Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Accuracy of iodine quantification using dual-energy computed tomography with focus on low concentrations

Accuracy of iodine quantification using dual-energy computed tomography with focus on low... BackgroundIodine quantification using dual-energy computed tomography (DECT) is helpful in characterizing, and follow-up after treatment of tumors. Some malignant masses, for instance papillary renal cell carcinomas (p-RCC), are hard to differentiate from benign lesions because of very low contrast enhancement. In these cases, iodine concentrations might be very low, and it is therefore important that iodine quantification is reliable even at low concentrations if this technique is used.PurposeTo examine the accuracy of iodine quantification and to determine whether it is also accurate for low iodine concentrations.Material and MethodsTwenty-six syringes with different iodine concentrations (0–30 mg I/mL) were scanned in a phantom model using a DECT scanner with two different kilovoltage and image reconstruction settings. Iodine concentrations were measured and compared to known concentration. Absolute and relative errors were calculated.ResultsFor concentrations of 1 mg I/mL or higher, there was an excellent correlation between true and measured iodine concentrations for all settings (R = 0.999–1.000; P < 0.001). For concentrations <1.0 mg I/mL, the relative error was greater. Absolute and relative errors were smaller using tube voltages of 80/Sn140 kV than 100/Sn140 kV (P < 0.01). Reconstructions using a 3.0-mm slice thickness had less variance between repeated acquisitions versus 0.6 mm (P < 0.001).ConclusionIodine quantification using DECT was in general very accurate, but for concentrations < 1.0 mg I/mL the technique was less reliable. Using a tube voltage with larger spectral separation was more accurate and the result was more reproducible using thicker image reconstructions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Radiologica SAGE

Accuracy of iodine quantification using dual-energy computed tomography with focus on low concentrations

Loading next page...
 
/lp/sage/accuracy-of-iodine-quantification-using-dual-energy-computed-7cEfl3XVCy

References (15)

Publisher
SAGE
Copyright
© The Foundation Acta Radiologica 2021
ISSN
0284-1851
eISSN
1600-0455
DOI
10.1177/02841851211009462
Publisher site
See Article on Publisher Site

Abstract

BackgroundIodine quantification using dual-energy computed tomography (DECT) is helpful in characterizing, and follow-up after treatment of tumors. Some malignant masses, for instance papillary renal cell carcinomas (p-RCC), are hard to differentiate from benign lesions because of very low contrast enhancement. In these cases, iodine concentrations might be very low, and it is therefore important that iodine quantification is reliable even at low concentrations if this technique is used.PurposeTo examine the accuracy of iodine quantification and to determine whether it is also accurate for low iodine concentrations.Material and MethodsTwenty-six syringes with different iodine concentrations (0–30 mg I/mL) were scanned in a phantom model using a DECT scanner with two different kilovoltage and image reconstruction settings. Iodine concentrations were measured and compared to known concentration. Absolute and relative errors were calculated.ResultsFor concentrations of 1 mg I/mL or higher, there was an excellent correlation between true and measured iodine concentrations for all settings (R = 0.999–1.000; P < 0.001). For concentrations <1.0 mg I/mL, the relative error was greater. Absolute and relative errors were smaller using tube voltages of 80/Sn140 kV than 100/Sn140 kV (P < 0.01). Reconstructions using a 3.0-mm slice thickness had less variance between repeated acquisitions versus 0.6 mm (P < 0.001).ConclusionIodine quantification using DECT was in general very accurate, but for concentrations < 1.0 mg I/mL the technique was less reliable. Using a tube voltage with larger spectral separation was more accurate and the result was more reproducible using thicker image reconstructions.

Journal

Acta RadiologicaSAGE

Published: May 1, 2022

Keywords: Iodine quantification; dual-energy computed tomography; phantom study; tumor enhancement

There are no references for this article.