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Acupuncture - Electro Stimulation

Acupuncture - Electro Stimulation Transcripts of Talk given at AGM of BMAS meeting -1.0. Capel Using the antipyrine clearance hepatic decrease sleeping time provided it was function test it was observed that NET administered immediately after the LRR, ES (Neuro Electric Therapy) electrostimulation for the second 30 minutes after narcosis (ES) increased liver function even in some produces no significant effect. Intermittent patients whose clearance was already rapid ES (5 minutes on and 5'minutes off) for the as a result of chronic barbiturate abuse. It duration of narcosis will also decrease was noted that ES decreased barbiturate sleeping time. induced loss of righting reflex {LRR} in , ES decreases the duration of LRR in other acutely dosed rats. There was no difference rodents but the optimal frequency to reduce between AC or DCcurrent in producing this hexobarbital narcosis differed in each response but square wave was far more species. Some strains of mice exhibited a efficacious than sine. Using this LRR model greater decrease in sleeping time following itwas found that 1vwasthe optimal voltage ESthan others, the most sensitive being the intensity, and 0.22 m sec the optimal pulse C57Bl. width to produce this response. Examination of the microsomes prepared The most important determinant of LRR from the livers of rats which had received was the frequency of the ESapplied. Thus in ES indicated that the decrease in LRR was the case of barbiturate induced narcosis 2 not mediated via increased hepatic enzyme frequencies (10 and 500 Hz) were efficacious induction. in decreasing sleeping time. A frequency of Prior administration of the specific opiate 30 Hz was efficacious for ketarnine, and 500 antagonist naloxone diminished the effect Hz in the case of ethanol. It was concluded of slow frequency ES but enhanced the that differing frequencies are necessary to effect of fast frequency ES on barbiturate reduce LRR caused by the acute anaesthesia. Blood corticosterone levels are administration of differing drugs. significantly decreased following slow, but In the case of barbiturates slow or fast increased following fast frequency ES. frequency ES applied cranially (via the ears) It is concluded that this action of slow and will decrease sleeping time but applied fast frequency ES are produced by different peripherally (via the fore-paws) only fast mechanisms and that the former is frequency ESwill produce this response. associated with increased S endorphin ES for only 30 minutes is sufficient to activity. The Neuropharmacology of Acupuncture Paul Price, MB, Bsc, MRCP. The report that transfer of CSFfrom These results concur with the naloxone rabbits having acupuncture produced studies since the effects of 8-endorphin are analgesia in recipient rabbits confirms that sensitive to naloxone blockade but those of acupunture has a neurohumeral basis. The met-enhaphalln are relatively insensitive to opioid peptides B-endorphin and met­ naloxone. enhephalin, as well as 5-HT(Serotonin) Release of 5-HTinto the CSF has been have so far been shown to be neurohumeral demonstrated during acupuncture mediators of acupuncture. analgesia. In addition, drugs which increase The opiate antoqanist naloxone when cerebral5-HT levels enhance acupuncture given in conventional dosesto animals or analgesia, and 5-HT blocking drugs man, reduces the analgesia produced by decrease acupuncture analgesia. In mice, manual acupuncture and low frequency high frequency electroacupuncture electroacupuncture. Nalaxone has no effect analgesia is reduced by lowering cerebral on high frequency electroacupuncture 5-HT levels with parachlorphenylalonine analgesia. Acupuncture causesthe central whereas low freq uency electroacupuncture release of opioid peptides which can be analgesia is unaffected; the opposite effect measured in the CSF. The most opiold of naloxone. assays,the structural identity of these Low frequency electroacupuncture may peptides is uncertain. Clement-Jones and releose B-endorphin in the periaqueductal her colleagues reported that low frequency gray thus activiating a descending pain electroacupuncture for the relief of chronic inhibitory pathway. High frequency pain caused an elevation of CSF B­ electroacupuncture however may activate a descending serotoninergic pathway arising endorphin levels but had no effect on CSF in the nucleus raphe magnus in the medulla met-enhephalin levels. Conversely high frequency electroacupuncture for the relief which, via short enhephalinergic interneurones in the spinal dorsal horns, of heroinwithdrawal symptoms had no effect but produced an on CSFB-endorphin levels inhibits the firing of nociceptive dorsal horn neurones. increase in CSF met-enhephalin levels. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acupuncture in Medicine SAGE

