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Huimin Zhu, Zhiqiang Wang, Jixu Yu, Xiuli Yang, F. He, Zhenchuan Liu, F. Che, Xuemei Chen, Honglei Ren, Michael Hong, Jian Wang (2019)
Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhageProgress in Neurobiology, 178
F. Bartoli, C. Brita, C. Crocamo, M. Clerici, G. Carrà (2018)
Early Post-stroke Depression and Mortality: Meta-Analysis and Meta-RegressionFrontiers in Psychiatry, 9
H. Miao, R. Li, Cong Han, Xiu-Zhi Lu, Hang Zhang (2018)
Minocycline promotes posthemorrhagic neurogenesis via M2 microglia polarization via upregulation of the TrkB/BDNF pathway in rats.Journal of neurophysiology, 120 3
Andrea Benedict, A. Mountney, Andrés Hurtado, Kelley Bryan, R. Schnaar, A. Dinkova-Kostova, P. Talalay (2012)
Neuroprotective effects of sulforaphane after contusive spinal cord injury.Journal of neurotrauma, 29 16
Q Li, J Wan, X Lan (2017)
Neuroprotection of brain-permeable iron chelator VK-28 against intracerebral hemorrhage in miceJ Cereb Blood Flow Metab, 37
R. Villa, F. Ferrari, A. Moretti (2017)
Post‐stroke depression: Mechanisms and pharmacological treatmentPharmacology & Therapeutics, 184
R. Duman (2007)
Role of neurotrophic factors in the etiology and treatment of mood disordersNeuroMolecular Medicine, 5
Xiaoyu Shi, Huiying Bai, Junmin Wang, Jiarui Wang, Leo Huang, Meimei He, Xuejun Zheng, Zitian Duan, Danyang Chen, Jiaxin Zhang, Xuemei Chen, Jian Wang (2021)
Behavioral Assessment of Sensory, Motor, Emotion, and Cognition in Rodent Models of Intracerebral HemorrhageFrontiers in Neurology, 12
J. Chen‐Roetling, R. Regan (2017)
Targeting the Nrf2-Heme Oxygenase-1 Axis after Intracerebral Hemorrhage.Current pharmaceutical design, 23 15
Wei Hua, Xuemei Chen, Junmin Wang, Weidong Zang, Chao Jiang, Honglei Ren, Michael Hong, Jiarui Wang, He Wu, Jian Wang (2020)
Mechanisms and potential therapeutic targets for spontaneous intracerebral hemorrhageBrain Hemorrhages
Yuan Yang, Meikui Zhang, Xiaoni Kang, Chen Jiang, Huan Zhang, Pei-qi Wang, Jingjing Li (2015)
Impaired adult hippocampal neurogenesis and cognitive ability in a mouse model of intrastriatal hemorrhageNeuroscience Letters, 599
Josefine Nygren, T. Wieloch (2005)
Enriched Environment Enhances Recovery of Motor Function after Focal Ischemia in Mice, and Downregulates the Transcription Factor NGFI-AJournal of Cerebral Blood Flow & Metabolism, 25
Izumi Maezawa, Lee‐way Jin (2010)
Rett Syndrome Microglia Damage Dendrites and Synapses by the Elevated Release of GlutamateThe Journal of Neuroscience, 30
Marie-Claude Audet, H. Anisman (2013)
Interplay between pro-inflammatory cytokines and growth factors in depressive illnessesFrontiers in Cellular Neuroscience, 7
Andrew Slater, Lei Cao (2015)
A Protocol for Housing Mice in an Enriched EnvironmentJournal of Visualized Experiments : JoVE
J. Li, Yan-dong Zhao, Jun-wei Zeng, Xiao-yan Chen, Ruo-Dan Wang, Sai-yu Cheng (2014)
Serum Brain-derived neurotrophic factor levels in post-stroke depression.Journal of affective disorders, 168
M. Vrinda, A. Sasidharan, S. Aparna, B. Srikumar, B. Kutty, B. Rao (2017)
