisation will be subject to an EU marketing ban, from March 2013 onwards. Our conceptual framework and strategy to deliver a non-animal approach to consumer safety risk assessment can be summarised as an evaluation of new technologies (e.g. ‘omics’, informatics), leading to the development of new non-animal (in silico and in vitro) predictive models for the generation and interpretation of new forms of hazard characterisation data, followed by the development of new risk assessment approaches to integrate these new forms of data and information in the context of human exposure. Following the principles of the conceptual framework, we have been investigating existing and developing new technologies, models and approaches, in order to explore the feasibility of delivering consumer safety risk assessment decisions in the absence of new animal data. We present here our progress in implementing this conceptual framework, with the skin sensitisation endpoint used as a case study.
Alternatives to Laboratory Animals – SAGE
Published: Nov 1, 2008
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