Acupuncture - Electro Stimulation

Acupuncture in Medicine , Volume 1 (1): 1 – Jan 1, 1983
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Publisher
SAGE
Copyright
© 1983 British Medical Acupuncutre Society
ISSN
0964-5284
eISSN
1759-9873
DOI
10.1136/aim.1.1.9
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Abstract

Transcripts of Talk given at AGM of BMAS meeting -1.0. Capel Using the antipyrine clearance hepatic decrease sleeping time provided it was function test it was observed that NET administered immediately after the LRR, ES (Neuro Electric Therapy) electrostimulation for the second 30 minutes after narcosis (ES) increased liver function even in some produces no significant effect. Intermittent patients whose clearance was already rapid ES (5 minutes on and 5'minutes off) for the as a result of chronic barbiturate abuse. It duration of narcosis will also decrease was noted that ES decreased barbiturate sleeping time. induced loss of righting reflex {LRR} in , ES decreases the duration of LRR in other acutely dosed rats. There was no difference rodents but the optimal frequency to reduce between AC or DCcurrent in producing this hexobarbital narcosis differed in each response but square wave was far more species. Some strains of mice exhibited a efficacious than sine. Using this LRR model greater decrease in sleeping time following itwas found that 1vwasthe optimal voltage ESthan others, the most sensitive being the intensity, and 0.22 m sec the optimal pulse C57Bl. width to produce this response. Examination of the microsomes prepared The most important determinant of LRR from the livers of rats which had received was the frequency of the ESapplied. Thus in ES indicated that the decrease in LRR was the case of barbiturate induced narcosis 2 not mediated via increased hepatic enzyme frequencies (10 and 500 Hz) were efficacious induction. in decreasing sleeping time. A frequency of Prior administration of the specific opiate 30 Hz was efficacious for ketarnine, and 500 antagonist naloxone diminished the effect Hz in the case of ethanol. It was concluded of slow frequency ES but enhanced the that differing frequencies are necessary to effect of fast frequency ES on barbiturate reduce LRR caused by the acute anaesthesia. Blood corticosterone levels are administration of differing drugs. significantly decreased following slow, but In the case of barbiturates slow or fast increased following fast frequency ES. frequency ES applied cranially (via the ears) It is concluded that this action of slow and will decrease sleeping time but applied fast frequency ES are produced by different peripherally (via the fore-paws) only fast mechanisms and that the former is frequency ESwill produce this response. associated with increased S endorphin ES for only 30 minutes is sufficient to activity. The Neuropharmacology of Acupuncture Paul Price, MB, Bsc, MRCP. The report that transfer of CSFfrom These results concur with the naloxone rabbits having acupuncture produced studies since the effects of 8-endorphin are analgesia in recipient rabbits confirms that sensitive to naloxone blockade but those of acupunture has a neurohumeral basis. The met-enhaphalln are relatively insensitive to opioid peptides B-endorphin and met­ naloxone. enhephalin, as well as 5-HT(Serotonin) Release of 5-HTinto the CSF has been have so far been shown to be neurohumeral demonstrated during acupuncture mediators of acupuncture. analgesia. In addition, drugs which increase The opiate antoqanist naloxone when cerebral5-HT levels enhance acupuncture given in conventional dosesto animals or analgesia, and 5-HT blocking drugs man, reduces the analgesia produced by decrease acupuncture analgesia. In mice, manual acupuncture and low frequency high frequency electroacupuncture electroacupuncture. Nalaxone has no effect analgesia is reduced by lowering cerebral on high frequency electroacupuncture 5-HT levels with parachlorphenylalonine analgesia. Acupuncture causesthe central whereas low freq uency electroacupuncture release of opioid peptides which can be analgesia is unaffected; the opposite effect measured in the CSF. The most opiold of naloxone. assays,the structural identity of these Low frequency electroacupuncture may peptides is uncertain. Clement-Jones and releose B-endorphin in the periaqueductal her colleagues reported that low frequency gray thus activiating a descending pain electroacupuncture for the relief of chronic inhibitory pathway. High frequency pain caused an elevation of CSF B­ electroacupuncture however may activate a descending serotoninergic pathway arising endorphin levels but had no effect on CSF in the nucleus raphe magnus in the medulla met-enhephalin levels. Conversely high frequency electroacupuncture for the relief which, via short enhephalinergic interneurones in the spinal dorsal horns, of heroinwithdrawal symptoms had no effect but produced an on CSFB-endorphin levels inhibits the firing of nociceptive dorsal horn neurones. increase in CSF met-enhephalin levels.

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Acupuncture in Medicine – SAGE

Published: Jan 1, 1983

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