Enriched environment attenuates behavioral seizures and depression in chronic temporal lobe epilepsyEpilepsia, 58
A. Ohlsson, B. Johansson (1995)
Environment influences functional outcome of cerebral infarction in rats.Stroke, 26 4
L. Zhao, A. Risedal, A. Wojcik, Jan Hejzlar, B. Johansson, Z. Kokaia (2001)
Enriched environment influences brain-derived neurotrophic factor levels in rat forebrain after focal strokeNeuroscience Letters, 305
Sara Stern-Nezer, I. Eyngorn, M. Mlynash, Ryan Snider, Chitra Venkatsubramanian, C. Wijman, M. Buckwalter (2017)
Depression one year after hemorrhagic stroke is associated with late worsening of outcomes.NeuroRehabilitation, 41 1
B. Johansson, A. Ohlsson (1996)
Environment, Social Interaction, and Physical Activity as Determinants of Functional Outcome after Cerebral Infarction in the RatExperimental Neurology, 139
Andiara Freitas, J. Egea, I. Buendía, V. Gómez-Rangel, E. Parada, Elisa Navarro, A. Casas, A. Wojnicz, J. Ortiz, A. Cuadrado, A. Ruiz-Nuño, A. Rodrigues, Manuela López (2015)
Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in MiceMolecular Neurobiology, 53
Jian Wang, J. Fields, Chunying Zhao, J. Langer, R. Thimmulappa, T. Kensler, Masayuki Yamamoto, S. Biswal, S. Doré (2007)
Role of Nrf2 in protection against intracerebral hemorrhage injury in mice.Free radical biology & medicine, 43 3
Dan Zhao, Xulin Xu, Lin-na Pan, Wei Zhu, Xiaopei Fu, Lian-Jun Guo, Q. Lu, Jian Wang (2017)
Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stressJournal of Neuroinflammation, 14
Che-Feng Chang, S. Cho, Jian Wang (2014)
(-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathwaysAnnals of Clinical and Translational Neurology, 1
Josefine Nygren, M. Kokaia, T. Wieloch (2006)
Decreased expression of brain‐derived neurotrophic factor in BDNF+/− mice is associated with enhanced recovery of motor performance and increased neuroblast number following experimental strokeJournal of Neuroscience Research, 84
Peijun Jia, Jinxin He, Zefu Li, Junmin Wang, Lin Jia, Ruochen Hao, Jonathan Lai, Weidong Zang, Xuemei Chen, Jian Wang (2021)
Profiling of Blood-Brain Barrier Disruption in Mouse Intracerebral Hemorrhage Models: Collagenase Injection vs. Autologous Arterial Whole Blood InfusionFrontiers in Cellular Neuroscience, 15
Qian Li, Xiaoning Han, Xi Lan, Yufeng Gao, Jie-ru Wan, Frederick Durham, Tian Cheng, Jie Yang, Zhong-yu Wang, Chao Jiang, M. Ying, R. Koehler, B. Stockwell, Jian Wang (2017)
Inhibition of neuronal ferroptosis protects hemorrhagic brain.JCI insight, 2 7
Xiaolei Zhu, Michael Nedelcovych, A. Thomas, Yuto Hasegawa, Aisa Moreno-Megui, Wade Coomer, V. Vohra, Atsushi Saito, Gabriel Perez, Ying Wu, J. Alt, Eva Prchalová, L. Tenora, P. Majer, R. Rais, C. Rojas, B. Slusher, A. Kamiya (2018)
JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stressNeuropsychopharmacology, 44
Jian Wang, S. Doré (2007)
Inflammation after Intracerebral HemorrhageJournal of Cerebral Blood Flow & Metabolism, 27
Xinxin Zhang, Mei Yuan, Songbin Yang, Xiaoya Chen, Jichun Wu, Mingyue Wen, K. Yan, Xia Bi (2020)
