Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

An Approach to Pain in Research Animals

An Approach to Pain in Research Animals Pain can either signal the threat of tissue-damage (nociception) or can result from tissue damage itself. The physiology and “pathology” of pain, in the second instance, suggest that it can be diagnosed (not “measured”, “assessed”, etc.) on the basis of its association, but not equality, with tissue damage and by its coincidence with changes in behaviour. Pain will be present as part of a syndrome and cannot occur without cause or association. Pain may occur in experiments:a) coincidentally and unrelated to any experimental procedure,b) accidentally, when a procedure goes amiss, andc) as part of the experimental design.Where pain is intrinsic to the aims of an experiment (for example in the testing of analgesics), “escape routes” and “limits” must be formulated for the benefit of experimental subjects. In addition, the empirical value of the experiment must be assessed.There is insufficient information on the use and efficacy of analgesic drugs in animals. These drugs, however, are neither the only nor the most effective means of alleviating physical pain in animals. Other forms of treatment are considered. All depend on sound diagnosis and prognosis. Decisive action against the cause of pain is necessary. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alternatives to Laboratory Animals SAGE

An Approach to Pain in Research Animals

Alternatives to Laboratory Animals , Volume 16 (2): 10 – Dec 1, 1988

Loading next page...
 
/lp/sage/an-approach-to-pain-in-research-animals-RD0BCx8vW6

References (10)

Publisher
SAGE
Copyright
© 1988 Fund for the Replacement of Animals in Medical Experiments
ISSN
0261-1929
eISSN
2632-3559
DOI
10.1177/026119298801600205
Publisher site
See Article on Publisher Site

Abstract

Pain can either signal the threat of tissue-damage (nociception) or can result from tissue damage itself. The physiology and “pathology” of pain, in the second instance, suggest that it can be diagnosed (not “measured”, “assessed”, etc.) on the basis of its association, but not equality, with tissue damage and by its coincidence with changes in behaviour. Pain will be present as part of a syndrome and cannot occur without cause or association. Pain may occur in experiments:a) coincidentally and unrelated to any experimental procedure,b) accidentally, when a procedure goes amiss, andc) as part of the experimental design.Where pain is intrinsic to the aims of an experiment (for example in the testing of analgesics), “escape routes” and “limits” must be formulated for the benefit of experimental subjects. In addition, the empirical value of the experiment must be assessed.There is insufficient information on the use and efficacy of analgesic drugs in animals. These drugs, however, are neither the only nor the most effective means of alleviating physical pain in animals. Other forms of treatment are considered. All depend on sound diagnosis and prognosis. Decisive action against the cause of pain is necessary.

Journal

Alternatives to Laboratory AnimalsSAGE

Published: Dec 1, 1988

There are no references for this article.