Access the full text.
Sign up today, get DeepDyve free for 14 days.
O. Lowry, N. Rosebrough, A. Farr, R. Randall (1951)
Protein measurement with the Folin phenol reagent.The Journal of biological chemistry, 193 1
(2004)
Effects of two different fungal spore types often found in moisture-damaged buildings on cytokine production and apoptosis in alveolar rat macrophages
L. Bingle, T. Bull, B. Fox, A. Guz, R. Richards, T. Tetley (1990)
Type II pneumocytes in mixed cell culture of human lung: a light and electron microscopic study.Environmental Health Perspectives, 85
M. Anderson (1985)
Determination of glutathione and glutathione disulfide in biological samples.Methods in enzymology, 113
Q. Myrvik, E. Leake, B. Fariss (1961)
Studies on pulmonary alveolar macrophages from the normal rabbit: a technique to procure them in a high state of purity.Journal of immunology, 86
(2004)
Indoor Stachybotrys chartarum and its toxicity
K. Huttunen, A. Hyvärinen, A. Nevalainen, H. Komulainen, M. Hirvonen (2003)
Production of proinflammatory mediators by indoor air bacteria and fungal spores in mouse and human cell lines.Environmental Health Perspectives, 111
S. Hinkley, E. Mazzola, J. Fettinger, Y. Lam, B. Jarvis (2000)
Atranones A-G, from the toxigenic mold Stachybotrys chartarum.Phytochemistry, 55 6
P. Hoet, C. Lewis, M. Demedts, B. Nemery (1994)
Putrescine and paraquat uptake in human lung slices and isolated type II pneumocytes.Biochemical pharmacology, 48 3
Roy Richards, N. Davies, J. Atkins, V. Oreffo (2007)
Isolation, biochemical characterization, and culture of lung type II cells of the ratLung, 165
V. Castranova, J. Rabovsky, J. Tucker, P. Miles, P. Miles (1988)
The alveolar type II epithelial cell: a multifunctional pneumocyte.Toxicology and applied pharmacology, 93 3
M. Kasper, D. Schuh, M. Müller (1994)
Bauhinia purpurea lectin (BPA) binding of rat type I pneumocytes: alveolar epithelial alterations after radiation-induced lung injury.Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 46 4-5
(2002)
Characterisation of morphologically, chemically and physiologically different Stachybotrys species from water-damaged buildings
J. Edelson, J. Shannon, R. Mason (1988)
Alkaline phosphatase: a marker of alveolar type II cell differentiation.The American review of respiratory disease, 138 5
S. Sorokin (1970)
Properties of alveolar cells and tissues that strengthen alveolar defenses.Archives of internal medicine, 126 3
M. Andersson, M. Nikulin, U. Kõljalg, M. Andersson, Frederic Rainey, Kari Reijula, E. Hintikka, Mirja Salkinoja-Salonen (1997)
Bacteria, molds, and toxins in water-damaged building materialsApplied and Environmental Microbiology, 63
K. Nielsen, K. Huttunen, A. Hyvärinen, B. Andersen, B. Jarvis, M. Hirvonen (2004)
Metabolite profiles of Stachybotrys isolates from water-damaged buildings and their induction of inflammatory mediators and cytotoxicity in macrophagesMycopathologia, 154
J. Brain (1992)
Mechanisms, measurement, and significance of lung macrophage function.Environmental Health Perspectives, 97
H. Koshinsky, G. Khachatourians (1992)
Trichothecene synergism, additivity, and antagonism: the significance of the maximally quiescent ratio.Natural toxins, 1 1
S. Hinkley, B. Jarvis (2001)
15 Chromatographic Method for Stachybotrys ToxinsMethods of Molecular Biology, 157
S. McBride, E. Tátrai, R. Blundell, Z. Kováčiková, L. Cardozo, Z. Adamis, Tim Smith, D. Harrison (2004)
Characterisation of Lectin Binding Patterns of Mouse Bronchiolar and Rat Alveolar Epithelial Cells in CultureThe Histochemical Journal, 32
C. Mason, T. Rand, M. Oulton, J. MacDonald, J. Scott (1998)
Effects of Stachybotrys chartarum (atra) conidia and isolated toxin on lung surfactant production and homeostasis.Natural toxins, 6 1
(2003)
Toxic effects of Stachybotrys chartarum
D. Paglia, W. Valentine (1967)
Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase.The Journal of laboratory and clinical medicine, 70 1
S. Hinkley, B. Jarvis (2001)
Chromatographic method for Stachybotrys toxins.Methods in molecular biology, 157
E. Piecková, Z. Jesenská (1999)
Microscopic fungi in dwellings and their health implications in humans.Annals of agricultural and environmental medicine : AAEM, 6 1
During a study of indoor fungal colonisation, several isolates of Stachybotrys chartarum were recovered, and the effects of metabolites from four isolates on lung epithelial Type II cells and alveolar macrophages were studied in vitro. All the isolates showed toxic effects on both cell types, and they differed only in the extent of the changes induced. In Type II cells, the number of alkaline phosphatase positive cells was reduced, the pattern of Maclura pomifera agglutinin (MPA) binding was changed, and acid phosphatase activity in alveolar macrophages was diminished. In both cell types, the production of monocyte chemotactic protein-1 (MCP-1) and tumour necrosis factor-alpha (TNF-alpha) was changed, and parameters related to antioxidant status (superoxide dismutase, glutathione peroxidase, glutathione) were decreased.
Alternatives to Laboratory Animals – SAGE
Published: Mar 1, 2007
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.