Enriched environment improves post-stroke cognitive impairment and inhibits neuroinflammation and oxidative stress by activating Nrf2-ARE pathwayInternational Journal of Neuroscience, 131
Xi Lan, Xiaoning Han, Qian Li, Jian Wang (2017)
(−)-Epicatechin, a Natural Flavonoid Compound, Protects Astrocytes Against Hemoglobin Toxicity via Nrf2 and AP-1 Signaling PathwaysMolecular Neurobiology, 54
Xiaoning Han, Xi Lan, Qiang Li, Yufeng Gao, Wei Zhu, Tian Cheng, T. Maruyama, Jian Wang (2016)
Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injuryJournal of Cerebral Blood Flow & Metabolism, 36
E. Kobayashi, Takafumi Suzuki, R. Funayama, Takeshi Nagashima, M. Hayashi, Hiroki Sekine, N. Tanaka, Takashi Moriguchi, H. Motohashi, K. Nakayama, Masayuki Yamamoto (2016)
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcriptionNature Communications, 7
S. Kreisel, H. Bäzner, M. Hennerici (2006)
Pathophysiology of Stroke Rehabilitation: Temporal Aspects of Neurofunctional RecoveryCerebrovascular Diseases, 21
Partha Chandra, Sinisa Cikic, M. Baddoo, I. Rutkai, J. Guidry, E. Flemington, P. Katakam, D. Busija (2021)
Transcriptome analysis reveals sexual disparities in gene expression in rat brain microvesselsJournal of Cerebral Blood Flow & Metabolism, 41
G. Kronenberg, K. Gertz, A. Heinz, M. Endres (2014)
Of mice and men: modelling post‐stroke depression experimentallyBritish Journal of Pharmacology, 171
P. Feng, Chunfa Huang (2013)
Phospholipase D-mTOR signaling is compromised in a rat model of depression.Journal of psychiatric research, 47 5
Mei-xue Dong, Chenmeng Li, Peng Shen, Qingchuan Hu, Youdong Wei, Yifei Ren, Jia Yu, Siwen Gui, Yiyun Liu, J. Pan, P. Xie (2018)
Recombinant tissue plasminogen activator induces long-term anxiety-like behaviors via the ERK1/2-GAD1-GABA cascade in the hippocampus of a rat modelNeuropharmacology, 128
B. Ickes, T. Pham, L. Sanders, D. Albeck, A. Mohammed, A. Granholm (2000)
Long-Term Environmental Enrichment Leads to Regional Increases in Neurotrophin Levels in Rat BrainExperimental Neurology, 164
A. Mansour, Run Xiao, Stephen Bergin, Wei Huang, Logan Chrislip, Jianying Zhang, Seemaab Ali, N. Queen, M. Caligiuri, Lei Cao (2020)
Enriched environment enhances NK cell maturation through hypothalamic BDNF in male miceEuropean Journal of Immunology, 51
Ruoyu Zhang, Junmin Wang, Leo Huang, Tom Wang, Yinrou Huang, Zefu Li, Jinxin He, Chen Sun, J. Wang, Xuemei Chen, Jian Wang (2021)
The pros and cons of motor, memory, and emotion-related behavioral tests in the mouse traumatic brain injury modelNeurological Research, 44
Zhen Zhang, Yuejia Song, Ze Zhang, Danyang Li, Hong Zhu, Rui Liang, Yun-he Gu, Yuxin Pang, Jiping Qi, He Wu, Jian Wang (2017)
Distinct role of heme oxygenase-1 in early- and late-stage intracerebral hemorrhage in 12-month-old miceJournal of Cerebral Blood Flow & Metabolism, 37
Guofeng Wu, Shen Li, Likun Wang, Yuan-hong Mao (2013)
The perihematomal glutamate level is associated with the outcome of patients with basal ganglia hematomas treated by inimally invasive proceduresNeurological Research, 35
Syed Ahmed, Lin Luo, Akhileshwar Namani, X. Wang, Xiuwen Tang (2017)
