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Comment 109 An Assessment of Some Recommendations Made Concerning the OECD Health Effects Test Guidelines Angela Auletta Auletta Consulting, 133 Calhoun Street, Edgewater MD 21037, USA E-mail: AAul969490@aol.com Shortly after its publication, I had an opportunity initiated. Moreover, I suspect that any revised to review your article on the OECD Health Test guideline would retain a requirement for a second Guidelines, and I want to say that I could not agree species (both the rat and the mouse for carcino- more with many of your concerns about the OECD genicity bioassay, and the dog or a non-human pri- Heath Effects Test Guidelines (TGs) and your rec- mate for chronic toxicity testing, respectively). This ommendations for their improvement. is because there is much resistance to change on the However, as I am sure you appreciate, some of your part of some regulators. In addition, there has been ideas, although they make good sense, will never be regular discussion about the need to revise TG 417 implemented for a variety of reasons, some of them (toxicokinetics) for some time, but no such revision political, rather than scientific. A good example of has yet been undertaken, despite the fact that many such
Alternatives to Laboratory Animals – SAGE
Published: Feb 1, 2006
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