Nrf2 signaling pathway: Pivotal roles in inflammation.Biochimica et biophysica acta. Molecular basis of disease, 1863 2
Xiaochun Zhao, Tao Wu, Che-Feng Chang, He Wu, Xiaoning Han, Qian Li, Yufeng Gao, Qiang Li, Zhipeng Hou, T. Maruyama, Jiangyang Zhang, Jian Wang (2015)
Toxic role of prostaglandin E2 receptor EP1 after intracerebral hemorrhage in miceBrain, Behavior, and Immunity, 46
Wei Zhu, Yufeng Gao, Jie-ru Wan, Xi Lan, Xiaoning Han, Shan-shan Zhu, Weidong Zang, Xuemei Chen, W. Ziai, D. Hanley, S. Russo, R. Jorge, Jian Wang (2018)
Changes in motor function, cognition, and emotion-related behavior after right hemispheric intracerebral hemorrhage in various brain regions of mouseBrain, Behavior, and Immunity, 69
Honglei Ren, Ranran Han, Xuemei Chen, Xi Liu, Jie-ru Wan, Limin Wang, Xiuli Yang, Jian Wang (2020)
Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: An updateJournal of Cerebral Blood Flow & Metabolism, 40
Wei Zhu, Yufeng Gao, Che-Feng Chang, Jie-ru Wan, Shan-shan Zhu, Jian Wang (2014)
Mouse Models of Intracerebral Hemorrhage in Ventricle, Cortex, and Hippocampus by Injections of Autologous Blood or CollagenasePLoS ONE, 9
A. Can, David Dao, C. Terrillion, S. Piantadosi, Shambhu Bhat, T. Gould (2011)
The tail suspension test.Journal of visualized experiments : JoVE, 59
Luana Manosso, M. Moretti, Julia Rosa, M. Cunha, A. Rodrigues (2017)
Evidence for the involvement of heme oxygenase-1 in the antidepressant-like effect of zincPharmacological Reports, 69
G. Carlson, R. Lin, Y. Chen, B. Brookshire, R. White, I. Lucki, S. Siegel, S. Kim (2016)
Dexras1 a unique ras-GTPase interacts with NMDA receptor activity and provides a novel dissociation between anxiety, working memory and sensory gatingNeuroscience, 322
Feixue Wang, P. Wan, Weiyao Wang, Bin Xiao, Hua Jin, Q. Jin (2019)
Dopamine in the hippocampal dentate gyrus modulates spatial learning via D1-like receptorsBrain Research Bulletin, 144
Tao Wu, He Wu, Jessica Wang, Jian Wang (2011)
Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brainJournal of Neuroinflammation, 8
José Castillo, Antonio Dávalos, J. Álvarez-Sabín, J. Pumar, R. Leira, Y. Silva, Joan Montaner, Carlos Kase (2002)
Molecular signatures of brain injury after intracerebral hemorrhageNeurology, 58
(2021)
Impact of sex and APOE e4 on age-related cerebral perfusion trajectories in cognitively asymptomatic Middle-aged and older adults: a longitudinal study
Yujing Zhang, Dan Xu, Hong Qi, Yin Yuan, Hong Liu, S. Yao, Shi-ying Yuan, Jiancheng Zhang (2018)
Enriched environment promotes post-stroke neurogenesis through NF-κB-mediated secretion of IL-17A from astrocytesBrain Research, 1687
T. Strekalova, M. Evans, J. Costa-Nunes, S. Bachurin, N. Yeritsyan, Y. Couch, H. Steinbusch, S. Köhler, K. Lesch, D. Anthony (2015)
Tlr4 upregulation in the brain accompanies depression- and anxiety-like behaviors induced by a high-cholesterol dietBrain, Behavior, and Immunity, 48
He Wu, Tao Wu, Xiaoning Han, Jie-ru Wan, Chao Jiang, Wenwu Chen, Hong Lu, Qingwu Yang, Jian Wang (2017)
Cerebroprotection by the neuronal PGE2 receptor EP2 after intracerebral hemorrhage in middle-aged miceJournal of Cerebral Blood Flow & Metabolism, 37
I. Mendez-David, L. Tritschler, Z. Ali, Marie-Hélène Damiens, M. Pallardy, D. David, S. Kerdine-Römer, A. Gardier (2015)
Nrf2-signaling and BDNF: A new target for the antidepressant-like activity of chronic fluoxetine treatment in a mouse model of anxiety/depressionNeuroscience Letters, 597
Yang Yang, Kaiyuan Zhang, Jun Zhong, Ju Wang, Zhongyuan Yu, Xuejiao Lei, Xuezhu Chen, Yulian Quan, Jishu Xian, Yujie Chen, Xin Liu, H. Feng, Liang Tan (2018)
Stably maintained microtubules protect dopamine neurons and alleviate depression-like behavior after intracerebral hemorrhageScientific Reports, 8
A. Jayakumar, K. Rao, Ch.R.K. Murthy, M. Norenberg (2006)
Glutamine in the mechanism of ammonia-induced astrocyte swellingNeurochemistry International, 48
A. Thomas, C. O'driscoll, J. Bressler, W. Kaufmann, C. Rojas, B. Slusher (2014)
Small molecule glutaminase inhibitors block glutamate release from stimulated microglia.Biochemical and biophysical research communications, 443 1
J. Sánchez-Román, J. Varela-Aguilar, J. Bravo-Ferrer, E. Madueño, M. Bobadilla (1993)
Idiopathic orbital myositis: treatment with cyclosporin.Annals of the Rheumatic Diseases, 52
Dan Fan, Jun Li, Bin Zheng, Lei Hua, Zhiyi Zuo (2014)
Enriched Environment Attenuates Surgery-Induced Impairment of Learning, Memory, and Neurogenesis Possibly by Preserving BDNF ExpressionMolecular Neurobiology, 53
Chao Feng, M. Fang, Xueyuan Liu (2014)
The Neurobiological Pathogenesis of Poststroke DepressionThe Scientific World Journal, 2014
D. McCarthy, R. Alexander, Mark Smith, S. Pathak, S. Kanes, Chi-Ming Lee, G. Sanacora (2012)
Glutamate-based depression GBD.Medical hypotheses, 78 5
Michael Maes, Z. Fišar, M. Medina, G. Scapagnini, G. Nowak, M. Berk (2012)
New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitorsInflammopharmacology, 20
Jie-ru Wan, Honglei Ren, Jian Wang (2019)
Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhageStroke and Vascular Neurology, 4
Zhen Zhang, Ze Zhang, Hong Lu, Qingwu Yang, He Wu, Jian Wang (2016)
Microglial Polarization and Inflammatory Mediators After Intracerebral HemorrhageMolecular Neurobiology, 54
R. Nudo, Birute Wise, Frank SiFuentes, G. Milliken (1996)
Neural Substrates for the Effects of Rehabilitative Training on Motor Recovery After Ischemic InfarctScience, 272
Chen Danyang, Junmin Wang, Yinpei Xing, Peijun Jia, Yuheng Zhang, Jiarui Wang, Honglei Ren, Anh Le, Xuemei Chen, Jian Wang (2020)
Behavioral assessment of post-stroke depression and anxiety in rodentsBrain Hemorrhages
C. Cirillo, N. Brihmat, E. Castel-Lacanal, Alice Friec, M. Barbieux-Guillot, N. Raposo, J. Pariente, A. Viguier, M. Simonetta-Moreau, J. Albucher, J. Olivot, F. Desmoulin, P. Marque, F. Chollet, I. Loubinoux (2020)
Post-stroke remodeling processes in animal models and humansJournal of Cerebral Blood Flow & Metabolism, 40
Q. Li, Jian Wang (2017)
Animal Models: Cerebral HemorrhagePrimer on Cerebrovascular Diseases
Nataliia Bakunina, C. Pariante, P. Zunszain (2015)
Immune mechanisms linked to depression via oxidative stress and neuroprogressionImmunology, 144
Jian Wang, S. Doré (2007)
Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage.Brain : a journal of neurology, 130 Pt 6
P Jia, J He, Z Li (2021)
Profiling of Blood-Brain barrier disruption in mouse intracerebral hemorrhage models: collagenase injection vsFront Cell Neurosci, 15
Qiang Li, Xiaoning Han, Xi Lan, Xiaohua Hong, Qian Li, Yufeng Gao, Tianqi Luo, Qingwu Yang, R. Koehler, Yu Zhai, Jinyuan Zhou, Jian Wang (2017)
Inhibition of tPA-induced hemorrhagic transformation involves adenosine A2b receptor activation after cerebral ischemiaNeurobiology of Disease, 108
Yanting Gu, Yinfeng Dong, Jie-ru Wan, Honglei Ren, R. Koehler, Jian Wang (2022)
Interleukin-10 deficiency aggravates traumatic brain injury in male but not female miceExperimental Neurology, 355
Nao Hirata, S. Hattori, Hirotaka Shoji, H. Funakoshi, T. Miyakawa (2018)
Comprehensive behavioral analysis of indoleamine 2,3‐dioxygenase knockout miceNeuropsychopharmacology Reports, 38
Xiang-Sheng Zhang, Qi Wu, Yue Lu, Jie-ru Wan, Haibin Dai, Xiao-ming Zhou, Sheng-yin Lv, Xuemei Chen, Xin Zhang, C. Hang, Jian Wang (2018)
Cerebroprotection by salvianolic acid B after experimental subarachnoid hemorrhage occurs via Nrf2‐ and SIRT1‐dependent pathwaysFree Radical Biology and Medicine, 124
J. Boltze, J. Aronowski, J. Badaut, M. Buckwalter, Mateo Caleo, M. Chopp, K. Dave, Nadine Didwischus, R. Dijkhuizen, T. Doeppner, J. Dreier, K. Fouad, M. Gelderblom, K. Gertz, Dominika Golubczyk, B. Gregson, E. Hamel, D. Hanley, W. Härtig, F. Hummel, Maulana Ikhsan, M. Janowski, J. Jolkkonen, S. Karuppagounder, R. Keep, I. Koerte, Z. Kokaia, Peiying Li, Fudong Liu, I. Lizasoaín, P. Ludewig, G. Metz, A. Montagne, A. Obenaus, A. Palumbo, M. Pearl, M. Perez-Pinzon, A. Planas, N. Plesnila, A. Raval, M. Rueger, L. Sansing, F. Sohrabji, C. Stagg, R. Stetler, A. Stowe, Dandan Sun, A. Taguchi, M. Tanter, S. Vay, R. Vemuganti, D. Vivien, P. Walczak, Jian Wang, Y. Xiong, M. Zille (2021)
New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular DiseasesFrontiers in Aging Neuroscience, 13
L. Sifonios, M. Trinchero, M. Cereseto, A. Ferrero, M. Cladouchos, G. Macedo, A. Reinés, S. Wikinski (2009)
An enriched environment restores normal behavior while providing cytoskeletal restoration and synaptic changes in the hippocampus of rats exposed to an experimental model of depressionNeuroscience, 164
Jia Wang, S. Doré (2008)
Heme oxygenase 2 deficiency increases brain swelling and inflammation after intracerebral hemorrhageNeuroscience, 155
Otto Witte (1998)
Lesion-induced plasticity as a potential mechanism for recovery and rehabilitative training.Current opinion in neurology, 11 6
Honglei Ren, Ranran Han, Xi Liu, Limin Wang, R. Koehler, Jian Wang (2021)
Nrf2-BDNF-TrkB pathway contributes to cortical hemorrhage-induced depression, but not sex differencesJournal of Cerebral Blood Flow & Metabolism, 41
Linmei Wang, Min Cao, Tinglin Pu, Huang Huang, Charles Marshall, Ming Xiao (2018)
Enriched Physical Environment Attenuates Spatial and Social Memory Impairments of Aged Socially Isolated MiceInternational Journal of Neuropsychopharmacology, 21
Y. Shirayama, A. Chen, S. Nakagawa, D. Russell, R. Duman (2002)
Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of DepressionThe Journal of Neuroscience, 22
P. Dahlqvist, A. Rönnbäck, A. Risedal, R. Nergårdh, I. Johansson, J. Seckl, B. Johansson, T. Olsson (2003)
Effects of postischemic environment on transcription factor and serotonin receptor expression after permanent focal cortical ischemia in ratsNeuroscience, 119
V. Paban, C. Chambon, C. Manrique, C. Touzet, B. Alescio-Lautier (2011)
Neurotrophic signaling molecules associated with cholinergic damage in young and aged rats: Environmental enrichment as potential therapeutic agentNeurobiology of Aging, 32
M. Christensen, S. Mayer, Jean-Marc Ferran, B. Kissela (2009)
Depressed Mood after Intracerebral Hemorrhage: The FAST TrialCerebrovascular Diseases, 27
I. Loubinoux, G. Kronenberg, M. Endres, P. Schumann-Bard, T. Freret, R. Filipkowski, L. Kaczmarek, A. Popa-Wagner (2012)
Post-stroke depression: mechanisms, translation and therapyJournal of Cellular and Molecular Medicine, 16
Junmin Wang, Chao Jiang, Kun Zhang, Xi Lan, Xuemei Chen, Weidong Zang, Zhong-yu Wang, F. Guan, Changlian Zhu, Xiuli Yang, Hong Lu, Jian Wang (2019)
Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathwayFree Radical Biology and Medicine, 131
Post-stroke depression exacerbates neurologic deficits and quality of life. Depression after ischemic stroke is known to some extent. However, depression after intracerebral hemorrhage (ICH) is relatively unknown. Increasing evidence shows that exposure to an enriched environment (EE) after cerebral ischemia/reperfusion injury has neuroprotective effects in animal models, but its impact after ICH is unknown. In this study, we investigated the effect of EE on long-term functional outcomes in mice subjected to collagenase-induced striatal ICH. Mice were subjected to ICH with the standard environment (SE) or ICH with EE for 6 h/day (8:00 am–2:00 pm). Depressive, anxiety-like behaviors and cognitive tests were evaluated on day 28 with the sucrose preference test, tail suspension test, forced swim test, light-dark transition experiment, morris water maze, and novel object recognition test. Exposure to EE improved neurologic function, attenuated depressive and anxiety-like behaviors, and promoted spatial learning and memory. These changes were associated with increased expression of transcription factor Nrf2 and brain-derived neurotrophic factor (BDNF) and inhibited glutaminase activity in the perihematomal tissue. However, EE did not change the above behavioral outcomes in Nrf2−/− mice on day 28. Furthermore, exposure to EE did not increase BDNF expression compared to exposure to SE in Nrf2−/− mice on day 28 after ICH. These findings indicate that EE improves long-term outcomes in sensorimotor, emotional, and cognitive behavior after ICH and that the underlying mechanism involves the Nrf2/BDNF/glutaminase pathway.
Journal of Cerebral Blood Flow & Metabolism – SAGE
Published: May 1, 2023
Keywords: Anxiety behaviors; enriched environment; intracerebral hemorrhage; nuclear regulatory factor 2; post-stroke depression
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